95 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8ESF5	Angiotensin-converting enzyme; Belongs to the peptidase M2 family. (939 aa)
	prickle1	Uncharacterized protein. (835 aa)
	pax8	Paired domain-containing protein. (467 aa)
	prickle2-2	Uncharacterized protein. (833 aa)
	Rho.L	Rhodopsin. (459 aa)
	nphs2	PHB domain-containing protein. (375 aa)
	Prkacb.S	Uncharacterized protein; Belongs to the protein kinase superfamily. (338 aa)
	nfatc3	RHD domain-containing protein. (885 aa)
	prickle2	Uncharacterized protein. (833 aa)
	Nphs2.S	PHB domain-containing protein. (370 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (396 aa)
	Ahi1.L	Uncharacterized protein. (1124 aa)
	Agt.L	SERPIN domain-containing protein; Belongs to the serpin family. (466 aa)
	six2-2	Homeobox domain-containing protein. (289 aa)
	fzd3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
	agtr1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	Agt.S	SERPIN domain-containing protein; Belongs to the serpin family. (466 aa)
	six2	Homeobox domain-containing protein. (289 aa)
	sfrp4	Uncharacterized protein. (353 aa)
	Fzd8.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	Aqp1.L	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (274 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Scrib.S	Uncharacterized protein. (1826 aa)
	Myc.S	Myc_N domain-containing protein. (176 aa)
	Aqp1.S	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (274 aa)
	axin2	Uncharacterized protein. (707 aa)
	wnt4-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	Arhgef19.L	Uncharacterized protein. (570 aa)
	Bax.L	Uncharacterized protein. (221 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	emx2	Homeobox domain-containing protein. (243 aa)
	vangl2-2	Vang-like protein. (521 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	vangl2	Vang-like protein. (521 aa)
	prickle3-b	Prickle planar cell polarity protein 3-B; Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules. Proteins of the core module include the proteins Frizzled (Fz), Disheveled (Dsh), Van Gogh (Vang), Prickle (Pk), Flamingo (Fmi, Celsr) and Diego (Dgo). The core module proteins develop subcellular asymmetry, accumulating in two groups on opposite sides of epithelial cells. D [...] (536 aa)
	daam1	Uncharacterized protein. (1077 aa)
	fzd7	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	A0A1L8EUY4	Uncharacterized protein. (818 aa)
	nfatc2	RHD domain-containing protein. (896 aa)
	hoxb7	Homeobox domain-containing protein. (220 aa)
	A0A1L8ELB6	Uncharacterized protein. (261 aa)
	Nfatc2.S	RHD domain-containing protein. (884 aa)
	A0A1L8ENI4	Uncharacterized protein. (815 aa)
	wnt10a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	Fn1.S	Uncharacterized protein. (2480 aa)
	fzd5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	wnt9b.2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	bmp4-2	Bone morphogenetic protein 4. (400 aa)
	lef1-2	Lymphoid enhancer factor XLEF-1. (372 aa)
	prkaca	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	ccnd1	Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
	ror2-2	Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	atp6ap2-2	Atp6ap2-prov protein. (348 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	emx2-2	MGC81839 protein. (245 aa)
	axin2-2	MGC81576 protein. (707 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	rac1	MGC114731 protein. (192 aa)
	atp6ap2	MGC114665 protein. (348 aa)
	hoxb7-2	Hoxb7 protein. (221 aa)
	nck1-2	Cytoplasmic protein. (377 aa)
	nck1	Cytoplasmic protein. (377 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	wnt7b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	invs-a	Inversin. (1007 aa)
	xfz8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	wnt10a-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	fz3	Fz3 protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
	nf-at	Nuclear factor of activated T-cell. (884 aa)
	bmp4	Bone morphogenetic protein 4. (401 aa)
	wnt6-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	Gdnf.L	TGF_BETA_2 domain-containing protein. (332 aa)
	Gdnf.S	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (227 aa)
	foxd1	Fork-head domain-containing protein. (333 aa)
	ror2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	lef1	HMG box domain-containing protein. (372 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	kl-2	Uncharacterized protein. (984 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	nck2-2	Cytoplasmic protein. (381 aa)
	A0A1L8HCX9	Angiotensin-converting enzyme. (876 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	kl	Uncharacterized protein. (983 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	nck2	Cytoplasmic protein. (381 aa)
	Ren.S	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (366 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	Ace2.S	Angiotensin-converting enzyme. (730 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	Serpine1.L	SERPIN domain-containing protein; Belongs to the serpin family. (403 aa)
	pax8-2	Paired domain-containing protein. (465 aa)
	Prickle1.L	Uncharacterized protein. (832 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ELB6	A0A1L8H5Q6	A0A1L8ELB6	A0A1L8H5Q6	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.460
A0A1L8ELB6	Tp53.L	A0A1L8ELB6	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.511
A0A1L8ELB6	bmp4	A0A1L8ELB6	B7ZPR8	Uncharacterized protein.	Bone morphogenetic protein 4.	0.429
A0A1L8ELB6	bmp4-2	A0A1L8ELB6	Q91703	Uncharacterized protein.	Bone morphogenetic protein 4.	0.429
A0A1L8ELB6	ctnnb1	A0A1L8ELB6	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.509
A0A1L8ELB6	myc	A0A1L8ELB6	Q6NRN4	Uncharacterized protein.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.449
A0A1L8ENI4	A0A1L8H5Q6	A0A1L8ENI4	A0A1L8H5Q6	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.998
A0A1L8ENI4	Fzd4.S	A0A1L8ENI4	A0A1L8HB90	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.665
A0A1L8ENI4	Fzd8.L	A0A1L8ENI4	A0A1L8FVD0	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.635
A0A1L8ENI4	Myc.S	A0A1L8ENI4	A0A1L8FTW7	Uncharacterized protein.	Myc_N domain-containing protein.	0.692
A0A1L8ENI4	Tp53.L	A0A1L8ENI4	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.591
A0A1L8ENI4	Wnt1.L	A0A1L8ENI4	A0A1L8HHR8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.872
A0A1L8ENI4	bmp4	A0A1L8ENI4	B7ZPR8	Uncharacterized protein.	Bone morphogenetic protein 4.	0.569
A0A1L8ENI4	bmp4-2	A0A1L8ENI4	Q91703	Uncharacterized protein.	Bone morphogenetic protein 4.	0.561
A0A1L8ENI4	ccnd1	A0A1L8ENI4	Q8AVQ4	Uncharacterized protein.	Ccnd1-prov protein; Belongs to the cyclin family.	0.853
A0A1L8ENI4	ctnnb1	A0A1L8ENI4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.998
A0A1L8ENI4	daam1	A0A1L8ENI4	A0A1L8EZW6	Uncharacterized protein.	Uncharacterized protein.	0.420
A0A1L8ENI4	dkk1	A0A1L8ENI4	A0A1L8FIS6	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.899
A0A1L8ENI4	dkk1-2	A0A1L8ENI4	O57464	Uncharacterized protein.	Dickkopf homolog 1.	0.900
A0A1L8ENI4	fz3	A0A1L8ENI4	B7ZQS8	Uncharacterized protein.	Fz3 protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.517