22 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	poli	UmuC domain-containing protein. (737 aa)
	A0A1L8HPJ8	Ubiquitin-like domain-containing protein. (125 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	mdm2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
	RNF8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (532 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa)
	top2b	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1696 aa)
	Myc.S	Myc_N domain-containing protein. (176 aa)
	Tdp2.S	Endo/exonuclease/phosphatase domain-containing protein. (382 aa)
	A0A1L8FRI6	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1695 aa)
	Hspa8.L	Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
	Fbl.S	Uncharacterized protein. (320 aa)
	Sumo1.L	Ubiquitin-like domain-containing protein. (148 aa)
	ubtf	Uncharacterized protein. (677 aa)
	Sumo1.S	Ubiquitin-like domain-containing protein. (141 aa)
	sumo2	Small ubiquitin-related modifier. (95 aa)
	hspa1l	Hsc70 protein; Belongs to the heat shock protein 70 family. (650 aa)
	ubtf-2	Ubtf-b protein. (701 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	top2a	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1579 aa)
	LOC496290	LOC496290 protein. (461 aa)
	Fus.L	Uncharacterized protein. (511 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FRI6	Fbl.S	A0A1L8FRI6	A0A1L8FHU5	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Uncharacterized protein.	0.418
A0A1L8FRI6	Sumo1.L	A0A1L8FRI6	A0A1L8EWZ5	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Ubiquitin-like domain-containing protein.	0.754
A0A1L8FRI6	Sumo1.S	A0A1L8FRI6	A0A1L8EPQ0	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Ubiquitin-like domain-containing protein.	0.754
A0A1L8FRI6	Tdp2.S	A0A1L8FRI6	A0A1L8FSF5	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Endo/exonuclease/phosphatase domain-containing protein.	0.781
A0A1L8FRI6	poli	A0A1L8FRI6	A0A1L8HRY0	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	UmuC domain-containing protein.	0.496
A0A1L8FRI6	sumo2	A0A1L8FRI6	A0A1L8EMU2	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Small ubiquitin-related modifier.	0.829
A0A1L8HPJ8	Fbl.S	A0A1L8HPJ8	A0A1L8FHU5	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.540
A0A1L8HPJ8	RNF8	A0A1L8HPJ8	A0A1L8G6W1	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.637
A0A1L8HPJ8	Sumo1.L	A0A1L8HPJ8	A0A1L8EWZ5	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.924
A0A1L8HPJ8	Sumo1.S	A0A1L8HPJ8	A0A1L8EPQ0	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.924
A0A1L8HPJ8	Tp53.L	A0A1L8HPJ8	A0A1L8H4M6	Ubiquitin-like domain-containing protein.	P53 domain-containing protein.	0.580
A0A1L8HPJ8	hspa1l	A0A1L8HPJ8	Q8AVE2	Ubiquitin-like domain-containing protein.	Hsc70 protein; Belongs to the heat shock protein 70 family.	0.439
A0A1L8HPJ8	mdm2	A0A1L8HPJ8	A0A1L8GYI7	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.564
A0A1L8HPJ8	poli	A0A1L8HPJ8	A0A1L8HRY0	Ubiquitin-like domain-containing protein.	UmuC domain-containing protein.	0.496
A0A1L8HPJ8	rnf8	A0A1L8HPJ8	A0A1L8G0Z4	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.637
A0A1L8HPJ8	sumo2	A0A1L8HPJ8	A0A1L8EMU2	Ubiquitin-like domain-containing protein.	Small ubiquitin-related modifier.	0.965
Fbl.S	A0A1L8FRI6	A0A1L8FHU5	A0A1L8FRI6	Uncharacterized protein.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.418
Fbl.S	A0A1L8HPJ8	A0A1L8FHU5	A0A1L8HPJ8	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.540
Fbl.S	poli	A0A1L8FHU5	A0A1L8HRY0	Uncharacterized protein.	UmuC domain-containing protein.	0.614
Fbl.S	top2a	A0A1L8FHU5	Q6INT0	Uncharacterized protein.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.418