61 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Slx4ip.S	Uncharacterized protein. (397 aa)
	sumo2	Small ubiquitin-related modifier. (95 aa)
	Sumo1.S	Ubiquitin-like domain-containing protein. (141 aa)
	ube2i	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	Brca1.L	Uncharacterized protein. (1582 aa)
	Eme1.L	ERCC4 domain-containing protein. (411 aa)
	sumo2-2	Ubiquitin-like domain-containing protein. (98 aa)
	Sumo1.L	Ubiquitin-like domain-containing protein. (148 aa)
	Ercc4.L	ERCC4 domain-containing protein. (924 aa)
	slx4	BTB domain-containing protein. (1773 aa)
	Cd40lg.S	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (273 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	mdc1	Uncharacterized protein. (2103 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	xrcc3	RECA_2 domain-containing protein. (360 aa)
	Aicda.S	CMP/dCMP-type deaminase domain-containing protein. (275 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	Aicda.L	CMP/dCMP-type deaminase domain-containing protein. (196 aa)
	ercc1	Uncharacterized protein. (297 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	usp28	USP domain-containing protein; Belongs to the peptidase C19 family. (1015 aa)
	paxip1	Uncharacterized protein. (1334 aa)
	rbbp8	Uncharacterized protein. (846 aa)
	Paxip1.L	Uncharacterized protein. (1320 aa)
	Rbbp8.L	Uncharacterized protein. (856 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa)
	Znf451.L	Uncharacterized protein. (1207 aa)
	rnf168	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (554 aa)
	pxdn	Uncharacterized protein. (1461 aa)
	RNF8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (532 aa)
	rnf168-2	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (565 aa)
	pxdn-2	Uncharacterized protein. (1464 aa)
	terf2	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (466 aa)
	Ccne1.S	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
	rad54l2	Uncharacterized protein. (1396 aa)
	mus81	ERCC4 domain-containing protein. (613 aa)
	ccne1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
	rad54l2-2	Uncharacterized protein. (1393 aa)
	Rhno1.S	Uncharacterized protein. (252 aa)
	pias1	Uncharacterized protein. (640 aa)
	Pias1.L	Uncharacterized protein. (649 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	Rps6kb1.S	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
	Hnrnpa1.S	Uncharacterized protein. (398 aa)
	Ccna1.S	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (418 aa)
	dclre1b	Lactamase_B domain-containing protein. (519 aa)
	rps6kb1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (521 aa)
	Hnrnpa1	Uncharacterized protein. (358 aa)
	Ccna1.L	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (421 aa)
	znf827	Uncharacterized protein. (1317 aa)
	Ccna2.S	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (415 aa)
	smc5	AAA_15 domain-containing protein. (1063 aa)
	znf827-2	Uncharacterized protein. (1317 aa)
	wrn	Uncharacterized protein. (1434 aa)
	slf1	ANK_REP_REGION domain-containing protein. (904 aa)
	trappc13	Uncharacterized protein. (414 aa)
	Pias2.L	Uncharacterized protein. (584 aa)
	TRF2	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (468 aa)
	ccna2	MGC130969 protein; Belongs to the cyclin family. (415 aa)
	lig4	DNA ligase. (911 aa)
	pias3	MGC81944 protein. (633 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Aicda.L	Aicda.S	A0A1L8FIE3	A0A1L8FDV5	CMP/dCMP-type deaminase domain-containing protein.	CMP/dCMP-type deaminase domain-containing protein.	0.900
Aicda.L	Cd40lg.S	A0A1L8FIE3	A0A1L8F3A9	CMP/dCMP-type deaminase domain-containing protein.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.783
Aicda.S	Aicda.L	A0A1L8FDV5	A0A1L8FIE3	CMP/dCMP-type deaminase domain-containing protein.	CMP/dCMP-type deaminase domain-containing protein.	0.900
Aicda.S	Cd40lg.S	A0A1L8FDV5	A0A1L8F3A9	CMP/dCMP-type deaminase domain-containing protein.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.701
Aicda.S	Tp53.L	A0A1L8FDV5	A0A1L8H4M6	CMP/dCMP-type deaminase domain-containing protein.	P53 domain-containing protein.	0.401
Brca1.L	Ccna1.L	A0A1L8ETS4	A0A1L8HIV0	Uncharacterized protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.716
Brca1.L	Ccna1.S	A0A1L8ETS4	A0A1L8HAP9	Uncharacterized protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.716
Brca1.L	Ccna2.S	A0A1L8ETS4	A0A1L8HLX1	Uncharacterized protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.781
Brca1.L	Ccne1.S	A0A1L8ETS4	A0A1L8GF58	Uncharacterized protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.542
Brca1.L	Eme1.L	A0A1L8ETS4	A0A1L8EUA9	Uncharacterized protein.	ERCC4 domain-containing protein.	0.792
Brca1.L	Ercc4.L	A0A1L8ETS4	A0A1L8EXJ6	Uncharacterized protein.	ERCC4 domain-containing protein.	0.808
Brca1.L	Paxip1.L	A0A1L8ETS4	A0A1L8FV59	Uncharacterized protein.	Uncharacterized protein.	0.931
Brca1.L	Pias1.L	A0A1L8ETS4	A0A1L8H180	Uncharacterized protein.	Uncharacterized protein.	0.698
Brca1.L	Pias2.L	A0A1L8ETS4	A0A1L8I3K5	Uncharacterized protein.	Uncharacterized protein.	0.583
Brca1.L	RNF8	A0A1L8ETS4	A0A1L8G6W1	Uncharacterized protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.963
Brca1.L	Rbbp8.L	A0A1L8ETS4	A0A1L8FYP2	Uncharacterized protein.	Uncharacterized protein.	0.999
Brca1.L	Rhno1.S	A0A1L8ETS4	A0A1L8GQX8	Uncharacterized protein.	Uncharacterized protein.	0.624
Brca1.L	Sumo1.L	A0A1L8ETS4	A0A1L8EWZ5	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.712
Brca1.L	Sumo1.S	A0A1L8ETS4	A0A1L8EPQ0	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.712
Brca1.L	TRF2	A0A1L8ETS4	B8QB41	Uncharacterized protein.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.489