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| | parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa) |
| | top2a | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1579 aa) |
| | psmd14 | Psmd14-prov protein. (310 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | sumo2 | Small ubiquitin-related modifier. (95 aa) |
| | Sumo1.S | Ubiquitin-like domain-containing protein. (141 aa) |
| | rtel1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1275 aa) |
| | Brca1.L | Uncharacterized protein. (1582 aa) |
| | top1.1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (821 aa) |
| | sumo2-2 | Ubiquitin-like domain-containing protein. (98 aa) |
| | Sumo1.L | Ubiquitin-like domain-containing protein. (148 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1022 aa) |
| | Cul4b.S | CULLIN_2 domain-containing protein; Belongs to the cullin family. (866 aa) |
| | Ring1.S | RING-type domain-containing protein. (376 aa) |
| | A0A1L8F712 | Serine protease; Belongs to the peptidase S1B family. (349 aa) |
| | ring1 | RING-type domain-containing protein. (372 aa) |
| | mdc1 | Uncharacterized protein. (2103 aa) |
| | sae1 | ThiF domain-containing protein. (344 aa) |
| | Tdp1.L | Uncharacterized protein. (597 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa) |
| | chek1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa) |
| | pnkp | FHA_2 domain-containing protein. (594 aa) |
| | ercc1 | Uncharacterized protein. (297 aa) |
| | chek1-2 | Protein kinase domain-containing protein. (510 aa) |
| | cbl | Uncharacterized protein. (887 aa) |
| | lig1 | DNA ligase. (1062 aa) |
| | Pold1.L | DNA polymerase. (1109 aa) |
| | Ddi2.L | Ubiquitin-like domain-containing protein. (393 aa) |
| | Bmi1.S | RING-type domain-containing protein. (367 aa) |
| | Tdp2.S | Endo/exonuclease/phosphatase domain-containing protein. (382 aa) |
| | Bmi1.L | RING-type domain-containing protein. (323 aa) |
| | Prkdc.L | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (4146 aa) |
| | Nbn.L | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa) |
| | Znf451.L | Uncharacterized protein. (1207 aa) |
| | cul3 | CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa) |
| | cul3-2 | CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa) |
| | Cdh1.S | Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (914 aa) |
| | top1.2 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (770 aa) |
| | rbx1 | RING-type domain-containing protein. (120 aa) |
| | Mst1.S | Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (716 aa) |
| | fen1-2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa) |
| | cdh1 | Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa) |
| | cdh3 | Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa) |
| | uba2 | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (641 aa) |
| | mst1 | Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (718 aa) |
| | polb | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (334 aa) |
| | pias1 | Uncharacterized protein. (640 aa) |
| | rad50 | Zinc-hook domain-containing protein. (1311 aa) |
| | rad50-2 | Zinc-hook domain-containing protein. (1312 aa) |
| | Pias1.L | Uncharacterized protein. (649 aa) |
| | rpa2 | RPA_C domain-containing protein. (274 aa) |
| | rpa2-2 | RPA_C domain-containing protein. (276 aa) |
| | brca2 | Tower domain-containing protein. (3177 aa) |
| | acin1 | Uncharacterized protein. (2021 aa) |
| | Rnf4-a | RING-type domain-containing protein. (190 aa) |
| | Pias4.L | Uncharacterized protein. (544 aa) |
| | Chek2.L | Uncharacterized protein. (392 aa) |
| | Top3b.L | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (824 aa) |
| | Cbl.S | Uncharacterized protein. (945 aa) |
| | rnf4 | LOC495944 protein. (190 aa) |
