94 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	fzd2	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
	Nfatc2.S	RHD domain-containing protein. (884 aa)
	A0A1L8EM88	Uncharacterized protein. (445 aa)
	A0A1L8ENI4	Uncharacterized protein. (815 aa)
	lypd6	Uncharacterized protein. (171 aa)
	Cyct.L	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (136 aa)
	fzd5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
	crebbp	Uncharacterized protein. (2424 aa)
	Llgl1.S	WD_REPEATS_REGION domain-containing protein. (999 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	nfatc2	RHD domain-containing protein. (896 aa)
	A0A1L8EUY4	Uncharacterized protein. (818 aa)
	lypd6-2	Uncharacterized protein. (171 aa)
	cyct	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	fzd7	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
	crebbp-2	Uncharacterized protein. (2453 aa)
	A0A1L8EZU6	PID domain-containing protein. (642 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	abl1	Tyrosine-protein kinase. (1122 aa)
	NumbL	PID domain-containing protein. (588 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	mcl1	Uncharacterized protein. (277 aa)
	notch1	Uncharacterized protein. (2521 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	Smarca1.L	Uncharacterized protein. (1034 aa)
	A0A1L8F8U7	PID domain-containing protein. (588 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	numbl	PID domain-containing protein. (651 aa)
	Ripk3.S	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (425 aa)
	Mcl1.L	Uncharacterized protein. (277 aa)
	ints3	Uncharacterized protein. (1018 aa)
	prmt1	Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (351 aa)
	Bax.L	Uncharacterized protein. (221 aa)
	prmt1-2	Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (351 aa)
	axin2	Uncharacterized protein. (707 aa)
	Ngfr.S	Uncharacterized protein. (388 aa)
	cycs	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	egfr	Receptor protein-tyrosine kinase. (1208 aa)
	ripk1	Uncharacterized protein. (666 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	fzd1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
	A0A1L8FW52	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	ezh2	Uncharacterized protein. (748 aa)
	egfr-2	Receptor protein-tyrosine kinase. (1210 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1206 aa)
	Jag1.L	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
	ppp3r1	Uncharacterized protein. (170 aa)
	irf2bp2	IRF-2BP1_2 domain-containing protein. (537 aa)
	ryk	Uncharacterized protein. (596 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
	ep300	Uncharacterized protein. (2495 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	nfatc3	RHD domain-containing protein. (885 aa)
	mlkl	Protein kinase domain-containing protein. (496 aa)
	ep300-2	Uncharacterized protein. (2492 aa)
	Rho.L	Rhodopsin. (459 aa)
	etf1	eRF1_1 domain-containing protein. (437 aa)
	arid2	Uncharacterized protein. (1809 aa)
	wif1	Uncharacterized protein. (374 aa)
	arid2-2	Uncharacterized protein. (1812 aa)
	ido1	Uncharacterized protein. (398 aa)
	bcl9	BCL9 domain-containing protein. (1473 aa)
	Casp1.S	Uncharacterized protein; Belongs to the peptidase C14A family. (382 aa)
	rnf43	RING-type domain-containing protein. (664 aa)
	tfeb	BHLH domain-containing protein. (435 aa)
	il10	Uncharacterized protein. (172 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	Bcl9.L	BCL9 domain-containing protein. (1387 aa)
	casp1	Uncharacterized protein; Belongs to the peptidase C14A family. (386 aa)
	il10-2	Uncharacterized protein. (170 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (830 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	casp3.2	Uncharacterized protein; Belongs to the peptidase C14A family. (288 aa)
	isyna1	Inos-1-P_synth domain-containing protein. (563 aa)
	Prmt5.S	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (633 aa)
	Znrf3.S	RING-type domain-containing protein. (848 aa)
	Casp3.L	Uncharacterized protein; Belongs to the peptidase C14A family. (253 aa)
	Tcf3.L	BHLH domain-containing protein. (709 aa)
	isyna1-2	Inos-1-P_synth domain-containing protein. (563 aa)
	znrf3	RING-type domain-containing protein. (854 aa)
	wnt6-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	rspo2	R-spondin 2. (243 aa)
	nf-at	Nuclear factor of activated T-cell. (884 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
	prmt5	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (633 aa)
	rac1	MGC114731 protein. (192 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	axin2-2	MGC81576 protein. (707 aa)
	ppp3r1-2	Protein phospatase 3 regulatory subunit B alpha isoform type 1. (170 aa)
	nup62	Nuclear pore complex glycoprotein p62. (547 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EM88	A0A1L8FW52	A0A1L8EM88	A0A1L8FW52	Uncharacterized protein.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.537
A0A1L8EM88	Bax.L	A0A1L8EM88	A0A1L8FH04	Uncharacterized protein.	Uncharacterized protein.	0.551
A0A1L8EM88	Casp3.L	A0A1L8EM88	A0A1L8HU08	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.625
A0A1L8EM88	Cyct.L	A0A1L8EM88	A0A1L8EP92	Uncharacterized protein.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.537
A0A1L8EM88	Mcl1.L	A0A1L8EM88	A0A1L8FBT2	Uncharacterized protein.	Uncharacterized protein.	0.750
A0A1L8EM88	casp3.2	A0A1L8EM88	A0A1L8HLJ6	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.625
A0A1L8EM88	cycs	A0A1L8EM88	A0A1L8FR74	Uncharacterized protein.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.528
A0A1L8EM88	cyct	A0A1L8EM88	A0A1L8EWA6	Uncharacterized protein.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.537
A0A1L8EM88	egfr	A0A1L8EM88	A0A1L8FRS8	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.412
A0A1L8EM88	egfr-2	A0A1L8EM88	A0A1L8FWP8	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.412
A0A1L8EM88	mcl1	A0A1L8EM88	A0A1L8F4J2	Uncharacterized protein.	Uncharacterized protein.	0.750
A0A1L8EM88	tfeb	A0A1L8EM88	A0A1L8H6Y2	Uncharacterized protein.	BHLH domain-containing protein.	0.695
A0A1L8ENI4	Bcl9.L	A0A1L8ENI4	A0A1L8HC43	Uncharacterized protein.	BCL9 domain-containing protein.	0.561
A0A1L8ENI4	Fzd4.S	A0A1L8ENI4	A0A1L8HB90	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.665
A0A1L8ENI4	Jag1.L	A0A1L8ENI4	A0A1L8G723	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.440
A0A1L8ENI4	Lrp5.L	A0A1L8ENI4	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.928
A0A1L8ENI4	Notch1.S	A0A1L8ENI4	A0A1L8F124	Uncharacterized protein.	Uncharacterized protein.	0.558
A0A1L8ENI4	Wnt1.L	A0A1L8ENI4	A0A1L8HHR8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.872
A0A1L8ENI4	Znrf3.S	A0A1L8ENI4	A0A1L8HQY2	Uncharacterized protein.	RING-type domain-containing protein.	0.623
A0A1L8ENI4	bcl9	A0A1L8ENI4	A0A1L8H5D8	Uncharacterized protein.	BCL9 domain-containing protein.	0.561