26 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fgfr2-2	Fibroblast growth factor receptor. (832 aa)
	grb2	Uncharacterized protein. (229 aa)
	grb2-2	Uncharacterized protein. (229 aa)
	fgfr2	Fibroblast growth factor receptor. (830 aa)
	cda	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (160 aa)
	cda-2	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (156 aa)
	egfr	Receptor protein-tyrosine kinase. (1208 aa)
	egfr-2	Receptor protein-tyrosine kinase. (1210 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	plek	Uncharacterized protein. (350 aa)
	Irs1.S	Uncharacterized protein. (1227 aa)
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	Rho.L	Rhodopsin. (459 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
	egr1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (497 aa)
	frs2	IRS-type PTB domain-containing protein. (518 aa)
	crk	Uncharacterized protein. (297 aa)
	Crk.L	Uncharacterized protein. (297 aa)
	src	Tyrosine-protein kinase. (532 aa)
	rabif	MGC115104 protein. (118 aa)
	rac1	MGC114731 protein. (192 aa)
	crkl	MGC84382 protein. (302 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	frs3	Frs3 protein. (517 aa)
	crkl-2	MGC81407 protein. (302 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Crk.L	Irs1.S	A0A1L8HDP2	A0A1L8GB03	Uncharacterized protein.	Uncharacterized protein.	0.505
Crk.L	Ptpn11.S	A0A1L8HDP2	Q92124	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.737
Crk.L	crkl	A0A1L8HDP2	Q66KG8	Uncharacterized protein.	MGC84382 protein.	0.634
Crk.L	crkl-2	A0A1L8HDP2	Q6NTZ1	Uncharacterized protein.	MGC81407 protein.	0.634
Crk.L	egfr	A0A1L8HDP2	A0A1L8FRS8	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.953
Crk.L	egfr-2	A0A1L8HDP2	A0A1L8FWP8	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.953
Crk.L	fgfr2	A0A1L8HDP2	A0A1L8FE89	Uncharacterized protein.	Fibroblast growth factor receptor.	0.538
Crk.L	fgfr2-2	A0A1L8HDP2	A0A1L8FJ12	Uncharacterized protein.	Fibroblast growth factor receptor.	0.538
Crk.L	frs2	A0A1L8HDP2	A0A1L8GYJ1	Uncharacterized protein.	IRS-type PTB domain-containing protein.	0.920
Crk.L	frs3	A0A1L8HDP2	Q6IR73	Uncharacterized protein.	Frs3 protein.	0.782
Crk.L	grb2	A0A1L8HDP2	A0A1L8EMZ6	Uncharacterized protein.	Uncharacterized protein.	0.870
Crk.L	grb2-2	A0A1L8HDP2	A0A1L8EUF2	Uncharacterized protein.	Uncharacterized protein.	0.868
Crk.L	ptpn11b	A0A1L8HDP2	Q6GP31	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.737
Crk.L	rabif	A0A1L8HDP2	Q569S2	Uncharacterized protein.	MGC115104 protein.	0.637
Crk.L	rac1	A0A1L8HDP2	Q58E25	Uncharacterized protein.	MGC114731 protein.	0.718
Crk.L	src	A0A1L8HDP2	Q2TAR1	Uncharacterized protein.	Tyrosine-protein kinase.	0.887
Irs1.S	Crk.L	A0A1L8GB03	A0A1L8HDP2	Uncharacterized protein.	Uncharacterized protein.	0.505
Irs1.S	Ptpn11.S	A0A1L8GB03	Q92124	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.737
Irs1.S	crk	A0A1L8GB03	A0A1L8H629	Uncharacterized protein.	Uncharacterized protein.	0.505
Irs1.S	egfr	A0A1L8GB03	A0A1L8FRS8	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.410