50 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nfatc1	RHD domain-containing protein. (955 aa)
	Pold1.L	DNA polymerase. (1109 aa)
	cbl	Uncharacterized protein. (887 aa)
	btk	Tyrosine-protein kinase. (648 aa)
	stat3.1	Signal transducer and activator of transcription. (769 aa)
	pxn-2	LOC397826 protein; Belongs to the paxillin family. (539 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	cxcr1	CXCR2 like protein; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	got1	Aspartate aminotransferase. (411 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	zap70	Tyrosine-protein kinase. (617 aa)
	fos-2	MGC80305 protein. (368 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	src	Tyrosine-protein kinase. (532 aa)
	smad7-2	Mothers against decapentaplegic homolog. (382 aa)
	il1b-A	Interleukin-1; Belongs to the IL-1 family. (283 aa)
	itgb3	Integrin beta; Belongs to the integrin beta chain family. (788 aa)
	tyrobp	ITAM-bearing signaling subunit. (104 aa)
	fos	BZIP domain-containing protein. (369 aa)
	Fus.L	Uncharacterized protein. (511 aa)
	pxn	Uncharacterized protein; Belongs to the paxillin family. (542 aa)
	jak2	Tyrosine-protein kinase. (1129 aa)
	Kit.L	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
	smad7	Mothers against decapentaplegic homolog. (382 aa)
	Kit.S	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (963 aa)
	Tnfsf11.L	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (290 aa)
	il10-2	Uncharacterized protein. (170 aa)
	tnfsf11	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (290 aa)
	il10	Uncharacterized protein. (172 aa)
	cd86	Uncharacterized protein. (321 aa)
	Il1b.L	Interleukin-1. (145 aa)
	hgf-2	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
	cd36-2	Uncharacterized protein; Belongs to the CD36 family. (468 aa)
	egr1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (497 aa)
	hgf	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
	cd36	Uncharacterized protein; Belongs to the CD36 family. (476 aa)
	Got2.L	Aspartate aminotransferase. (427 aa)
	IL-34	Uncharacterized protein. (235 aa)
	A0A1L8GLA9	Aminotran_1_2 domain-containing protein. (536 aa)
	got2	Aspartate aminotransferase. (427 aa)
	A0A1L8GFB1	Aminotran_1_2 domain-containing protein. (520 aa)
	il34	Uncharacterized protein. (202 aa)
	Pomc.L	Uncharacterized protein. (282 aa)
	sdc1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (607 aa)
	Rel.L	RHD domain-containing protein. (583 aa)
	pomc	Uncharacterized protein. (260 aa)
	A0A1L8G525	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (704 aa)
	Gpt2.L	Aminotran_1_2 domain-containing protein. (540 aa)
	nfatc1-2	RHD domain-containing protein. (933 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8G525	IL-34	A0A1L8G525	A0A1L8GLC7	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	Uncharacterized protein.	0.873
A0A1L8G525	Kit.L	A0A1L8G525	A0A1L8HTR4	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.452
A0A1L8G525	Kit.S	A0A1L8G525	A0A1L8HL85	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.452
A0A1L8G525	hgf	A0A1L8G525	A0A1L8GTY1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.594
A0A1L8G525	hgf-2	A0A1L8G525	A0A1L8GZD1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.594
A0A1L8G525	il34	A0A1L8G525	A0A1L8GF18	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	Uncharacterized protein.	0.873
A0A1L8G525	itgb3	A0A1L8G525	B7ZQZ8	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	Integrin beta; Belongs to the integrin beta chain family.	0.628
A0A1L8G525	sdc1	A0A1L8G525	A0A1L8GBM5	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.900
A0A1L8GFB1	A0A1L8GLA9	A0A1L8GFB1	A0A1L8GLA9	Aminotran_1_2 domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.900
A0A1L8GFB1	Got2.L	A0A1L8GFB1	A0A1L8GLG8	Aminotran_1_2 domain-containing protein.	Aspartate aminotransferase.	0.983
A0A1L8GFB1	Gpt2.L	A0A1L8GFB1	A0A1L8G0C1	Aminotran_1_2 domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.901
A0A1L8GFB1	got1	A0A1L8GFB1	Q7ZTK9	Aminotran_1_2 domain-containing protein.	Aspartate aminotransferase.	0.986
A0A1L8GFB1	got2	A0A1L8GFB1	A0A1L8GFD3	Aminotran_1_2 domain-containing protein.	Aspartate aminotransferase.	0.983
A0A1L8GLA9	A0A1L8GFB1	A0A1L8GLA9	A0A1L8GFB1	Aminotran_1_2 domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.900
A0A1L8GLA9	Got2.L	A0A1L8GLA9	A0A1L8GLG8	Aminotran_1_2 domain-containing protein.	Aspartate aminotransferase.	0.983
A0A1L8GLA9	Gpt2.L	A0A1L8GLA9	A0A1L8G0C1	Aminotran_1_2 domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.901
A0A1L8GLA9	got1	A0A1L8GLA9	Q7ZTK9	Aminotran_1_2 domain-containing protein.	Aspartate aminotransferase.	0.986
A0A1L8GLA9	got2	A0A1L8GLA9	A0A1L8GFD3	Aminotran_1_2 domain-containing protein.	Aspartate aminotransferase.	0.983
Got2.L	A0A1L8GFB1	A0A1L8GLG8	A0A1L8GFB1	Aspartate aminotransferase.	Aminotran_1_2 domain-containing protein.	0.983
Got2.L	A0A1L8GLA9	A0A1L8GLG8	A0A1L8GLA9	Aspartate aminotransferase.	Aminotran_1_2 domain-containing protein.	0.983