STRINGSTRING
fzd10 fzd10 A0A1L8HPW4 A0A1L8HPW4 dkk2 dkk2 lef1 lef1 wnt11 wnt11 mmp13l mmp13l Mmp3.L Mmp3.L hdac7-2 hdac7-2 wnt10b wnt10b Wnt1.L Wnt1.L Tnfsf11.L Tnfsf11.L hdac1 hdac1 fzd9-2 fzd9-2 Mmp13l.S Mmp13l.S Mmp13.S Mmp13.S Sp7.S Sp7.S hdac7 hdac7 wnt1 wnt1 tnfsf11 tnfsf11 rnf43 rnf43 fzd9 fzd9 A0A1L8H5Q6 A0A1L8H5Q6 wnt16-2 wnt16-2 wif1 wif1 Hdac3.S Hdac3.S wnt16 wnt16 Prkcd.S Prkcd.S Jun.L Jun.L Wls.L Wls.L Prkacb.S Prkacb.S Lrp5.L Lrp5.L lgr4 lgr4 prkacb prkacb wls wls Dkk3.S Dkk3.S Lgr4.S Lgr4.S Runx2.L Runx2.L A0A1L8G8Y0 A0A1L8G8Y0 rspo3 rspo3 A0A1L8G5J6 A0A1L8G5J6 A0A1L8G2V6 A0A1L8G2V6 Esr1.S Esr1.S nfatc1-2 nfatc1-2 sfrp4 sfrp4 fzd1 fzd1 Fzd8.L Fzd8.L wnt3a wnt3a nfatc1 nfatc1 wnt4-2 wnt4-2 dkk1 dkk1 wnt4 wnt4 A0A1L8FG40 A0A1L8FG40 Sfrp5.S Sfrp5.S A0A1L8FBV9 A0A1L8FBV9 A0A1L8FBU8 A0A1L8FBU8 tgfb1-2 tgfb1-2 wnt11b wnt11b A0A1L8F4F9 A0A1L8F4F9 tgfb1 tgfb1 Itgav.L Itgav.L Hdac4.L Hdac4.L wnt6 wnt6 hdac5 hdac5 Axin1.S Axin1.S hdac4 hdac4 wnt10a wnt10a Hdac5.S Hdac5.S A0A1L8FLY9 A0A1L8FLY9 c-Jun c-Jun dkk2-2 dkk2-2 lef1-2 lef1-2 prkaca prkaca sfrp5 sfrp5 creb1 creb1 hdac1-2 hdac1-2 actl6a actl6a sfrp2-2 sfrp2-2 esr1 esr1 Xporc-d Xporc-d fos-2 fos-2 ctnnb1 ctnnb1 ewsr1 ewsr1 src src dkk1-2 dkk1-2 wnt7b wnt7b xfz8 xfz8 wnt10a-2 wnt10a-2 nf-at nf-at rspo2 rspo2 wif1-2 wif1-2 wnt6-2 wnt6-2 fos fos ctsk ctsk mef2c-2 mef2c-2 znrf3 znrf3 lif lif sfrp2 sfrp2 mef2c mef2c Znrf3.S Znrf3.S
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fzd10Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
A0A1L8HPW4Uncharacterized protein. (216 aa)
dkk2Dickkopf_N domain-containing protein. (255 aa)
lef1HMG box domain-containing protein. (372 aa)
wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
mmp13lZnMc domain-containing protein. (472 aa)
Mmp3.LZnMc domain-containing protein. (503 aa)
hdac7-2Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (957 aa)
wnt10bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
Wnt1.LProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
Tnfsf11.LTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (290 aa)
hdac1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
fzd9-2Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (587 aa)
Mmp13l.SZnMc domain-containing protein. (472 aa)
Mmp13.SZnMc domain-containing protein. (258 aa)
Sp7.SUncharacterized protein. (409 aa)
hdac7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (972 aa)
wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
tnfsf11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (290 aa)
rnf43RING-type domain-containing protein. (664 aa)
fzd9Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (587 aa)
A0A1L8H5Q6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
wnt16-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
wif1Uncharacterized protein. (374 aa)
Hdac3.SHistone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (405 aa)
wnt16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
Prkcd.SProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (806 aa)
Jun.LBZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
Wls.LUncharacterized protein. (541 aa)
Prkacb.SUncharacterized protein; Belongs to the protein kinase superfamily. (338 aa)
Lrp5.LUncharacterized protein. (1517 aa)
lgr4G_PROTEIN_RECEP_F1_2 domain-containing protein. (953 aa)
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (396 aa)
wlsUncharacterized protein. (541 aa)
Dkk3.SDickkopf_N domain-containing protein. (257 aa)
Lgr4.SG_PROTEIN_RECEP_F1_2 domain-containing protein. (956 aa)
Runx2.LRunt-related transcription factor. (455 aa)
A0A1L8G8Y0Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
rspo3Uncharacterized protein. (253 aa)
A0A1L8G5J6Runt-related transcription factor. (451 aa)
A0A1L8G2V6Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (467 aa)
Esr1.SEstrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
nfatc1-2RHD domain-containing protein. (933 aa)
sfrp4Uncharacterized protein. (353 aa)
fzd1Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
Fzd8.LUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
nfatc1RHD domain-containing protein. (955 aa)
wnt4-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
dkk1Dickkopf_N domain-containing protein. (263 aa)
wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
A0A1L8FG40Uncharacterized protein. (2091 aa)
Sfrp5.SUncharacterized protein. (315 aa)
A0A1L8FBV9Uncharacterized protein; Belongs to the peptidase C1 family. (331 aa)
A0A1L8FBU8Uncharacterized protein; Belongs to the peptidase C1 family. (331 aa)
tgfb1-2Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
wnt11bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
A0A1L8F4F9Uncharacterized protein; Belongs to the peptidase C1 family. (329 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
Itgav.LIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1080 aa)
Hdac4.LHistone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1171 aa)
wnt6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1016 aa)
Axin1.SUncharacterized protein. (839 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
wnt10aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
Hdac5.SHistone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1048 aa)
A0A1L8FLY9Uncharacterized protein. (1971 aa)
c-JunC-Jun protein; Belongs to the bZIP family. (312 aa)
dkk2-2Dickkopf homolog 2. (255 aa)
lef1-2Lymphoid enhancer factor XLEF-1. (372 aa)
prkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
sfrp5Secreted frizzled-related protein 5. (315 aa)
creb1Creb1-prov protein. (324 aa)
hdac1-2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
actl6aBaf53a-pending-prov protein; Belongs to the actin family. (429 aa)
sfrp2-2Sfrp2-prov protein. (298 aa)
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
Xporc-dXporc-d protein; Belongs to the membrane-bound acyltransferase family. (450 aa)
fos-2MGC80305 protein. (368 aa)
ctnnb1Beta-catenin protein. (781 aa)
ewsr1Uncharacterized protein. (671 aa)
srcTyrosine-protein kinase. (532 aa)
dkk1-2Dickkopf homolog 1. (259 aa)
wnt7bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
xfz8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
wnt10a-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
nf-atNuclear factor of activated T-cell. (884 aa)
rspo2R-spondin 2. (243 aa)
wif1-2Wnt inhibitory factor-1. (374 aa)
wnt6-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
fosBZIP domain-containing protein. (369 aa)
ctskLOC100127265 protein; Belongs to the peptidase C1 family. (331 aa)
mef2c-2MADS-box domain-containing protein. (464 aa)
znrf3RING-type domain-containing protein. (854 aa)
lifUncharacterized protein. (216 aa)
sfrp2Uncharacterized protein. (295 aa)
mef2cMADS-box domain-containing protein. (464 aa)
Znrf3.SRING-type domain-containing protein. (848 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
Server load: low (22%) [HD]