(47 nodes) (2019) The Wnt inhibitor Dkk1 is required for maintaining the normal cardiac differentiation program in Xenopus laevis. network (Xenopus laevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tbxt-2	MGC81453 protein. (432 aa)
	h3f3b	Histone H3; Belongs to the histone H3 family. (136 aa)
	Frzb.S	Uncharacterized protein. (319 aa)
	Frzb-1	Uncharacterized protein. (319 aa)
	A0A1L8EY07	Histone H3; Belongs to the histone H3 family. (120 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	Hprt1.L	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (289 aa)
	prkg1	cGMP-dependent protein kinase. (673 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	Tnni3.L	Uncharacterized protein. (238 aa)
	gata6	Uncharacterized protein. (502 aa)
	hist2h3c	Histone H3; Belongs to the histone H3 family. (136 aa)
	tbxt	Uncharacterized protein. (432 aa)
	Agxt.S	Aminotran_5 domain-containing protein. (258 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	sfrp1	Uncharacterized protein. (311 aa)
	nkx2-5	Homeobox domain-containing protein. (300 aa)
	Sfrp1.L	Uncharacterized protein. (311 aa)
	Alcam.L	Uncharacterized protein. (573 aa)
	casp3.2	Uncharacterized protein; Belongs to the peptidase C14A family. (288 aa)
	lef1	HMG box domain-containing protein. (372 aa)
	dkk2	Dickkopf_N domain-containing protein. (255 aa)
	Myh6.S	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1934 aa)
	A0A1L8HPW4	Uncharacterized protein. (216 aa)
	tbx5	Uncharacterized protein. (519 aa)
	mef2c	MADS-box domain-containing protein. (464 aa)
	Casp3.L	Uncharacterized protein; Belongs to the peptidase C14A family. (253 aa)
	lif	Uncharacterized protein. (216 aa)
	tbx1	Uncharacterized protein. (463 aa)
	mef2c-2	MADS-box domain-containing protein. (464 aa)
	A0A310TTQ1	Histone H3; Belongs to the histone H3 family. (136 aa)
	bmp4	Bone morphogenetic protein 4. (401 aa)
	Tbx1	T-box transcription factor. (463 aa)
	LOC100189571	Uncharacterized protein. (608 aa)
	tbx5-2	T-box transcription factor Tbx5. (519 aa)
	LOC397803	Cardiac troponin I. (244 aa)
	mespa	BHLH transcription factor mespa. (283 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	alcam	MGC84135 protein. (570 aa)
	nkx2-5-2	Nkx2.5 protein. (299 aa)
	Gapdh.S	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	lef1-2	Lymphoid enhancer factor XLEF-1. (372 aa)
	bmp4-2	Bone morphogenetic protein 4. (400 aa)
	dkk2-2	Dickkopf homolog 2. (255 aa)
	agxt	Serine--pyruvate aminotransferase. (415 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EY07	Casp3.L	A0A1L8EY07	A0A1L8HU08	Histone H3; Belongs to the histone H3 family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.908
A0A1L8EY07	Gapdh.S	A0A1L8EY07	Q7ZY52	Histone H3; Belongs to the histone H3 family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.851
A0A1L8EY07	LOC100189571	A0A1L8EY07	B7ZRX0	Histone H3; Belongs to the histone H3 family.	Uncharacterized protein.	0.791
A0A1L8EY07	casp3.2	A0A1L8EY07	A0A1L8HLJ6	Histone H3; Belongs to the histone H3 family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.908
A0A1L8EY07	ctnnb1	A0A1L8EY07	Q63ZT4	Histone H3; Belongs to the histone H3 family.	Beta-catenin protein.	0.729
A0A1L8EY07	gapdh	A0A1L8EY07	Q8AY70	Histone H3; Belongs to the histone H3 family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.851
A0A1L8EY07	gata6	A0A1L8EY07	A0A1L8FSX7	Histone H3; Belongs to the histone H3 family.	Uncharacterized protein.	0.494
A0A1L8EY07	lef1	A0A1L8EY07	A0A1L8HM07	Histone H3; Belongs to the histone H3 family.	HMG box domain-containing protein.	0.453
A0A1L8EY07	lef1-2	A0A1L8EY07	Q90ZB8	Histone H3; Belongs to the histone H3 family.	Lymphoid enhancer factor XLEF-1.	0.451
A0A1L8HPW4	Gapdh.S	A0A1L8HPW4	Q7ZY52	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.428
A0A1L8HPW4	LOC100189571	A0A1L8HPW4	B7ZRX0	Uncharacterized protein.	Uncharacterized protein.	0.406
A0A1L8HPW4	bmp4	A0A1L8HPW4	B7ZPR8	Uncharacterized protein.	Bone morphogenetic protein 4.	0.560
A0A1L8HPW4	bmp4-2	A0A1L8HPW4	Q91703	Uncharacterized protein.	Bone morphogenetic protein 4.	0.586
A0A1L8HPW4	gapdh	A0A1L8HPW4	Q8AY70	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.429
A0A1L8HPW4	lif	A0A1L8HPW4	A0A1L8HZU9	Uncharacterized protein.	Uncharacterized protein.	0.901
A0A310TTQ1	Casp3.L	A0A310TTQ1	A0A1L8HU08	Histone H3; Belongs to the histone H3 family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.908
A0A310TTQ1	Gapdh.S	A0A310TTQ1	Q7ZY52	Histone H3; Belongs to the histone H3 family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.851
A0A310TTQ1	LOC100189571	A0A310TTQ1	B7ZRX0	Histone H3; Belongs to the histone H3 family.	Uncharacterized protein.	0.791
A0A310TTQ1	casp3.2	A0A310TTQ1	A0A1L8HLJ6	Histone H3; Belongs to the histone H3 family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.908
A0A310TTQ1	ctnnb1	A0A310TTQ1	Q63ZT4	Histone H3; Belongs to the histone H3 family.	Beta-catenin protein.	0.729