22 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	igfbp4	Uncharacterized protein. (255 aa)
	Kremen1.S	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (452 aa)
	dkk2	Dickkopf_N domain-containing protein. (255 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	xfz8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	cdr2	Uncharacterized protein. (450 aa)
	Kremen2.S	Uncharacterized protein. (421 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	Dkk3.S	Dickkopf_N domain-containing protein. (257 aa)
	pxdn-2	Uncharacterized protein. (1464 aa)
	pxdn	Uncharacterized protein. (1461 aa)
	Fzd8.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	Bax.L	Uncharacterized protein. (221 aa)
	kremen2	Uncharacterized protein. (420 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	cdr2-2	Uncharacterized protein. (448 aa)
	igfbp4-2	Uncharacterized protein. (254 aa)
	dkk2-2	Dickkopf homolog 2. (255 aa)
	kremen1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dkk3.S	Fzd8.L	A0A1L8GDZ7	A0A1L8FVD0	Dickkopf_N domain-containing protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.420
Dkk3.S	Kremen1.S	A0A1L8GDZ7	A0A1L8HQW5	Dickkopf_N domain-containing protein.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.761
Dkk3.S	Kremen2.S	A0A1L8GDZ7	A0A1L8ER80	Dickkopf_N domain-containing protein.	Uncharacterized protein.	0.623
Dkk3.S	Lrp5.L	A0A1L8GDZ7	A0A1L8GJX4	Dickkopf_N domain-containing protein.	Uncharacterized protein.	0.873
Dkk3.S	Wnt1.L	A0A1L8GDZ7	A0A1L8HHR8	Dickkopf_N domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.550
Dkk3.S	dkk1	A0A1L8GDZ7	A0A1L8FIS6	Dickkopf_N domain-containing protein.	Dickkopf_N domain-containing protein.	0.917
Dkk3.S	dkk1-2	A0A1L8GDZ7	O57464	Dickkopf_N domain-containing protein.	Dickkopf homolog 1.	0.918
Dkk3.S	dkk2	A0A1L8GDZ7	A0A1L8HM80	Dickkopf_N domain-containing protein.	Dickkopf_N domain-containing protein.	0.926
Dkk3.S	dkk2-2	A0A1L8GDZ7	Q9DDA4	Dickkopf_N domain-containing protein.	Dickkopf homolog 2.	0.926
Dkk3.S	kremen1	A0A1L8GDZ7	A0A1L8I1A4	Dickkopf_N domain-containing protein.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.761
Dkk3.S	kremen2	A0A1L8GDZ7	A0A1L8EYY0	Dickkopf_N domain-containing protein.	Uncharacterized protein.	0.623
Dkk3.S	wnt1	A0A1L8GDZ7	A0A1L8H9S8	Dickkopf_N domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.550
Dkk3.S	wnt3a	A0A1L8GDZ7	A0A1L8FUX8	Dickkopf_N domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.417
Dkk3.S	xfz8	A0A1L8GDZ7	B7ZQV9	Dickkopf_N domain-containing protein.	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family.	0.442
Fzd8.L	Dkk3.S	A0A1L8FVD0	A0A1L8GDZ7	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Dickkopf_N domain-containing protein.	0.420
Fzd8.L	Lrp5.L	A0A1L8FVD0	A0A1L8GJX4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.969
Fzd8.L	Wnt1.L	A0A1L8FVD0	A0A1L8HHR8	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.912
Fzd8.L	dkk1	A0A1L8FVD0	A0A1L8FIS6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Dickkopf_N domain-containing protein.	0.684
Fzd8.L	dkk1-2	A0A1L8FVD0	O57464	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Dickkopf homolog 1.	0.687
Fzd8.L	dkk2	A0A1L8FVD0	A0A1L8HM80	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Dickkopf_N domain-containing protein.	0.549