41 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	tmem59l	Uncharacterized protein. (337 aa)
	dkk2	Dickkopf_N domain-containing protein. (255 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	rnf43	RING-type domain-containing protein. (664 aa)
	mesd	Uncharacterized protein. (214 aa)
	Smo.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)
	Fzd6.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
	tspan12-2	Tetraspanin. (304 aa)
	Lgr5.L	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	Ckap4.L	Uncharacterized protein. (548 aa)
	lgr5	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	tspan12	Tetraspanin. (296 aa)
	Smo.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (814 aa)
	Tmem59.L	Uncharacterized protein. (342 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	fzd3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
	fzd6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (724 aa)
	egfr-2	Receptor protein-tyrosine kinase. (1210 aa)
	fzd1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
	Fzd8.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	fzd2	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
	fzd5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	rack1	WD_REPEATS_REGION domain-containing protein. (276 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	egfr	Receptor protein-tyrosine kinase. (1208 aa)
	dkk2-2	Dickkopf homolog 2. (255 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	rack1-2	Gnb2l1-prov protein. (317 aa)
	flot2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	Gapdh.S	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	atp6v1a	MGC114675 protein. (617 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	xfz8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	fz3	Fz3 protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
	znrf3	RING-type domain-containing protein. (854 aa)
	tmem59l-2	Uncharacterized protein. (335 aa)
	Znrf3.S	RING-type domain-containing protein. (848 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Axin1.S	Fzd4.S	A0A1L8ER48	A0A1L8HB90	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.683
Axin1.S	Fzd6.S	A0A1L8ER48	A0A1L8FTP5	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.514
Axin1.S	Fzd8.L	A0A1L8ER48	A0A1L8FVD0	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.670
Axin1.S	Gapdh.S	A0A1L8ER48	Q7ZY52	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.496
Axin1.S	Lgr5.L	A0A1L8ER48	A0A1L8GYN0	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.583
Axin1.S	Lrp5.L	A0A1L8ER48	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.998
Axin1.S	Smo.L	A0A1L8ER48	A0A1L8GZN4	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.551
Axin1.S	Smo.S	A0A1L8ER48	A0A1L8GTP2	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.551
Axin1.S	Znrf3.S	A0A1L8ER48	A0A1L8HQY2	Uncharacterized protein.	RING-type domain-containing protein.	0.668
Axin1.S	actl6a	A0A1L8ER48	Q7ZYI5	Uncharacterized protein.	Baf53a-pending-prov protein; Belongs to the actin family.	0.715
Axin1.S	ctnnb1	A0A1L8ER48	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.999
Axin1.S	dkk1	A0A1L8ER48	A0A1L8FIS6	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.890
Axin1.S	dkk1-2	A0A1L8ER48	O57464	Uncharacterized protein.	Dickkopf homolog 1.	0.892
Axin1.S	dkk2	A0A1L8ER48	A0A1L8HM80	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.712
Axin1.S	dkk2-2	A0A1L8ER48	Q9DDA4	Uncharacterized protein.	Dickkopf homolog 2.	0.711
Axin1.S	egfr	A0A1L8ER48	A0A1L8FRS8	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.428
Axin1.S	egfr-2	A0A1L8ER48	A0A1L8FWP8	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.428
Axin1.S	fz3	A0A1L8ER48	B7ZQS8	Uncharacterized protein.	Fz3 protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.484
Axin1.S	fzd1	A0A1L8ER48	A0A1L8FVQ7	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.813
Axin1.S	fzd2	A0A1L8ER48	A0A1L8EL29	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.834