(51 nodes) (2019) Connecting muscle development, birth defects, and evolution: An essential role for muscle connective tissue. network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hoxa11	Homeobox domain-containing protein. (298 aa)
	dlx5	Homeobox domain-containing protein. (297 aa)
	Tcf7l2.L	HMG box domain-containing protein. (482 aa)
	lhx2	Uncharacterized protein. (415 aa)
	Cxcr4.L	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	Fn1.S	Uncharacterized protein. (2480 aa)
	cxcr4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	myog	Myogenin U1. (235 aa)
	epha4	Pag protein. (986 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	lhx2-2	LIM homeobox protein 2. (419 aa)
	gata4-2	MGC81427 protein. (394 aa)
	pitx2	Homeobox protein. (323 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	myf6	Myogenic factor. (241 aa)
	hoxd11	MGC131014 protein. (274 aa)
	myod1-a	Myoblast determination protein 1 homolog A; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (289 aa)
	cdh11-2	Cadherin; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)
	scx	Scleraxis. (180 aa)
	XMyf-5	Myogenic factor. (255 aa)
	tbx5-2	T-box transcription factor Tbx5. (519 aa)
	bmp4-2	Bone morphogenetic protein 4. (400 aa)
	Tbx1	T-box transcription factor. (463 aa)
	tbx3	Transcription factor Tbx3. (711 aa)
	MRF4	MRF4a. (240 aa)
	bmp4	Bone morphogenetic protein 4. (401 aa)
	tbx1	Uncharacterized protein. (463 aa)
	Pitx2.S	Homeobox protein. (326 aa)
	pdgfra-2	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1087 aa)
	Efna5.S	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (185 aa)
	tbx5	Uncharacterized protein. (519 aa)
	pdgfra	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
	tbx4	Uncharacterized protein. (541 aa)
	Myog.S	BHLH domain-containing protein. (236 aa)
	hgf-2	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
	myf5	Myogenic factor. (255 aa)
	hgf	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
	Myod1.L	Myogenic factor. (289 aa)
	osr1-2	Uncharacterized protein. (259 aa)
	Pax3.L	Uncharacterized protein. (590 aa)
	tcf21	BHLH domain-containing protein. (179 aa)
	gata4	Uncharacterized protein. (392 aa)
	osr1	Uncharacterized protein. (259 aa)
	Pax3.S	Uncharacterized protein. (592 aa)
	Epha4.L	Uncharacterized protein. (1022 aa)
	Scx.L	BHLH domain-containing protein. (180 aa)
	hoxa11-2	Homeobox domain-containing protein. (299 aa)
	Dlx5.L	Homeobox domain-containing protein. (298 aa)
	osr2	Uncharacterized protein. (271 aa)
	cdh2	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (947 aa)
	Tgfbr1.S	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (454 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cxcr4.L	actl6a	A0A1L8EVR7	Q7ZYI5	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Baf53a-pending-prov protein; Belongs to the actin family.	0.474
Cxcr4.L	bmp4	A0A1L8EVR7	B7ZPR8	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Bone morphogenetic protein 4.	0.508
Cxcr4.L	bmp4-2	A0A1L8EVR7	Q91703	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Bone morphogenetic protein 4.	0.512
Cxcr4.L	cdh2	A0A1L8EVR7	A0A1L8FSZ9	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.441
Cxcr4.L	ctnnb1	A0A1L8EVR7	Q63ZT4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Beta-catenin protein.	0.529
Cxcr4.L	cxcr4	A0A1L8EVR7	A0A1L8ENZ5	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.900
Cxcr4.L	gata4	A0A1L8EVR7	A0A1L8G5M0	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.432
Cxcr4.L	gata4-2	A0A1L8EVR7	Q6GR12	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	MGC81427 protein.	0.432
Cxcr4.L	hgf	A0A1L8EVR7	A0A1L8GTY1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.546
Cxcr4.L	hgf-2	A0A1L8EVR7	A0A1L8GZD1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.546
Dlx5.L	MRF4	A0A1L8FVV2	B7ZQB0	Homeobox domain-containing protein.	MRF4a.	0.464
Dlx5.L	bmp4	A0A1L8FVV2	B7ZPR8	Homeobox domain-containing protein.	Bone morphogenetic protein 4.	0.703
Dlx5.L	bmp4-2	A0A1L8FVV2	Q91703	Homeobox domain-containing protein.	Bone morphogenetic protein 4.	0.700
Dlx5.L	ctnnb1	A0A1L8FVV2	Q63ZT4	Homeobox domain-containing protein.	Beta-catenin protein.	0.468
Dlx5.L	myf6	A0A1L8FVV2	Q5U4S0	Homeobox domain-containing protein.	Myogenic factor.	0.455
Efna5.S	Epha4.L	A0A1L8HR32	A0A1L8G4M3	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	Uncharacterized protein.	0.995
Efna5.S	actl6a	A0A1L8HR32	Q7ZYI5	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	Baf53a-pending-prov protein; Belongs to the actin family.	0.428
Efna5.S	epha4	A0A1L8HR32	Q7ZYM7	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	Pag protein.	0.995
Efna5.S	pdgfra	A0A1L8HR32	A0A1L8HLA2	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.650
Efna5.S	pdgfra-2	A0A1L8HR32	A0A1L8HTV1	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.650