90 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
	fzd2	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
	itgb4	Integrin beta. (1770 aa)
	itgb5	Integrin beta; Belongs to the integrin beta chain family. (808 aa)
	A0A1L8ENI4	Uncharacterized protein. (815 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	stat3.1	Signal transducer and activator of transcription. (769 aa)
	itgb4-2	Integrin beta. (1770 aa)
	A0A1L8EUY4	Uncharacterized protein. (818 aa)
	Itgb5.L	Integrin beta; Belongs to the integrin beta chain family. (808 aa)
	itgb6	Integrin beta; Belongs to the integrin beta chain family. (780 aa)
	Itgb2.S	Integrin beta. (769 aa)
	A0A1L8F270	FERM domain-containing protein. (580 aa)
	Zbtb33.S	Uncharacterized protein. (801 aa)
	golph3l	Uncharacterized protein. (280 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	golph3l-2	Uncharacterized protein. (278 aa)
	tnks2	Poly [ADP-ribose] polymerase. (1165 aa)
	Sfrp5.S	Uncharacterized protein. (315 aa)
	kras	Uncharacterized protein. (186 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	gdf2	TGF_BETA_2 domain-containing protein. (409 aa)
	axin2	Uncharacterized protein. (707 aa)
	itgb1	Integrin beta; Belongs to the integrin beta chain family. (884 aa)
	Itgb8.S	Integrin beta; Belongs to the integrin beta chain family. (726 aa)
	Myc.S	Myc_N domain-containing protein. (176 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Itgb1.L	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	itgb8	Integrin beta; Belongs to the integrin beta chain family. (809 aa)
	ptk2b	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1013 aa)
	rspo3	Uncharacterized protein. (253 aa)
	ptk2b-2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1014 aa)
	Cdh3.S	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
	calb2	Uncharacterized protein. (272 aa)
	wls	Uncharacterized protein. (541 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	cdh1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
	cdh3	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	calb2-2	Uncharacterized protein. (272 aa)
	Wls.L	Uncharacterized protein. (541 aa)
	Jun.L	BZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
	A0A1L8GTE5	Uncharacterized protein. (2543 aa)
	Met.S	Uncharacterized protein. (1354 aa)
	Met.L	Uncharacterized protein. (1355 aa)
	A0A1L8H034	Uncharacterized protein. (2543 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	khdrbs1	KH domain-containing protein. (360 aa)
	nck2	Cytoplasmic protein. (381 aa)
	arhgef7	Uncharacterized protein. (818 aa)
	itgbl1	Uncharacterized protein. (488 aa)
	rdx	FERM domain-containing protein. (602 aa)
	A0A1L8HG68	FERM domain-containing protein. (638 aa)
	nck2-2	Cytoplasmic protein. (381 aa)
	arhgef7-2	Uncharacterized protein. (802 aa)
	Itgbl1.L	Uncharacterized protein. (488 aa)
	itgb7	Integrin beta; Belongs to the integrin beta chain family. (766 aa)
	A0A1L8HJ91	FERM domain-containing protein. (557 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	lef1	HMG box domain-containing protein. (372 aa)
	tnks	Poly [ADP-ribose] polymerase. (1298 aa)
	Nf2.S	FERM domain-containing protein. (584 aa)
	Golph3.S	Uncharacterized protein. (290 aa)
	Nf2.L	FERM domain-containing protein. (583 aa)
	pxn	Uncharacterized protein; Belongs to the paxillin family. (542 aa)
	A0A1L8I385	Uncharacterized protein. (2303 aa)
	Tln2.S	Uncharacterized protein. (2612 aa)
	pten	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	cr1	Cripto-1. (190 aa)
	itgb3	Integrin beta; Belongs to the integrin beta chain family. (788 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	cdh11-2	Cadherin; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)
	nck1	Cytoplasmic protein. (377 aa)
	src	Tyrosine-protein kinase. (532 aa)
	nck1-2	Cytoplasmic protein. (377 aa)
	rac1	MGC114731 protein. (192 aa)
	krasl	Uncharacterized protein. (187 aa)
	golph3	LOC495055 protein. (288 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	axin2-2	MGC81576 protein. (707 aa)
	kras-2	Uncharacterized protein. (187 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	rhoa	MGC64296 protein. (193 aa)
	ccnd1	Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
	sfrp5	Secreted frizzled-related protein 5. (315 aa)
	hras	Small G-protein H-Ras. (189 aa)
	lef1-2	Lymphoid enhancer factor XLEF-1. (372 aa)
	kras-3	LOC397771 protein. (186 aa)
	pxn-2	LOC397826 protein; Belongs to the paxillin family. (539 aa)
	c-Jun	C-Jun protein; Belongs to the bZIP family. (312 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENI4	A0A1L8H5Q6	A0A1L8ENI4	A0A1L8H5Q6	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.998
A0A1L8ENI4	Cdh3.S	A0A1L8ENI4	A0A1L8GET9	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.538
A0A1L8ENI4	Jun.L	A0A1L8ENI4	A0A1L8GLZ4	Uncharacterized protein.	BZIP domain-containing protein; Belongs to the bZIP family.	0.535
A0A1L8ENI4	Lrp5.L	A0A1L8ENI4	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.928
A0A1L8ENI4	Myc.S	A0A1L8ENI4	A0A1L8FTW7	Uncharacterized protein.	Myc_N domain-containing protein.	0.692
A0A1L8ENI4	Sfrp5.S	A0A1L8ENI4	A0A1L8FEX3	Uncharacterized protein.	Uncharacterized protein.	0.543
A0A1L8ENI4	Tp53.L	A0A1L8ENI4	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.591
A0A1L8ENI4	Wls.L	A0A1L8ENI4	A0A1L8GLU8	Uncharacterized protein.	Uncharacterized protein.	0.674
A0A1L8ENI4	c-Jun	A0A1L8ENI4	Q9PVZ1	Uncharacterized protein.	C-Jun protein; Belongs to the bZIP family.	0.535
A0A1L8ENI4	ccnd1	A0A1L8ENI4	Q8AVQ4	Uncharacterized protein.	Ccnd1-prov protein; Belongs to the cyclin family.	0.853
A0A1L8ENI4	cdh1	A0A1L8ENI4	A0A1L8GKV4	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.562
A0A1L8ENI4	cdh3	A0A1L8ENI4	A0A1L8GKW6	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.562
A0A1L8ENI4	ctnnb1	A0A1L8ENI4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.998
A0A1L8ENI4	dkk1	A0A1L8ENI4	A0A1L8FIS6	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.899
A0A1L8ENI4	dkk1-2	A0A1L8ENI4	O57464	Uncharacterized protein.	Dickkopf homolog 1.	0.900
A0A1L8ENI4	fzd2	A0A1L8ENI4	A0A1L8EL29	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.694
A0A1L8ENI4	lef1	A0A1L8ENI4	A0A1L8HM07	Uncharacterized protein.	HMG box domain-containing protein.	0.922
A0A1L8ENI4	lef1-2	A0A1L8ENI4	Q90ZB8	Uncharacterized protein.	Lymphoid enhancer factor XLEF-1.	0.922
A0A1L8ENI4	myc	A0A1L8ENI4	Q6NRN4	Uncharacterized protein.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.776
A0A1L8ENI4	rspo3	A0A1L8ENI4	A0A1L8G886	Uncharacterized protein.	Uncharacterized protein.	0.526