17 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Myc.S	Myc_N domain-containing protein. (176 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	Gapdh.S	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	pten	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	kremen1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
	Kremen1.S	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (452 aa)
	wif1	Uncharacterized protein. (374 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	mmut	B12-binding domain-containing protein. (758 aa)
	cdh6-2	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
	ezh2	Uncharacterized protein. (748 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	cdh6	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (790 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Gapdh.S	Myc.S	Q7ZY52	A0A1L8FTW7	Glyceraldehyde-3-phosphate dehydrogenase.	Myc_N domain-containing protein.	0.678
Gapdh.S	ctnnb1	Q7ZY52	Q63ZT4	Glyceraldehyde-3-phosphate dehydrogenase.	Beta-catenin protein.	0.924
Gapdh.S	dkk1	Q7ZY52	A0A1L8FIS6	Glyceraldehyde-3-phosphate dehydrogenase.	Dickkopf_N domain-containing protein.	0.555
Gapdh.S	dkk1-2	Q7ZY52	O57464	Glyceraldehyde-3-phosphate dehydrogenase.	Dickkopf homolog 1.	0.559
Gapdh.S	gapdh	Q7ZY52	Q8AY70	Glyceraldehyde-3-phosphate dehydrogenase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.900
Gapdh.S	mmut	Q7ZY52	A0A1L8G5D5	Glyceraldehyde-3-phosphate dehydrogenase.	B12-binding domain-containing protein.	0.738
Gapdh.S	myc	Q7ZY52	Q6NRN4	Glyceraldehyde-3-phosphate dehydrogenase.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.872
Gapdh.S	pten	Q7ZY52	A1L2J3	Glyceraldehyde-3-phosphate dehydrogenase.	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.523
Kremen1.S	Lrp5.L	A0A1L8HQW5	A0A1L8GJX4	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Uncharacterized protein.	0.971
Kremen1.S	ctnnb1	A0A1L8HQW5	Q63ZT4	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Beta-catenin protein.	0.579
Kremen1.S	dkk1	A0A1L8HQW5	A0A1L8FIS6	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Dickkopf_N domain-containing protein.	0.997
Kremen1.S	dkk1-2	A0A1L8HQW5	O57464	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Dickkopf homolog 1.	0.998
Kremen1.S	wif1	A0A1L8HQW5	A0A1L8GYI2	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Uncharacterized protein.	0.498
Kremen1.S	wif1-2	A0A1L8HQW5	B7ZPZ2	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Wnt inhibitory factor-1.	0.498
Lrp5.L	Kremen1.S	A0A1L8GJX4	A0A1L8HQW5	Uncharacterized protein.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.971
Lrp5.L	Myc.S	A0A1L8GJX4	A0A1L8FTW7	Uncharacterized protein.	Myc_N domain-containing protein.	0.551
Lrp5.L	ctnnb1	A0A1L8GJX4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.974
Lrp5.L	dkk1	A0A1L8GJX4	A0A1L8FIS6	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.999
Lrp5.L	dkk1-2	A0A1L8GJX4	O57464	Uncharacterized protein.	Dickkopf homolog 1.	0.999
Lrp5.L	kremen1	A0A1L8GJX4	A0A1L8I1A4	Uncharacterized protein.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.971