53 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	egfr	Receptor protein-tyrosine kinase. (1208 aa)
	Sox2.S	HMG box domain-containing protein. (194 aa)
	stau1	Uncharacterized protein. (707 aa)
	pard6b	Uncharacterized protein. (377 aa)
	pard6b-2	Uncharacterized protein. (376 aa)
	ocm4.10	Uncharacterized protein; Belongs to the parvalbumin family. (109 aa)
	A0A1L8EZU6	PID domain-containing protein. (642 aa)
	Syn1.S	Uncharacterized protein. (703 aa)
	NumbL	PID domain-containing protein. (588 aa)
	nes	IF rod domain-containing protein; Belongs to the intermediate filament family. (1875 aa)
	Syn1.L	Synapsin_C domain-containing protein. (480 aa)
	trim32	Uncharacterized protein. (649 aa)
	A0A1L8F8U7	PID domain-containing protein. (588 aa)
	numbl	PID domain-containing protein. (651 aa)
	nes-2	IF rod domain-containing protein; Belongs to the intermediate filament family. (1954 aa)
	cdk1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
	Cdk1.L	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (333 aa)
	A0A1L8FND1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	pard3	Uncharacterized protein. (1369 aa)
	pard3-2	Uncharacterized protein. (1332 aa)
	egfr-2	Receptor protein-tyrosine kinase. (1210 aa)
	pomc	Uncharacterized protein. (260 aa)
	Sst.2	Somatostatin domain-containing protein. (157 aa)
	Prkci.L	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (588 aa)
	Pomc.L	Uncharacterized protein. (282 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	pax6	Uncharacterized protein. (467 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (396 aa)
	pax6-2	Uncharacterized protein. (467 aa)
	Prkacb.S	Uncharacterized protein; Belongs to the protein kinase superfamily. (338 aa)
	A0A1L8GQJ6	Synapsin_C domain-containing protein. (308 aa)
	A0A1L8GR36	Uncharacterized protein. (902 aa)
	pkm	Pyruvate kinase; Belongs to the pyruvate kinase family. (527 aa)
	Gria1.L	Uncharacterized protein. (902 aa)
	lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	Pkm	Pyruvate kinase; Belongs to the pyruvate kinase family. (527 aa)
	igf1r	Tyrosine-protein kinase receptor. (1358 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	Rps6kb1.S	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
	Ranbp2.S	Uncharacterized protein. (2843 aa)
	Cdk2.S	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
	rps6kb1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (521 aa)
	ranbp2	Uncharacterized protein. (2905 aa)
	Eif4e1b.S	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (280 aa)
	ins-2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	LOC398022	Tyrosine-protein kinase receptor. (1363 aa)
	lep-2	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	eif4e	MGC85107 protein; Belongs to the eukaryotic initiation factor 4E family. (213 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (159 aa)
	sst	Preprosomatostatin 1a. (115 aa)
	prkaca	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	cdknx	Cyclin-dependent kinase inhibitor p28. (209 aa)
	pin1-2	Peptidyl-prolyl cis-trans isomerase. (159 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EZU6	Prkci.L	A0A1L8EZU6	A0A1L8GAK2	PID domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.822
A0A1L8EZU6	pard3	A0A1L8EZU6	A0A1L8FQM3	PID domain-containing protein.	Uncharacterized protein.	0.587
A0A1L8EZU6	pard3-2	A0A1L8EZU6	A0A1L8FVE8	PID domain-containing protein.	Uncharacterized protein.	0.539
A0A1L8EZU6	pard6b	A0A1L8EZU6	A0A1L8ELH2	PID domain-containing protein.	Uncharacterized protein.	0.774
A0A1L8EZU6	pard6b-2	A0A1L8EZU6	A0A1L8ESP6	PID domain-containing protein.	Uncharacterized protein.	0.774
A0A1L8F8U7	Prkci.L	A0A1L8F8U7	A0A1L8GAK2	PID domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.822
A0A1L8F8U7	egfr	A0A1L8F8U7	A0A1L8FRS8	PID domain-containing protein.	Receptor protein-tyrosine kinase.	0.400
A0A1L8F8U7	egfr-2	A0A1L8F8U7	A0A1L8FWP8	PID domain-containing protein.	Receptor protein-tyrosine kinase.	0.400
A0A1L8F8U7	pard3	A0A1L8F8U7	A0A1L8FQM3	PID domain-containing protein.	Uncharacterized protein.	0.587
A0A1L8F8U7	pard3-2	A0A1L8F8U7	A0A1L8FVE8	PID domain-containing protein.	Uncharacterized protein.	0.539
A0A1L8F8U7	pard6b	A0A1L8F8U7	A0A1L8ELH2	PID domain-containing protein.	Uncharacterized protein.	0.774
A0A1L8F8U7	pard6b-2	A0A1L8F8U7	A0A1L8ESP6	PID domain-containing protein.	Uncharacterized protein.	0.774
A0A1L8FND1	A0A1L8H5Q6	A0A1L8FND1	A0A1L8H5Q6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.524
A0A1L8FND1	Eif4e1b.S	A0A1L8FND1	A0A1L8HM93	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.408
A0A1L8FND1	LOC398022	A0A1L8FND1	B7ZSL0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.994
A0A1L8FND1	Pomc.L	A0A1L8FND1	A0A1L8GC94	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.770
A0A1L8FND1	Prkacb.S	A0A1L8FND1	A0A1L8GLU4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.724
A0A1L8FND1	Rps6kb1.S	A0A1L8FND1	A0A1L8H7Z6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.679
A0A1L8FND1	Sox2.S	A0A1L8FND1	A0A1L8EK54	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	HMG box domain-containing protein.	0.537
A0A1L8FND1	Sst.2	A0A1L8FND1	A0A1L8G9W6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Somatostatin domain-containing protein.	0.954