(53 nodes) (2018) Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals. network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	fosl2	BZIP domain-containing protein. (316 aa)
	Nup153.L	Uncharacterized protein. (1604 aa)
	Itgb1.L	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	Myc.S	Myc_N domain-containing protein. (176 aa)
	twist1	BHLH domain-containing protein. (166 aa)
	itgb1	Integrin beta; Belongs to the integrin beta chain family. (884 aa)
	atad3a	AAA domain-containing protein. (593 aa)
	tubb2b	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (443 aa)
	Cdk1.L	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (333 aa)
	cdk1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
	gpatch4	G-patch domain-containing protein. (322 aa)
	batf	BZIP domain-containing protein. (115 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	Batf.S	BZIP domain-containing protein. (115 aa)
	axin1	Uncharacterized protein. (841 aa)
	Hdac4.L	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1171 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	hdac4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
	Hdac5.S	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1048 aa)
	hdac5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1016 aa)
	c-Jun	C-Jun protein; Belongs to the bZIP family. (312 aa)
	hdac1-2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	ctcf-2	Ctcf protein. (735 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	atf3-2	MGC81814 protein. (181 aa)
	tbp	LOC503680 protein. (296 aa)
	LOC100189571	Uncharacterized protein. (608 aa)
	twist1-2	LOC100036981 protein. (166 aa)
	cdc45	Uncharacterized protein. (567 aa)
	rpl36	60S ribosomal protein L36; Belongs to the eukaryotic ribosomal protein eL36 family. (105 aa)
	Alb.S	Uncharacterized protein. (607 aa)
	hdac7-2	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (957 aa)
	nf1	Uncharacterized protein. (2759 aa)
	mybbp1a	Uncharacterized protein. (1290 aa)
	hdac1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
	Cdk4.L	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (348 aa)
	hdac7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (972 aa)
	Cdk2.S	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
	Hdac3.S	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (405 aa)
	Atf4.L	BZIP domain-containing protein. (343 aa)
	Jun.L	BZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
	cdh3	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	cdh1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
	fosl1-2	BZIP domain-containing protein. (306 aa)
	Atf4.S	BZIP domain-containing protein. (342 aa)
	Cdh3.S	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
	ctcf	Uncharacterized protein. (746 aa)
	fosl1	BZIP domain-containing protein. (261 aa)
	A0A1L8G8Y0	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
	A0A1L8G2V6	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (467 aa)
	atf3	BZIP domain-containing protein. (182 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8G2V6	Batf.S	A0A1L8G2V6	A0A1L8F0K4	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	BZIP domain-containing protein.	0.418
A0A1L8G2V6	Hdac4.L	A0A1L8G2V6	A0A1L8EWI7	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.540
A0A1L8G2V6	Hdac5.S	A0A1L8G2V6	A0A1L8EL25	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.552
A0A1L8G2V6	Jun.L	A0A1L8G2V6	A0A1L8GLZ4	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	BZIP domain-containing protein; Belongs to the bZIP family.	0.533
A0A1L8G2V6	atf3	A0A1L8G2V6	A0A1L8G1E5	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	BZIP domain-containing protein.	0.429
A0A1L8G2V6	atf3-2	A0A1L8G2V6	Q68F43	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	MGC81814 protein.	0.429
A0A1L8G2V6	batf	A0A1L8G2V6	A0A1L8F9C6	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	BZIP domain-containing protein.	0.418
A0A1L8G2V6	c-Jun	A0A1L8G2V6	Q9PVZ1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	C-Jun protein; Belongs to the bZIP family.	0.533
A0A1L8G2V6	fosl2	A0A1L8G2V6	A0A1L8G121	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	BZIP domain-containing protein.	0.516
A0A1L8G2V6	hdac4	A0A1L8G2V6	A0A1L8EPF2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.539
A0A1L8G2V6	hdac5	A0A1L8G2V6	A0A1L8ES84	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.552
A0A1L8G2V6	hdac7	A0A1L8G2V6	A0A1L8H9Z7	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.558
A0A1L8G2V6	hdac7-2	A0A1L8G2V6	A0A1L8HID5	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.558
A0A1L8G2V6	tbp	A0A1L8G2V6	Q5I004	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	LOC503680 protein.	0.414
A0A1L8G8Y0	Batf.S	A0A1L8G8Y0	A0A1L8F0K4	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	BZIP domain-containing protein.	0.418
A0A1L8G8Y0	Hdac4.L	A0A1L8G8Y0	A0A1L8EWI7	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.538
A0A1L8G8Y0	Hdac5.S	A0A1L8G8Y0	A0A1L8EL25	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.550
A0A1L8G8Y0	Jun.L	A0A1L8G8Y0	A0A1L8GLZ4	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	BZIP domain-containing protein; Belongs to the bZIP family.	0.533
A0A1L8G8Y0	atf3	A0A1L8G8Y0	A0A1L8G1E5	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	BZIP domain-containing protein.	0.429
A0A1L8G8Y0	atf3-2	A0A1L8G8Y0	Q68F43	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	MGC81814 protein.	0.429