19 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rad50-2	Zinc-hook domain-containing protein. (1312 aa)
	Rpa1.L	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (609 aa)
	Orc2.S	Uncharacterized protein. (558 aa)
	rmi2	Uncharacterized protein. (152 aa)
	Endog.L	Endonuclease. (290 aa)
	Dna2.S	Uncharacterized protein. (1053 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	Nbn.L	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa)
	topbp1	Uncharacterized protein. (1573 aa)
	Atr.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa)
	atrip	Uncharacterized protein. (801 aa)
	mcm2	DNA helicase; Belongs to the MCM family. (885 aa)
	cdc45	Uncharacterized protein. (567 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)
	Mcm2.L	DNA helicase; Belongs to the MCM family. (886 aa)
	Rad26	Uncharacterized protein. (798 aa)
	rad50	Zinc-hook domain-containing protein. (1311 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atr.L	Dna2.S	A0A1L8GAP7	A0A1L8FF41	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.982
Atr.L	Hus1	A0A1L8GAP7	Q8JHD8	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Checkpoint protein; Belongs to the HUS1 family.	0.999
Atr.L	Mcm2.L	A0A1L8GAP7	A0A1L8GPN4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	DNA helicase; Belongs to the MCM family.	0.838
Atr.L	Nbn.L	A0A1L8GAP7	A0A1L8FZE8	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.990
Atr.L	Orc2.S	A0A1L8GAP7	A0A1L8EPN0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.863
Atr.L	Rad26	A0A1L8GAP7	A0A1L8GP12	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.999
Atr.L	Rpa1.L	A0A1L8GAP7	A0A1L8HDB4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.993
Atr.L	atrip	A0A1L8GAP7	A0A1L8GH95	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.999
Atr.L	cdc45	A0A1L8GAP7	A0A1L8I0M4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.960
Atr.L	chek1	A0A1L8GAP7	A0A1L8FFS1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.999
Atr.L	chek1-2	A0A1L8GAP7	A0A1L8FL95	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Protein kinase domain-containing protein.	0.999
Atr.L	mcm2	A0A1L8GAP7	A0A1L8GHP1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	DNA helicase; Belongs to the MCM family.	0.893
Atr.L	rad50	A0A1L8GAP7	A0A1L8GVF0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Zinc-hook domain-containing protein.	0.955
Atr.L	rad50-2	A0A1L8GAP7	A0A1L8GXM0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Zinc-hook domain-containing protein.	0.955
Atr.L	rad9a	A0A1L8GAP7	Q7ZZU5	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.998
Atr.L	rmi2	A0A1L8GAP7	A0A1L8EXN1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.754
Atr.L	topbp1	A0A1L8GAP7	A0A1L8FWJ6	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.999
Dna2.S	Atr.L	A0A1L8FF41	A0A1L8GAP7	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.982
Dna2.S	Endog.L	A0A1L8FF41	A0A1L8F798	Uncharacterized protein.	Endonuclease.	0.479
Dna2.S	Hus1	A0A1L8FF41	Q8JHD8	Uncharacterized protein.	Checkpoint protein; Belongs to the HUS1 family.	0.950