(54 nodes) (2019) CREB3 Transcription Factors: ER-Golgi Stress Transducers as Hubs for Cellular Homeostasis. network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Cxcr4.L	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	Col1a1.S	Uncharacterized protein. (1449 aa)
	ihh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
	cxcr4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	col1a1	Uncharacterized protein. (1449 aa)
	ihh-2	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
	tfe3	BHLH domain-containing protein. (513 aa)
	Hif-1a	Uncharacterized protein. (800 aa)
	Hcfc1.S	Uncharacterized protein. (2098 aa)
	creb3l4	BZIP domain-containing protein. (434 aa)
	A0A1L8F712	Serine protease; Belongs to the peptidase S1B family. (349 aa)
	crp.4	Pentaxin. (242 aa)
	creb3l4-2	BZIP domain-containing protein. (458 aa)
	Sec24d.S	Uncharacterized protein. (1126 aa)
	atf6	BZIP domain-containing protein. (635 aa)
	sox10	HMG box domain-containing protein. (438 aa)
	creb3l1	BZIP domain-containing protein. (474 aa)
	atf6-2	BZIP domain-containing protein. (646 aa)
	sox10-2	HMG box domain-containing protein. (446 aa)
	skp1	Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
	Hdac3.S	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (405 aa)
	skp1-2	Uncharacterized protein; Belongs to the SKP1 family. (221 aa)
	A0A1L8GY45	Uncharacterized protein. (780 aa)
	frs2	IRS-type PTB domain-containing protein. (518 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	gabpa	Uncharacterized protein. (454 aa)
	tshb	Cys_knot domain-containing protein. (141 aa)
	klhl12	BTB domain-containing protein. (564 aa)
	Nr4a1.S	Uncharacterized protein. (653 aa)
	Sp7.S	Uncharacterized protein. (409 aa)
	tshb-2	Cys_knot domain-containing protein. (141 aa)
	klhl12-2	BTB domain-containing protein. (564 aa)
	nr4a1	Uncharacterized protein. (584 aa)
	col2a1	Uncharacterized protein. (1486 aa)
	Serpinh1.L	SERPIN domain-containing protein; Belongs to the serpin family. (459 aa)
	uso1	Uncharacterized protein. (954 aa)
	fbxw7	Uncharacterized protein. (706 aa)
	sec24d	Uncharacterized protein. (1025 aa)
	uso1-2	Uncharacterized protein. (966 aa)
	Nfil3	Nuclear factor interleukin-3-regulated protein; May act as a transcriptional regulator of a number of proteins of the circadian clock; Belongs to the bZIP family. NFIL3 subfamily. (456 aa)
	Fus.L	Uncharacterized protein. (511 aa)
	Hist2h2ab.S	Histone H2A; Belongs to the histone H2A family. (139 aa)
	arf4	Arf4 protein; Belongs to the small GTPase superfamily. Arf family. (180 aa)
	sox9-a	Sex determining region Y-box 9. (477 aa)
	copb1	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (953 aa)
	ccr2	LOC494705 protein; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	atf5.2	Atf5-prov protein. (308 aa)
	gabpa-2	Gabpa-prov protein. (452 aa)
	copb1-2	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (960 aa)
	hif1a	Hif1a-prov protein. (802 aa)
	serpinh1	Hsp47-prov protein; Belongs to the serpin family. (419 aa)
	hspa5-2	Hspa5 protein; Belongs to the heat shock protein 70 family. (655 aa)
	creb1	Creb1-prov protein. (324 aa)
	thibz	Leucine zipper. (331 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8GY45	Hcfc1.S	A0A1L8GY45	A0A1L8F1Q9	Uncharacterized protein.	Uncharacterized protein.	0.902
A0A1L8GY45	creb3l4	A0A1L8GY45	A0A1L8F529	Uncharacterized protein.	BZIP domain-containing protein.	0.532
A0A1L8GY45	creb3l4-2	A0A1L8GY45	A0A1L8FD74	Uncharacterized protein.	BZIP domain-containing protein.	0.532
A0A1L8GY45	thibz	A0A1L8GY45	Q91640	Uncharacterized protein.	Leucine zipper.	0.436
Col1a1.S	Sec24d.S	A0A1L8EL23	A0A1L8FF45	Uncharacterized protein.	Uncharacterized protein.	0.574
Col1a1.S	Serpinh1.L	A0A1L8EL23	A0A1L8HJY3	Uncharacterized protein.	SERPIN domain-containing protein; Belongs to the serpin family.	0.592
Col1a1.S	Sp7.S	A0A1L8EL23	A0A1L8HA54	Uncharacterized protein.	Uncharacterized protein.	0.444
Col1a1.S	creb3l1	A0A1L8EL23	A0A1L8GIS4	Uncharacterized protein.	BZIP domain-containing protein.	0.671
Col1a1.S	sec24d	A0A1L8EL23	A0A1L8HUY0	Uncharacterized protein.	Uncharacterized protein.	0.575
Col1a1.S	serpinh1	A0A1L8EL23	Q7ZXP6	Uncharacterized protein.	Hsp47-prov protein; Belongs to the serpin family.	0.592
Col1a1.S	sox9-a	A0A1L8EL23	I3QHH4	Uncharacterized protein.	Sex determining region Y-box 9.	0.473
Cxcr4.L	Hif-1a	A0A1L8EVR7	A0A1L8F054	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.450
Cxcr4.L	Tp53.L	A0A1L8EVR7	A0A1L8H4M6	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	P53 domain-containing protein.	0.453
Cxcr4.L	ccr2	A0A1L8EVR7	Q640C1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	LOC494705 protein; Belongs to the G-protein coupled receptor 1 family.	0.750
Cxcr4.L	cxcr4	A0A1L8EVR7	A0A1L8ENZ5	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.900
Cxcr4.L	hif1a	A0A1L8EVR7	Q6PI54	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Hif1a-prov protein.	0.554
Cxcr4.L	sox10	A0A1L8EVR7	A0A1L8GH44	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	HMG box domain-containing protein.	0.405
Cxcr4.L	sox10-2	A0A1L8EVR7	A0A1L8GNW7	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	HMG box domain-containing protein.	0.405
Cxcr4.L	sox9-a	A0A1L8EVR7	I3QHH4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Sex determining region Y-box 9.	0.410
Fus.L	Tp53.L	A0A310U9Q7	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.524