21 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	topbp1	Uncharacterized protein. (1573 aa)
	dbf4	Uncharacterized protein. (661 aa)
	mcm4	DNA helicase; Belongs to the MCM family. (858 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	Wdhd1.L	Uncharacterized protein. (1127 aa)
	Dbf4b.L	DBF4-type domain-containing protein. (784 aa)
	Cdc6.L	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (645 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	Clspn.S	Claspin. (1286 aa)
	LOC100189571	Uncharacterized protein. (608 aa)
	cdc45	Uncharacterized protein. (567 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	Alb.S	Uncharacterized protein. (607 aa)
	Mrc1.L	C-type lectin domain-containing protein. (220 aa)
	mcm10	Mcm10 domain-containing protein. (860 aa)
	pxdn-2	Uncharacterized protein. (1464 aa)
	Atr.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa)
	pxdn	Uncharacterized protein. (1461 aa)
	Mcm4.S	DNA helicase; Belongs to the MCM family. (863 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Alb.S	pxdn	A0A1L8HMG9	A0A1L8G530	Uncharacterized protein.	Uncharacterized protein.	0.936
Alb.S	pxdn-2	A0A1L8HMG9	A0A1L8GBD8	Uncharacterized protein.	Uncharacterized protein.	0.936
Atr.L	Cdc6.L	A0A1L8GAP7	A0A1L8ES00	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.925
Atr.L	Chek2.L	A0A1L8GAP7	A0A1L8I0A0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.999
Atr.L	Clspn.S	A0A1L8GAP7	F8WKR8	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Claspin.	0.955
Atr.L	Dbf4b.L	A0A1L8GAP7	A0A1L8ESD2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	DBF4-type domain-containing protein.	0.960
Atr.L	Mcm4.S	A0A1L8GAP7	A0A1L8FYX1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	DNA helicase; Belongs to the MCM family.	0.893
Atr.L	Mrc1.L	A0A1L8GAP7	A0A1L8H4B7	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	C-type lectin domain-containing protein.	0.778
Atr.L	Wdhd1.L	A0A1L8GAP7	A0A1L8F9Z9	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.931
Atr.L	cdc45	A0A1L8GAP7	A0A1L8I0M4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.960
Atr.L	chek1	A0A1L8GAP7	A0A1L8FFS1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.999
Atr.L	chek1-2	A0A1L8GAP7	A0A1L8FL95	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Protein kinase domain-containing protein.	0.999
Atr.L	dbf4	A0A1L8GAP7	A0A1L8FVR6	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.975
Atr.L	mcm10	A0A1L8GAP7	A0A1L8GZD7	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Mcm10 domain-containing protein.	0.910
Atr.L	mcm4	A0A1L8GAP7	A0A1L8FSY2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	DNA helicase; Belongs to the MCM family.	0.893
Atr.L	pcna	A0A1L8GAP7	Q9I893	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.743
Atr.L	rad9a	A0A1L8GAP7	Q7ZZU5	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.998
Atr.L	topbp1	A0A1L8GAP7	A0A1L8FWJ6	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.999
Cdc6.L	Atr.L	A0A1L8ES00	A0A1L8GAP7	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.925
Cdc6.L	Chek2.L	A0A1L8ES00	A0A1L8I0A0	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Uncharacterized protein.	0.833