93 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Bmi1.L	RING-type domain-containing protein. (323 aa)
	Sox2.S	HMG box domain-containing protein. (194 aa)
	Gast.S	Gastrin domain-containing protein. (103 aa)
	A0A1L8ENI4	Uncharacterized protein. (815 aa)
	fzd5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	Gast.L	Gastrin domain-containing protein. (103 aa)
	Sdc4.L	Syndecan domain-containing protein. (205 aa)
	A0A1L8EUY4	Uncharacterized protein. (818 aa)
	fzd7	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
	chga	Uncharacterized protein. (438 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	prickle3-b	Prickle planar cell polarity protein 3-B; Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules. Proteins of the core module include the proteins Frizzled (Fz), Disheveled (Dsh), Van Gogh (Vang), Prickle (Pk), Flamingo (Fmi, Celsr) and Diego (Dgo). The core module proteins develop subcellular asymmetry, accumulating in two groups on opposite sides of epithelial cells. D [...] (536 aa)
	notch1	Uncharacterized protein. (2521 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	chga-2	Uncharacterized protein. (421 aa)
	ascl2	BHLH domain-containing protein. (161 aa)
	kras	Uncharacterized protein. (186 aa)
	Tcf7l2.L	HMG box domain-containing protein. (482 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	axin2	Uncharacterized protein. (707 aa)
	Bmi1.S	RING-type domain-containing protein. (367 aa)
	egfr	Receptor protein-tyrosine kinase. (1208 aa)
	Fzd6.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	egfr-2	Receptor protein-tyrosine kinase. (1210 aa)
	fzd6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (724 aa)
	calm1	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	rspo3	Uncharacterized protein. (253 aa)
	Sst.2	Somatostatin domain-containing protein. (157 aa)
	ryk	Uncharacterized protein. (596 aa)
	wls	Uncharacterized protein. (541 aa)
	Mier1.S	Uncharacterized protein. (479 aa)
	prickle2	Uncharacterized protein. (833 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	Wls.L	Uncharacterized protein. (541 aa)
	prickle2-2	Uncharacterized protein. (833 aa)
	calml4	Uncharacterized protein. (153 aa)
	prickle1	Uncharacterized protein. (835 aa)
	lgr5	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	Lgr5.L	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	Prickle1.L	Uncharacterized protein. (832 aa)
	calml4-2	Uncharacterized protein. (152 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	bcl9	BCL9 domain-containing protein. (1473 aa)
	Atp1a1.S	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1106 aa)
	rnf43	RING-type domain-containing protein. (664 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	cckbr	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (453 aa)
	atp1a1	Sodium/potassium-transporting ATPase subunit alpha. (1025 aa)
	Bcl9.L	BCL9 domain-containing protein. (1387 aa)
	Runx1.L	Runt-related transcription factor. (462 aa)
	cdkn1a	Uncharacterized protein. (261 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	cckbr-2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (453 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Kit.S	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (963 aa)
	dclk2	Uncharacterized protein. (734 aa)
	dot1l	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1396 aa)
	ror2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	fzd10	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
	Znrf3.S	RING-type domain-containing protein. (848 aa)
	apc	Uncharacterized protein. (2827 aa)
	Kit.L	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
	Egf.L	Uncharacterized protein. (1031 aa)
	dot1l-2	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1396 aa)
	hopx	Homeobox domain-containing protein. (80 aa)
	znrf3	RING-type domain-containing protein. (854 aa)
	apc-2	Uncharacterized protein. (2834 aa)
	rspo2	R-spondin 2. (243 aa)
	Xwnt-8b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (428 aa)
	fzd10a	Frizzled 10A; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
	efnb1	Ephrin-B1 (EPH family ligand); Belongs to the ephrin family. (329 aa)
	grem1	Gremlin. (182 aa)
	ghrl	Ghrelin. (118 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	rac1	MGC114731 protein. (192 aa)
	krasl	Uncharacterized protein. (187 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	axin2-2	MGC81576 protein. (707 aa)
	kras-2	Uncharacterized protein. (187 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	rhoa	MGC64296 protein. (193 aa)
	sst	Preprosomatostatin 1a. (115 aa)
	ror2-2	Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	ccnd1	Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
	creb1	Creb1-prov protein. (324 aa)
	hras	Small G-protein H-Ras. (189 aa)
	ascl2-2	Achaete-scute homolog 3b. (191 aa)
	kras-3	LOC397771 protein. (186 aa)
	tert	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1191 aa)
	rac3	RAC1 protein. (192 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENI4	Bcl9.L	A0A1L8ENI4	A0A1L8HC43	Uncharacterized protein.	BCL9 domain-containing protein.	0.561
A0A1L8ENI4	Fzd4.S	A0A1L8ENI4	A0A1L8HB90	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.665
A0A1L8ENI4	Fzd6.S	A0A1L8ENI4	A0A1L8FTP5	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.566
A0A1L8ENI4	Lgr5.L	A0A1L8ENI4	A0A1L8GYN0	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.817
A0A1L8ENI4	Lrp5.L	A0A1L8ENI4	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.928
A0A1L8ENI4	Notch1.S	A0A1L8ENI4	A0A1L8F124	Uncharacterized protein.	Uncharacterized protein.	0.558
A0A1L8ENI4	Sox2.S	A0A1L8ENI4	A0A1L8EK54	Uncharacterized protein.	HMG box domain-containing protein.	0.445
A0A1L8ENI4	Tcf7l2.L	A0A1L8ENI4	A0A1L8FI38	Uncharacterized protein.	HMG box domain-containing protein.	0.775
A0A1L8ENI4	Tp53.L	A0A1L8ENI4	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.591
A0A1L8ENI4	Wls.L	A0A1L8ENI4	A0A1L8GLU8	Uncharacterized protein.	Uncharacterized protein.	0.674
A0A1L8ENI4	Wnt1.L	A0A1L8ENI4	A0A1L8HHR8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.872
A0A1L8ENI4	Xwnt-8b	A0A1L8ENI4	B7ZQM6	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.719
A0A1L8ENI4	Znrf3.S	A0A1L8ENI4	A0A1L8HQY2	Uncharacterized protein.	RING-type domain-containing protein.	0.623
A0A1L8ENI4	apc	A0A1L8ENI4	A0A1L8HR21	Uncharacterized protein.	Uncharacterized protein.	0.959
A0A1L8ENI4	apc-2	A0A1L8ENI4	A0A1L8I1P0	Uncharacterized protein.	Uncharacterized protein.	0.959
A0A1L8ENI4	ascl2	A0A1L8ENI4	A0A1L8FGZ8	Uncharacterized protein.	BHLH domain-containing protein.	0.508
A0A1L8ENI4	ascl2-2	A0A1L8ENI4	Q91558	Uncharacterized protein.	Achaete-scute homolog 3b.	0.508
A0A1L8ENI4	bcl9	A0A1L8ENI4	A0A1L8H5D8	Uncharacterized protein.	BCL9 domain-containing protein.	0.561
A0A1L8ENI4	ccnd1	A0A1L8ENI4	Q8AVQ4	Uncharacterized protein.	Ccnd1-prov protein; Belongs to the cyclin family.	0.853
A0A1L8ENI4	ctnnb1	A0A1L8ENI4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.998