68 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	shc1	Uncharacterized protein. (605 aa)
	stau1	Uncharacterized protein. (707 aa)
	ddx18	RNA helicase. (641 aa)
	cxcr4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	Map2.S	Microtubule-associated protein. (1811 aa)
	Ddx18.L	RNA helicase. (638 aa)
	Cxcr4.L	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	Map2.L	Microtubule-associated protein. (1769 aa)
	fmr1	Uncharacterized protein. (564 aa)
	Ddx31.L	RNA helicase. (462 aa)
	Gnrhr.L	G_PROTEIN_RECEP_F1_2 domain-containing protein. (418 aa)
	Shc1.L	Uncharacterized protein. (601 aa)
	Cxcl12.S	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
	rpl22	Uncharacterized protein. (128 aa)
	A0A1L8FI55	G_PROTEIN_RECEP_F1_2 domain-containing protein. (385 aa)
	cxcl12	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (89 aa)
	A0A1L8FMG2	Uncharacterized protein. (446 aa)
	stau2	Uncharacterized protein. (703 aa)
	mbp	Uncharacterized protein. (308 aa)
	stmn2	Stathmin; Belongs to the stathmin family. (178 aa)
	arc	Arc_C domain-containing protein. (383 aa)
	fshr	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (692 aa)
	slc35d3	Uncharacterized protein. (420 aa)
	fxr1	Uncharacterized protein. (675 aa)
	gnb4	WD_REPEATS_REGION domain-containing protein. (340 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	FSHR	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (701 aa)
	fyn	Tyrosine-protein kinase. (537 aa)
	Irs1.S	Uncharacterized protein. (1227 aa)
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	Rgs2.L	RGS domain-containing protein. (215 aa)
	Ebf1	COE1_DBD domain-containing protein. (312 aa)
	Mex3b.S	RING-type domain-containing protein. (507 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
	dusp1	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (369 aa)
	dusp1-2	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (369 aa)
	egr1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (497 aa)
	mex3b	RING-type domain-containing protein. (511 aa)
	gnrh1	Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (89 aa)
	Rps6kb1.S	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
	Nr4a1.S	Uncharacterized protein. (653 aa)
	A0A1L8HAU8	RNA helicase. (784 aa)
	rps6kb1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (521 aa)
	nr4a1	Uncharacterized protein. (584 aa)
	Kit.S	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (963 aa)
	Eif4e1b.S	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (280 aa)
	Upf1.S	Uncharacterized protein. (1098 aa)
	ddx55	RNA helicase. (594 aa)
	lox	Uncharacterized protein. (422 aa)
	map1b	Uncharacterized protein. (2247 aa)
	Kit.L	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
	Lox.L	Uncharacterized protein. (457 aa)
	map1b-2	Uncharacterized protein. (2255 aa)
	Fus.L	Uncharacterized protein. (511 aa)
	pten	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	fxr1-2	LOC398050 protein. (649 aa)
	fos	BZIP domain-containing protein. (369 aa)
	mbp-2	Golli protein J37.1. (306 aa)
	fmr1-A	Fragile X mental retardation 1. (564 aa)
	fyn-2	Tyrosine-protein kinase. (537 aa)
	vegfa	Vascular endothelial growth factor 196; Belongs to the PDGF/VEGF growth factor family. (194 aa)
	edn1	LOC100158354 protein. (221 aa)
	src	Tyrosine-protein kinase. (532 aa)
	rgs2	RGS domain-containing protein. (216 aa)
	eif4e	MGC85107 protein; Belongs to the eukaryotic initiation factor 4E family. (213 aa)
	fos-2	MGC80305 protein. (368 aa)
	stmn2-2	Stathmin; Belongs to the stathmin family. (178 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FI55	gnb4	A0A1L8FI55	A0A1L8G482	G_PROTEIN_RECEP_F1_2 domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.690
A0A1L8FMG2	Eif4e1b.S	A0A1L8FMG2	A0A1L8HM93	Uncharacterized protein.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.623
A0A1L8FMG2	arc	A0A1L8FMG2	A0A1L8G0A8	Uncharacterized protein.	Arc_C domain-containing protein.	0.460
A0A1L8FMG2	eif4e	A0A1L8FMG2	Q5HZ86	Uncharacterized protein.	MGC85107 protein; Belongs to the eukaryotic initiation factor 4E family.	0.629
A0A1L8FMG2	fxr1	A0A1L8FMG2	A0A1L8G3Y8	Uncharacterized protein.	Uncharacterized protein.	0.614
A0A1L8FMG2	fxr1-2	A0A1L8FMG2	A3KMH8	Uncharacterized protein.	LOC398050 protein.	0.615
A0A1L8FMG2	map1b	A0A1L8FMG2	A0A1L8HRF3	Uncharacterized protein.	Uncharacterized protein.	0.690
A0A1L8FMG2	map1b-2	A0A1L8FMG2	A0A1L8I219	Uncharacterized protein.	Uncharacterized protein.	0.690
A0A1L8FMG2	stau1	A0A1L8FMG2	A0A1L8ELE8	Uncharacterized protein.	Uncharacterized protein.	0.870
A0A1L8FMG2	stau2	A0A1L8FMG2	A0A1L8FT79	Uncharacterized protein.	Uncharacterized protein.	0.616
A0A1L8HAU8	Ddx18.L	A0A1L8HAU8	A0A1L8EV49	RNA helicase.	RNA helicase.	0.991
A0A1L8HAU8	Ddx31.L	A0A1L8HAU8	A0A1L8F6D3	RNA helicase.	RNA helicase.	0.917
A0A1L8HAU8	Eif4e1b.S	A0A1L8HAU8	A0A1L8HM93	RNA helicase.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.947
A0A1L8HAU8	Fus.L	A0A1L8HAU8	A0A310U9Q7	RNA helicase.	Uncharacterized protein.	0.412
A0A1L8HAU8	Upf1.S	A0A1L8HAU8	A0A1L8HN47	RNA helicase.	Uncharacterized protein.	0.675
A0A1L8HAU8	ddx18	A0A1L8HAU8	A0A1L8ENF7	RNA helicase.	RNA helicase.	0.991
A0A1L8HAU8	ddx55	A0A1L8HAU8	A0A1L8HQL1	RNA helicase.	RNA helicase.	0.866
A0A1L8HAU8	eif4e	A0A1L8HAU8	Q5HZ86	RNA helicase.	MGC85107 protein; Belongs to the eukaryotic initiation factor 4E family.	0.946
A0A1L8HAU8	fxr1	A0A1L8HAU8	A0A1L8G3Y8	RNA helicase.	Uncharacterized protein.	0.418
A0A1L8HAU8	fxr1-2	A0A1L8HAU8	A3KMH8	RNA helicase.	LOC398050 protein.	0.417