(35 nodes) (2019) The evolution of transcriptional repressors in the Notch signaling pathway: a computational analysis. network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ep300	Uncharacterized protein. (2495 aa)
	asf1a	Uncharacterized protein. (201 aa)
	Rbbp8.L	Uncharacterized protein. (856 aa)
	rbbp8	Uncharacterized protein. (846 aa)
	A0A1L8FJ10	Uncharacterized protein. (987 aa)
	ctbp2	Uncharacterized protein. (973 aa)
	dmpk-2	Uncharacterized protein. (588 aa)
	notch1	Uncharacterized protein. (2521 aa)
	dmpk	Uncharacterized protein. (588 aa)
	ctbp2l-2	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (437 aa)
	crebbp-2	Uncharacterized protein. (2453 aa)
	crebbp	Uncharacterized protein. (2424 aa)
	ep300-2	Uncharacterized protein. (2492 aa)
	Ank1.L	Uncharacterized protein. (1649 aa)
	ctbp2l	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (480 aa)
	msx2	Homeobox domain-containing protein. (257 aa)
	msx2-2	Homeobox domain-containing protein. (257 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	sin3a	HDAC_interact domain-containing protein. (1273 aa)
	maml2	MamL-1 domain-containing protein. (994 aa)
	Cbs.L	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (565 aa)
	hdac1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (830 aa)
	maml2-2	MamL-1 domain-containing protein. (995 aa)
	Rbpj.S	Uncharacterized protein. (485 aa)
	A0A1L8HLU1	MamL-1 domain-containing protein. (1090 aa)
	ctbp1	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (441 aa)
	rbpj	Uncharacterized protein. (487 aa)
	A0A1L8HUL3	Uncharacterized protein. (668 aa)
	Sugp1.L	Uncharacterized protein. (620 aa)
	Prickle3.L	Uncharacterized protein. (437 aa)
	XMam1	XMam1 protein. (1039 aa)
	LOC494997	LOC494997 protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (430 aa)
	cbs	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (562 aa)
	hdac1-2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FJ10	Cbs.L	A0A1L8FJ10	A0A1L8HBN5	Uncharacterized protein.	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.430
A0A1L8FJ10	Rbbp8.L	A0A1L8FJ10	A0A1L8FYP2	Uncharacterized protein.	Uncharacterized protein.	0.918
A0A1L8FJ10	Rbpj.S	A0A1L8FJ10	A0A1L8HL49	Uncharacterized protein.	Uncharacterized protein.	0.934
A0A1L8FJ10	cbs	A0A1L8FJ10	Q6DDN9	Uncharacterized protein.	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.430
A0A1L8FJ10	crebbp	A0A1L8FJ10	A0A1L8EQR2	Uncharacterized protein.	Uncharacterized protein.	0.512
A0A1L8FJ10	crebbp-2	A0A1L8FJ10	A0A1L8EYE5	Uncharacterized protein.	Uncharacterized protein.	0.512
A0A1L8FJ10	ep300	A0A1L8FJ10	A0A1L8GGW2	Uncharacterized protein.	Uncharacterized protein.	0.509
A0A1L8FJ10	ep300-2	A0A1L8FJ10	A0A1L8GNI9	Uncharacterized protein.	Uncharacterized protein.	0.509
A0A1L8FJ10	hdac1	A0A1L8FJ10	A0A1L8HFI8	Uncharacterized protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.946
A0A1L8FJ10	hdac1-2	A0A1L8FJ10	Q7ZYT5	Uncharacterized protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.946
A0A1L8FJ10	kdm1a	A0A1L8FJ10	A0A1L8HFM2	Uncharacterized protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.700
A0A1L8FJ10	rbbp8	A0A1L8FJ10	A0A1L8FSU5	Uncharacterized protein.	Uncharacterized protein.	0.918
A0A1L8FJ10	rbpj	A0A1L8FJ10	A0A1L8HTS9	Uncharacterized protein.	Uncharacterized protein.	0.934
A0A1L8HLU1	Ank1.L	A0A1L8HLU1	A0A1L8GRL3	MamL-1 domain-containing protein.	Uncharacterized protein.	0.563
A0A1L8HLU1	Notch1.S	A0A1L8HLU1	A0A1L8F124	MamL-1 domain-containing protein.	Uncharacterized protein.	0.928
A0A1L8HLU1	Rbpj.S	A0A1L8HLU1	A0A1L8HL49	MamL-1 domain-containing protein.	Uncharacterized protein.	0.998
A0A1L8HLU1	crebbp	A0A1L8HLU1	A0A1L8EQR2	MamL-1 domain-containing protein.	Uncharacterized protein.	0.881
A0A1L8HLU1	crebbp-2	A0A1L8HLU1	A0A1L8EYE5	MamL-1 domain-containing protein.	Uncharacterized protein.	0.881
A0A1L8HLU1	ep300	A0A1L8HLU1	A0A1L8GGW2	MamL-1 domain-containing protein.	Uncharacterized protein.	0.886
A0A1L8HLU1	ep300-2	A0A1L8HLU1	A0A1L8GNI9	MamL-1 domain-containing protein.	Uncharacterized protein.	0.886