92 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fos-2	MGC80305 protein. (368 aa)
	axin2-2	MGC81576 protein. (707 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	ccn2	Ctgf protein. (343 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	wnt7b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	bmp4	Bone morphogenetic protein 4. (401 aa)
	fos	BZIP domain-containing protein. (369 aa)
	slc1a5	Amino acid transporter. (527 aa)
	slc1a3	Amino acid transporter. (592 aa)
	kremen1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
	A0A1L8HYG4	Amino acid transporter. (681 aa)
	vldlr	Uncharacterized protein. (894 aa)
	A0A1L8HXA8	Uncharacterized protein. (896 aa)
	A0A1L8HWZ5	Amino acid transporter. (471 aa)
	A0A1L8HWT0	Amino acid transporter. (562 aa)
	A0A1L8HRR7	Amino acid transporter. (542 aa)
	Kremen1.S	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (452 aa)
	Cer1.S	CTCK domain-containing protein. (338 aa)
	A0A1L8HNG2	Amino acid transporter. (564 aa)
	tnks	Poly [ADP-ribose] polymerase. (1298 aa)
	dkk2	Dickkopf_N domain-containing protein. (255 aa)
	lef1	HMG box domain-containing protein. (372 aa)
	kdr	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1326 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	A0A1L8HE59	Fibrinogen C-terminal domain-containing protein. (502 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	Rcbtb1.S	BTB domain-containing protein. (600 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	A0A1L8H7J8	Fibrinogen C-terminal domain-containing protein. (501 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	epo	Uncharacterized protein. (181 aa)
	Sfrp1.L	Uncharacterized protein. (311 aa)
	Adgra2.L	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1306 aa)
	tspan12-2	Tetraspanin. (304 aa)
	wif1	Uncharacterized protein. (374 aa)
	tspan12	Tetraspanin. (296 aa)
	sfrp1	Uncharacterized protein. (311 aa)
	Wnt5b.S	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
	slc1a7	Amino acid transporter. (564 aa)
	cdh5-2	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (775 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	pax6-2	Uncharacterized protein. (467 aa)
	slc1a2	Amino acid transporter. (568 aa)
	Slc1a7.S	Amino acid transporter. (520 aa)
	tnks2	Poly [ADP-ribose] polymerase. (1165 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	notch1	Uncharacterized protein. (2521 aa)
	pou5f3.2	POU domain protein. (449 aa)
	Pou5f3.1	POU domain protein. (445 aa)
	slc38a5	Aa_trans domain-containing protein. (495 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	A0A1L8EUY4	Uncharacterized protein. (818 aa)
	sox18-2	Uncharacterized protein. (363 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	A0A1L8ENI4	Uncharacterized protein. (815 aa)
	sox18	Uncharacterized protein. (361 aa)
	A0A1L8FNJ4	Amino acid transporter. (557 aa)
	axin2	Uncharacterized protein. (707 aa)
	Sox17a.S	Uncharacterized protein. (377 aa)
	sox17b.1	Uncharacterized protein. (373 aa)
	Myc.S	Myc_N domain-containing protein. (176 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	apcdd1	Uncharacterized protein. (515 aa)
	sox17b.1-2	Uncharacterized protein. (373 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1206 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	A0A1L8G1L8	Calponin-homology (CH) domain-containing protein. (1816 aa)
	angpt2	Fibrinogen C-terminal domain-containing protein. (498 aa)
	sox7	Uncharacterized protein. (363 aa)
	tgfb2-2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	Jag1.L	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
	A0A1L8G7B1	Amino acid transporter. (537 aa)
	A0A1L8G9L4	Fibrinogen C-terminal domain-containing protein. (229 aa)
	sox7-2	Uncharacterized protein. (362 aa)
	Slc1a2.S	Amino acid transporter. (503 aa)
	pax6	Uncharacterized protein. (467 aa)
	Dkk3.S	Dickkopf_N domain-containing protein. (257 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	cdh5	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (774 aa)
	dkk2-2	Dickkopf homolog 2. (255 aa)
	bmp4-2	Bone morphogenetic protein 4. (400 aa)
	lef1-2	Lymphoid enhancer factor XLEF-1. (372 aa)
	cldn5-2	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	slc38a5-2	MGC80848 protein. (495 aa)
	ppara	Ppara protein. (474 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENI4	A0A1L8H5Q6	A0A1L8ENI4	A0A1L8H5Q6	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.998
A0A1L8ENI4	A0A1L8HXA8	A0A1L8ENI4	A0A1L8HXA8	Uncharacterized protein.	Uncharacterized protein.	0.518
A0A1L8ENI4	Dkk3.S	A0A1L8ENI4	A0A1L8GDZ7	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.527
A0A1L8ENI4	Fzd4.S	A0A1L8ENI4	A0A1L8HB90	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.665
A0A1L8ENI4	Jag1.L	A0A1L8ENI4	A0A1L8G723	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.440
A0A1L8ENI4	Lrp5.L	A0A1L8ENI4	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.928
A0A1L8ENI4	Myc.S	A0A1L8ENI4	A0A1L8FTW7	Uncharacterized protein.	Myc_N domain-containing protein.	0.692
A0A1L8ENI4	Notch1.S	A0A1L8ENI4	A0A1L8F124	Uncharacterized protein.	Uncharacterized protein.	0.558
A0A1L8ENI4	Sfrp1.L	A0A1L8ENI4	A0A1L8H1S5	Uncharacterized protein.	Uncharacterized protein.	0.753
A0A1L8ENI4	Wnt1.L	A0A1L8ENI4	A0A1L8HHR8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.872
A0A1L8ENI4	Wnt5b.S	A0A1L8ENI4	A0A1L8GQS0	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.601
A0A1L8ENI4	bmp4	A0A1L8ENI4	B7ZPR8	Uncharacterized protein.	Bone morphogenetic protein 4.	0.569
A0A1L8ENI4	bmp4-2	A0A1L8ENI4	Q91703	Uncharacterized protein.	Bone morphogenetic protein 4.	0.561
A0A1L8ENI4	ctnnb1	A0A1L8ENI4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.998
A0A1L8ENI4	dkk1	A0A1L8ENI4	A0A1L8FIS6	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.899
A0A1L8ENI4	dkk1-2	A0A1L8ENI4	O57464	Uncharacterized protein.	Dickkopf homolog 1.	0.900
A0A1L8ENI4	dkk2	A0A1L8ENI4	A0A1L8HM80	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.665
A0A1L8ENI4	dkk2-2	A0A1L8ENI4	Q9DDA4	Uncharacterized protein.	Dickkopf homolog 2.	0.666
A0A1L8ENI4	jag1	A0A1L8ENI4	A0A1L8G0P5	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.440
A0A1L8ENI4	lef1	A0A1L8ENI4	A0A1L8HM07	Uncharacterized protein.	HMG box domain-containing protein.	0.922