(92 nodes) (2020) Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration. network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Sod2.S	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (226 aa)
	SPAST	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (600 aa)
	psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (449 aa)
	pomc	Uncharacterized protein. (260 aa)
	rtn4-2	Reticulon. (1024 aa)
	Mapre3.S	Uncharacterized protein. (316 aa)
	rab3gap2	Uncharacterized protein. (1390 aa)
	spast	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (595 aa)
	A0A1L8G7M0	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (445 aa)
	A0A1L8G820	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
	awat1	Uncharacterized protein. (338 aa)
	Pomc.L	Uncharacterized protein. (282 aa)
	A0A1L8GCW8	Uncharacterized protein. (364 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	RTN3	Reticulon. (214 aa)
	Itpr1.S	Uncharacterized protein. (2693 aa)
	bscl2	Uncharacterized protein. (341 aa)
	Rtn3.L	Reticulon. (206 aa)
	Sec22b.S	Uncharacterized protein; Belongs to the synaptobrevin family. (221 aa)
	Hspa9.L	Uncharacterized protein; Belongs to the heat shock protein 70 family. (665 aa)
	lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	ccpg1	Uncharacterized protein. (872 aa)
	mctp2	Uncharacterized protein. (869 aa)
	Mogat3.L	Uncharacterized protein. (422 aa)
	orai1	Uncharacterized protein. (257 aa)
	nck2	Cytoplasmic protein. (381 aa)
	dgat2	Uncharacterized protein. (361 aa)
	inpp5k	IPPc domain-containing protein. (476 aa)
	nck2-2	Cytoplasmic protein. (381 aa)
	dgat2-2	Uncharacterized protein. (361 aa)
	stx18	Syntaxin-18_N domain-containing protein. (343 aa)
	A0A1L8HMD5	Alpha-synuclein; Belongs to the synuclein family. (212 aa)
	jph4	Uncharacterized protein. (586 aa)
	orai2	Uncharacterized protein. (258 aa)
	reep1	Receptor expression-enhancing protein. (224 aa)
	A0A1L8HTA9	Uncharacterized protein. (3120 aa)
	stx18-2	Syntaxin-18_N domain-containing protein. (392 aa)
	Vps13a.L	Uncharacterized protein. (3184 aa)
	jph4-2	Uncharacterized protein. (582 aa)
	Sec62.S	Uncharacterized protein. (404 aa)
	LOC496290	LOC496290 protein. (461 aa)
	LOC100127341	LOC100127341 protein. (321 aa)
	rint1	LOC100174798 protein. (785 aa)
	ins-2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	nck1	Cytoplasmic protein. (377 aa)
	nck1-2	Cytoplasmic protein. (377 aa)
	lep-2	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	rabif	MGC115104 protein. (118 aa)
	pmp22	Pmp22-prov protein. (159 aa)
	rab18-2	RAB18 protein. (206 aa)
	mfn2-2	MGC81251 protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (756 aa)
	rab10	MGC68629 protein. (200 aa)
	snca	Alpha-synuclein; Belongs to the synuclein family. (141 aa)
	hspa9	MGC52616 protein; Belongs to the heat shock protein 70 family. (670 aa)
	sec61b	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
	klf9	Basic transcription element binding protein 1. (292 aa)
	tbc1d20.1-2	MGC52691 protein. (412 aa)
	tbc1d20.1	Rab-GAP TBC domain-containing protein. (387 aa)
	gdap1l1	Uncharacterized protein. (364 aa)
	Vapb.L	MSP domain-containing protein. (289 aa)
	gdap1l1-2	Uncharacterized protein. (364 aa)
	Pmp22.L	Uncharacterized protein. (159 aa)
	A0A1L8EZW3	Uncharacterized protein. (777 aa)
	A0A1L8EZY9	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
	Rtn1.S	Reticulon. (752 aa)
	rtn2	Reticulon. (322 aa)
	dgat2l6	Uncharacterized protein. (361 aa)
	rtn2-2	Reticulon. (321 aa)
	A0A1L8FAD2	Uncharacterized protein. (1361 aa)
	Rtn1.L	Reticulon. (768 aa)
	psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
	pdzd8	Uncharacterized protein. (1074 aa)
	gabarapl1	Uncharacterized protein. (117 aa)
	A0A1L8FEX2	FYVE-type domain-containing protein. (355 aa)
	A0A1L8FFB1	Uncharacterized protein. (409 aa)
	mfn2	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (756 aa)
	bace1	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (503 aa)
	Zw10.S	Uncharacterized protein. (776 aa)
	A0A1L8FJG2	FYVE-type domain-containing protein. (423 aa)
	tardbp	Uncharacterized protein. (413 aa)
	bace1-2	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (503 aa)
	Zw10.L	Uncharacterized protein. (776 aa)
	vps13d	Uncharacterized protein. (4359 aa)
	A0A1L8FND1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	egfr	Receptor protein-tyrosine kinase. (1208 aa)
	Acbd5.L	Acyl-CoA-binding domain-containing protein 5; Binds medium- and long-chain acyl-CoA esters. (464 aa)
	rab18	Uncharacterized protein. (205 aa)
	egfr-2	Receptor protein-tyrosine kinase. (1210 aa)
	Vapa.L	MSP domain-containing protein. (236 aa)
	gdap1	Uncharacterized protein; Belongs to the GST superfamily. (347 aa)
	Tbc1d20.2.L	Rab-GAP TBC domain-containing protein. (388 aa)
	rtn4	Reticulon. (1043 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EZW3	RTN3	A0A1L8EZW3	A0A1L8GD96	Uncharacterized protein.	Reticulon.	0.632
A0A1L8EZW3	Rtn1.L	A0A1L8EZW3	A0A1L8FAE3	Uncharacterized protein.	Reticulon.	0.633
A0A1L8EZW3	Rtn1.S	A0A1L8EZW3	A0A1L8F043	Uncharacterized protein.	Reticulon.	0.633
A0A1L8EZW3	Rtn3.L	A0A1L8EZW3	A0A1L8GJY0	Uncharacterized protein.	Reticulon.	0.629
A0A1L8EZW3	SPAST	A0A1L8EZW3	A0A1L8G226	Uncharacterized protein.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.688
A0A1L8EZW3	Vapa.L	A0A1L8EZW3	A0A1L8FYJ2	Uncharacterized protein.	MSP domain-containing protein.	0.457
A0A1L8EZW3	Vapb.L	A0A1L8EZW3	A0A1L8ELN1	Uncharacterized protein.	MSP domain-containing protein.	0.541
A0A1L8EZW3	pdzd8	A0A1L8EZW3	A0A1L8FDT8	Uncharacterized protein.	Uncharacterized protein.	0.582
A0A1L8EZW3	rab10	A0A1L8EZW3	Q6PAW9	Uncharacterized protein.	MGC68629 protein.	0.558
A0A1L8EZW3	rab18	A0A1L8EZW3	A0A1L8FVI0	Uncharacterized protein.	Uncharacterized protein.	0.491
A0A1L8EZW3	rab18-2	A0A1L8EZW3	Q6GM52	Uncharacterized protein.	RAB18 protein.	0.491
A0A1L8EZW3	reep1	A0A1L8EZW3	A0A1L8HT57	Uncharacterized protein.	Receptor expression-enhancing protein.	0.749
A0A1L8EZW3	rtn2	A0A1L8EZW3	A0A1L8F3E9	Uncharacterized protein.	Reticulon.	0.548
A0A1L8EZW3	rtn2-2	A0A1L8EZW3	A0A1L8F838	Uncharacterized protein.	Reticulon.	0.549
A0A1L8EZW3	rtn4	A0A1L8EZW3	A0A1L8G1I6	Uncharacterized protein.	Reticulon.	0.534
A0A1L8EZW3	rtn4-2	A0A1L8EZW3	A0A1L8G5R6	Uncharacterized protein.	Reticulon.	0.442
A0A1L8EZW3	sec61b	A0A1L8EZW3	Q8AVT7	Uncharacterized protein.	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	0.578
A0A1L8EZW3	spast	A0A1L8EZW3	A0A1L8G7L7	Uncharacterized protein.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.688
A0A1L8EZY9	A0A1L8G7M0	A0A1L8EZY9	A0A1L8G7M0	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.977
A0A1L8EZY9	A0A1L8HMD5	A0A1L8EZY9	A0A1L8HMD5	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Alpha-synuclein; Belongs to the synuclein family.	0.586