57 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	ercc1	Uncharacterized protein. (297 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	A0A1L8FFG3	Uncharacterized protein. (504 aa)
	Dna2.S	Uncharacterized protein. (1053 aa)
	Fancm.L	Uncharacterized protein. (2165 aa)
	fancf	Uncharacterized protein. (348 aa)
	top3a	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1022 aa)
	plk1	Serine/threonine-protein kinase PLK. (598 aa)
	usp7-2	Usp7; Belongs to the peptidase C19 family. (1124 aa)
	Sumo1.L	Ubiquitin-like domain-containing protein. (148 aa)
	top1.1	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (821 aa)
	rtel1	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1275 aa)
	Cdc6.L	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (645 aa)
	Plk1.S	Serine/threonine-protein kinase PLK. (598 aa)
	usp7	Uncharacterized protein; Belongs to the peptidase C19 family. (1123 aa)
	Sumo1.S	Ubiquitin-like domain-containing protein. (141 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	prpf19	Nmp200-prov protein. (504 aa)
	ufd1-2	MGC68571 protein. (307 aa)
	faf1	MGC80303 protein. (655 aa)
	top2a	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1579 aa)
	ufd1	Uncharacterized protein. (307 aa)
	rnf4	LOC495944 protein. (190 aa)
	Fanca.L	Fanconi_A_N domain-containing protein. (1423 aa)
	Skp2.L	F-box domain-containing protein. (420 aa)
	cdc45	Uncharacterized protein. (567 aa)
	Top3b.L	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (824 aa)
	fancc	Uncharacterized protein. (551 aa)
	Pias4.L	Uncharacterized protein. (544 aa)
	neil3	Uncharacterized protein. (616 aa)
	Rnf4-a	RING-type domain-containing protein. (190 aa)
	fancg	TPR_REGION domain-containing protein. (640 aa)
	Rpa1.L	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (609 aa)
	brca2	Tower domain-containing protein. (3177 aa)
	Cdk2.S	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
	ube2t	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (192 aa)
	Pias1.L	Uncharacterized protein. (649 aa)
	fanci	Uncharacterized protein. (1337 aa)
	skp1-2	Uncharacterized protein; Belongs to the SKP1 family. (221 aa)
	pias1	Uncharacterized protein. (640 aa)
	A0A1L8GS29	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (268 aa)
	skp1	Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
	fancd2	Uncharacterized protein. (1445 aa)
	Rad26	Uncharacterized protein. (798 aa)
	atrip	Uncharacterized protein. (801 aa)
	Faf1.S	UBX domain-containing protein. (657 aa)
	top1.2	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (770 aa)
	usp1	Ubiquitin carboxyl-terminal hydrolase. (766 aa)
	Fancl.L	RING-type domain-containing protein. (361 aa)
	sde2-2	Sde2_N_Ubi domain-containing protein. (447 aa)
	Dtl.L	WD_REPEATS_REGION domain-containing protein. (711 aa)
	Senp6.S	ULP_PROTEASE domain-containing protein. (1103 aa)
	sprtn	Uncharacterized protein. (565 aa)
	dtl	WD_REPEATS_REGION domain-containing protein. (710 aa)
	sde2	Sde2_N_Ubi domain-containing protein. (454 aa)
	Xrcc2.S	RECA_2 domain-containing protein. (223 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FFG3	Dtl.L	A0A1L8FFG3	A0A1L8G665	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.472
A0A1L8FFG3	Faf1.S	A0A1L8FFG3	A0A1L8GFV4	Uncharacterized protein.	UBX domain-containing protein.	0.420
A0A1L8FFG3	Rpa1.L	A0A1L8FFG3	A0A1L8HDB4	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.691
A0A1L8FFG3	Senp6.S	A0A1L8FFG3	A0A1L8G3E0	Uncharacterized protein.	ULP_PROTEASE domain-containing protein.	0.676
A0A1L8FFG3	dtl	A0A1L8FFG3	A0A1L8G1C0	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.472
A0A1L8FFG3	faf1	A0A1L8FFG3	Q6INU5	Uncharacterized protein.	MGC80303 protein.	0.420
A0A1L8FFG3	prpf19	A0A1L8FFG3	Q7ZXW4	Uncharacterized protein.	Nmp200-prov protein.	0.900
A0A1L8FFG3	sde2	A0A1L8FFG3	A0A1L8G160	Uncharacterized protein.	Sde2_N_Ubi domain-containing protein.	0.870
A0A1L8FFG3	sde2-2	A0A1L8FFG3	A0A1L8G6M9	Uncharacterized protein.	Sde2_N_Ubi domain-containing protein.	0.870
A0A1L8GS29	Cdc6.L	A0A1L8GS29	A0A1L8ES00	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.585
A0A1L8GS29	Cdk2.S	A0A1L8GS29	A0A1L8H9N1	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.614
A0A1L8GS29	Dna2.S	A0A1L8GS29	A0A1L8FF41	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.794
A0A1L8GS29	Dtl.L	A0A1L8GS29	A0A1L8G665	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	WD_REPEATS_REGION domain-containing protein.	0.965
A0A1L8GS29	Fancm.L	A0A1L8GS29	A0A1L8F9Q1	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.981
A0A1L8GS29	Pias1.L	A0A1L8GS29	A0A1L8H180	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.643
A0A1L8GS29	Pias4.L	A0A1L8GS29	A0A1L8HW74	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.643
A0A1L8GS29	Rpa1.L	A0A1L8GS29	A0A1L8HDB4	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.936
A0A1L8GS29	Sumo1.L	A0A1L8GS29	A0A1L8EWZ5	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Ubiquitin-like domain-containing protein.	0.911
A0A1L8GS29	Sumo1.S	A0A1L8GS29	A0A1L8EPQ0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Ubiquitin-like domain-containing protein.	0.911
A0A1L8GS29	Top3b.L	A0A1L8GS29	A0A1L8I0K8	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.753