22 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	Dna2.S	Uncharacterized protein. (1053 aa)
	mdc1	Uncharacterized protein. (2103 aa)
	Exo1.S	Uncharacterized protein. (734 aa)
	top1.1	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (821 aa)
	topbp1	Uncharacterized protein. (1573 aa)
	Rbbp8.L	Uncharacterized protein. (856 aa)
	Prkdc.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (4146 aa)
	top1.2	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (770 aa)
	Rad26	Uncharacterized protein. (798 aa)
	atrip	Uncharacterized protein. (801 aa)
	rad50	Zinc-hook domain-containing protein. (1311 aa)
	rad50-2	Zinc-hook domain-containing protein. (1312 aa)
	neil3	Uncharacterized protein. (616 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	rbbp8	Uncharacterized protein. (846 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	Rad17.L	Uncharacterized protein. (674 aa)
	Clspn.S	Claspin. (1286 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Chek2.L	Clspn.S	A0A1L8I0A0	F8WKR8	Uncharacterized protein.	Claspin.	0.891
Chek2.L	Dna2.S	A0A1L8I0A0	A0A1L8FF41	Uncharacterized protein.	Uncharacterized protein.	0.910
Chek2.L	Exo1.S	A0A1L8I0A0	A0A1L8F3G5	Uncharacterized protein.	Uncharacterized protein.	0.974
Chek2.L	Hus1	A0A1L8I0A0	Q8JHD8	Uncharacterized protein.	Checkpoint protein; Belongs to the HUS1 family.	0.948
Chek2.L	Prkdc.L	A0A1L8I0A0	A0A1L8FYZ4	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.876
Chek2.L	Rad17.L	A0A1L8I0A0	A0A1L8I1Y0	Uncharacterized protein.	Uncharacterized protein.	0.950
Chek2.L	Rad26	A0A1L8I0A0	A0A1L8GP12	Uncharacterized protein.	Uncharacterized protein.	0.895
Chek2.L	Rbbp8.L	A0A1L8I0A0	A0A1L8FYP2	Uncharacterized protein.	Uncharacterized protein.	0.799
Chek2.L	atrip	A0A1L8I0A0	A0A1L8GH95	Uncharacterized protein.	Uncharacterized protein.	0.895
Chek2.L	chek1	A0A1L8I0A0	A0A1L8FFS1	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.992
Chek2.L	chek1-2	A0A1L8I0A0	A0A1L8FL95	Uncharacterized protein.	Protein kinase domain-containing protein.	0.992
Chek2.L	mdc1	A0A1L8I0A0	A0A1L8F8K7	Uncharacterized protein.	Uncharacterized protein.	0.945
Chek2.L	pcna	A0A1L8I0A0	Q9I893	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.491
Chek2.L	rad50	A0A1L8I0A0	A0A1L8GVF0	Uncharacterized protein.	Zinc-hook domain-containing protein.	0.668
Chek2.L	rad50-2	A0A1L8I0A0	A0A1L8GXM0	Uncharacterized protein.	Zinc-hook domain-containing protein.	0.668
Chek2.L	rad9a	A0A1L8I0A0	Q7ZZU5	Uncharacterized protein.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.953
Chek2.L	rbbp8	A0A1L8I0A0	A0A1L8FSU5	Uncharacterized protein.	Uncharacterized protein.	0.799
Chek2.L	top1.1	A0A1L8I0A0	A0A1L8EU24	Uncharacterized protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.510
Chek2.L	top1.2	A0A1L8I0A0	A0A1L8GF75	Uncharacterized protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.510
Chek2.L	topbp1	A0A1L8I0A0	A0A1L8FWJ6	Uncharacterized protein.	Uncharacterized protein.	0.932