(47 nodes) (2018) Diversity of structure and function of GABAB receptors: a complexity of GABAB-mediated signaling. network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rgs2	RGS domain-containing protein. (216 aa)
	LOC398022	Tyrosine-protein kinase receptor. (1363 aa)
	A0A310U5I6	Arrestin_C domain-containing protein. (388 aa)
	Ckap2.L	CKAP2_C domain-containing protein. (707 aa)
	ckap2	CKAP2_C domain-containing protein. (648 aa)
	kctd12	BTB_2 domain-containing protein. (324 aa)
	camkk1	Protein kinase domain-containing protein. (537 aa)
	cacna1s	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1690 aa)
	Arrb2.L	Arrestin_C domain-containing protein. (446 aa)
	igf1r	Tyrosine-protein kinase receptor. (1358 aa)
	cav2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (160 aa)
	Tm7	Uncharacterized protein; Belongs to the tropomyosin family. (284 aa)
	Cacna1c.S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2146 aa)
	cav3.1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)
	cacna1i	Uncharacterized protein. (2072 aa)
	Atf4.L	BZIP domain-containing protein. (343 aa)
	Rgs2.L	RGS domain-containing protein. (215 aa)
	rgs4-2	RGS domain-containing protein. (244 aa)
	Cacna1e.L	Voltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2255 aa)
	Atf4.S	BZIP domain-containing protein. (342 aa)
	rgs4	RGS domain-containing protein. (242 aa)
	bdnf	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (247 aa)
	Sst.2	Somatostatin domain-containing protein. (157 aa)
	Ptk2.L	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1097 aa)
	usp14	Ubiquitin carboxyl-terminal hydrolase. (490 aa)
	Ptk2.S	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1065 aa)
	Kcnj5.L	Uncharacterized protein. (423 aa)
	shroom4	Uncharacterized protein. (1717 aa)
	Cebpd.S	CCAAT/enhancer-binding protein. (283 aa)
	Cebpb.S	CCAAT/enhancer-binding protein. (288 aa)
	Cacna1b.S	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (1883 aa)
	Rgs6.S	Uncharacterized protein. (394 aa)
	Kcnj3.L	Uncharacterized protein. (489 aa)
	Cebpb.L	CCAAT/enhancer-binding protein. (281 aa)
	kcnj3	Uncharacterized protein. (489 aa)
	Gnas.S	Uncharacterized protein. (217 aa)
	cebpa	CCAAT/enhancer-binding protein. (305 aa)
	Cav-3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (141 aa)
	cav3.2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	sst	Preprosomatostatin 1a. (115 aa)
	cebpd	CCAAT/enhancer-binding protein. (281 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
	cav1a	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	usp14-2	Ubiquitin carboxyl-terminal hydrolase. (489 aa)
	b3gat1l	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (342 aa)
	bdnf-2	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (247 aa)
	kctd12-2	Kctd12 protein. (324 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A310U5I6	Arrb2.L	A0A310U5I6	A0A1L8H368	Arrestin_C domain-containing protein.	Arrestin_C domain-containing protein.	0.901
A0A310U5I6	Gnas.S	A0A310U5I6	A0A1L8ELT4	Arrestin_C domain-containing protein.	Uncharacterized protein.	0.690
A0A310U5I6	Kcnj3.L	A0A310U5I6	A0A1L8EVZ3	Arrestin_C domain-containing protein.	Uncharacterized protein.	0.490
A0A310U5I6	Rgs6.S	A0A310U5I6	A0A1L8EZU1	Arrestin_C domain-containing protein.	Uncharacterized protein.	0.416
A0A310U5I6	cav1	A0A310U5I6	Q6P7G5	Arrestin_C domain-containing protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.441
A0A310U5I6	cav1a	A0A310U5I6	Q6IRP8	Arrestin_C domain-containing protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.445
A0A310U5I6	cav2	A0A310U5I6	A0A1L8GYT2	Arrestin_C domain-containing protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.453
A0A310U5I6	cav3.1	A0A310U5I6	A0A1L8GPP4	Arrestin_C domain-containing protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.441
A0A310U5I6	cav3.2	A0A310U5I6	Q8AVS7	Arrestin_C domain-containing protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.513
A0A310U5I6	kcnj3	A0A310U5I6	A0A1L8EP07	Arrestin_C domain-containing protein.	Uncharacterized protein.	0.487
Arrb2.L	A0A310U5I6	A0A1L8H368	A0A310U5I6	Arrestin_C domain-containing protein.	Arrestin_C domain-containing protein.	0.901
Arrb2.L	Cav-3	A0A1L8H368	Q8JHW9	Arrestin_C domain-containing protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.438
Arrb2.L	Gnas.S	A0A1L8H368	A0A1L8ELT4	Arrestin_C domain-containing protein.	Uncharacterized protein.	0.759
Arrb2.L	Kcnj3.L	A0A1L8H368	A0A1L8EVZ3	Arrestin_C domain-containing protein.	Uncharacterized protein.	0.768
Arrb2.L	Kcnj5.L	A0A1L8H368	A0A1L8FL58	Arrestin_C domain-containing protein.	Uncharacterized protein.	0.481
Arrb2.L	LOC398022	A0A1L8H368	B7ZSL0	Arrestin_C domain-containing protein.	Tyrosine-protein kinase receptor.	0.432
Arrb2.L	Rgs2.L	A0A1L8H368	A0A1L8GNL4	Arrestin_C domain-containing protein.	RGS domain-containing protein.	0.654
Arrb2.L	Rgs6.S	A0A1L8H368	A0A1L8EZU1	Arrestin_C domain-containing protein.	Uncharacterized protein.	0.481
Arrb2.L	Tm7	A0A1L8H368	A0A1L8GTE7	Arrestin_C domain-containing protein.	Uncharacterized protein; Belongs to the tropomyosin family.	0.445
Arrb2.L	cav1	A0A1L8H368	Q6P7G5	Arrestin_C domain-containing protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.442