89 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fzd6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (724 aa)
	dgat1	O-acyltransferase. (472 aa)
	rac3	RAC1 protein. (192 aa)
	c-Jun	C-Jun protein; Belongs to the bZIP family. (312 aa)
	rala	Ras related small G protein RAL-A. (206 aa)
	dkk2-2	Dickkopf homolog 2. (255 aa)
	kras-3	LOC397771 protein. (186 aa)
	hras	Small G-protein H-Ras. (189 aa)
	creb1	Creb1-prov protein. (324 aa)
	ror2-2	Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	sfrp2-2	Sfrp2-prov protein. (298 aa)
	rhoa	MGC64296 protein. (193 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	soat1-2	O-acyltransferase. (550 aa)
	kras-2	Uncharacterized protein. (187 aa)
	axin2-2	MGC81576 protein. (707 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	krasl	Uncharacterized protein. (187 aa)
	rac1	MGC114731 protein. (192 aa)
	adam17-2	Disintegrin metalloproteinase. (839 aa)
	sfrpx	LOC100125663 protein. (288 aa)
	cdh11-2	Cadherin; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	xfz8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	wnt10a-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	wnt6-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	znrf3	RING-type domain-containing protein. (854 aa)
	sfrp2	Uncharacterized protein. (295 aa)
	Casp3.L	Uncharacterized protein; Belongs to the peptidase C14A family. (253 aa)
	Znrf3.S	RING-type domain-containing protein. (848 aa)
	ror2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	tnks	Poly [ADP-ribose] polymerase. (1298 aa)
	dkk2	Dickkopf_N domain-containing protein. (255 aa)
	casp3.2	Uncharacterized protein; Belongs to the peptidase C14A family. (288 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	A0A1L8HJN4	Uncharacterized protein. (291 aa)
	Yap1.L	Uncharacterized protein. (459 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	Soat2.S	O-acyltransferase. (532 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	rnf43	RING-type domain-containing protein. (664 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	Sfrp1.L	Uncharacterized protein. (311 aa)
	Lgr5.L	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	lgr5	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	sfrp1	Uncharacterized protein. (311 aa)
	A0A1L8GQT6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	Rho.L	Rhodopsin. (459 aa)
	soat1	O-acyltransferase. (553 aa)
	Jun.L	BZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
	Wls.L	Uncharacterized protein. (541 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	lgr4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (953 aa)
	wls	Uncharacterized protein. (541 aa)
	Lgr4.S	G_PROTEIN_RECEP_F1_2 domain-containing protein. (956 aa)
	ryk	Uncharacterized protein. (596 aa)
	adam17	Uncharacterized protein. (855 aa)
	fzd2	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
	ralb	Uncharacterized protein. (206 aa)
	A0A1L8ENI4	Uncharacterized protein. (815 aa)
	wnt10a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	Frzb.S	Uncharacterized protein. (319 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	stat3.1	Signal transducer and activator of transcription. (769 aa)
	Sdc4.L	Syndecan domain-containing protein. (205 aa)
	A0A1L8EUY4	Uncharacterized protein. (818 aa)
	ralb-2	Uncharacterized protein. (206 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	Frzb-1	Uncharacterized protein. (319 aa)
	fzd7	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
	daam1	Uncharacterized protein. (1077 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	taz	Tafazzin family protein; Belongs to the taffazin family. (262 aa)
	notch1	Uncharacterized protein. (2521 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	tnks2	Poly [ADP-ribose] polymerase. (1165 aa)
	kras	Uncharacterized protein. (186 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	axin2	Uncharacterized protein. (707 aa)
	A0A1L8FQM6	CYCLIN domain-containing protein; Belongs to the cyclin family. (341 aa)
	cdk14	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (466 aa)
	Fzd6.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
	Myc.S	Myc_N domain-containing protein. (176 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Fzd8.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	fzd1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
	cdk14-2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (469 aa)
	sfrp4	Uncharacterized protein. (353 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENI4	A0A1L8GQT6	A0A1L8ENI4	A0A1L8GQT6	Uncharacterized protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.849
A0A1L8ENI4	Frzb-1	A0A1L8ENI4	A0A1L8EWF4	Uncharacterized protein.	Uncharacterized protein.	0.459
A0A1L8ENI4	Frzb.S	A0A1L8ENI4	A0A1L8EPI8	Uncharacterized protein.	Uncharacterized protein.	0.459
A0A1L8ENI4	Fzd6.S	A0A1L8ENI4	A0A1L8FTP5	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.566
A0A1L8ENI4	Fzd8.L	A0A1L8ENI4	A0A1L8FVD0	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.635
A0A1L8ENI4	Jun.L	A0A1L8ENI4	A0A1L8GLZ4	Uncharacterized protein.	BZIP domain-containing protein; Belongs to the bZIP family.	0.535
A0A1L8ENI4	Lgr4.S	A0A1L8ENI4	A0A1L8GDQ5	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.599
A0A1L8ENI4	Lgr5.L	A0A1L8ENI4	A0A1L8GYN0	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.817
A0A1L8ENI4	Lrp5.L	A0A1L8ENI4	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.928
A0A1L8ENI4	Myc.S	A0A1L8ENI4	A0A1L8FTW7	Uncharacterized protein.	Myc_N domain-containing protein.	0.692
A0A1L8ENI4	Notch1.S	A0A1L8ENI4	A0A1L8F124	Uncharacterized protein.	Uncharacterized protein.	0.558
A0A1L8ENI4	Sfrp1.L	A0A1L8ENI4	A0A1L8H1S5	Uncharacterized protein.	Uncharacterized protein.	0.753
A0A1L8ENI4	Tp53.L	A0A1L8ENI4	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.591
A0A1L8ENI4	Wls.L	A0A1L8ENI4	A0A1L8GLU8	Uncharacterized protein.	Uncharacterized protein.	0.674
A0A1L8ENI4	Wnt1.L	A0A1L8ENI4	A0A1L8HHR8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.872
A0A1L8ENI4	Znrf3.S	A0A1L8ENI4	A0A1L8HQY2	Uncharacterized protein.	RING-type domain-containing protein.	0.623
A0A1L8ENI4	actl6a	A0A1L8ENI4	Q7ZYI5	Uncharacterized protein.	Baf53a-pending-prov protein; Belongs to the actin family.	0.429
A0A1L8ENI4	c-Jun	A0A1L8ENI4	Q9PVZ1	Uncharacterized protein.	C-Jun protein; Belongs to the bZIP family.	0.535
A0A1L8ENI4	ctnnb1	A0A1L8ENI4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.998
A0A1L8ENI4	daam1	A0A1L8ENI4	A0A1L8EZW6	Uncharacterized protein.	Uncharacterized protein.	0.420