95 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	Sox2.S	HMG box domain-containing protein. (194 aa)
	Nfatc2.S	RHD domain-containing protein. (884 aa)
	A0A1L8ENI4	Uncharacterized protein. (815 aa)
	wnt10a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	wnt9b.2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	nfatc2	RHD domain-containing protein. (896 aa)
	A0A1L8EUY4	Uncharacterized protein. (818 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	abcc1	Uncharacterized protein. (1507 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	A0A1L8F3L0	Uncharacterized protein. (2377 aa)
	taz	Tafazzin family protein; Belongs to the taffazin family. (262 aa)
	notch1	Uncharacterized protein. (2521 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	A0A1L8FAA5	Uncharacterized protein. (1077 aa)
	tnks2	Poly [ADP-ribose] polymerase. (1165 aa)
	Sfrp5.S	Uncharacterized protein. (315 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	wnt4-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	axin2	Uncharacterized protein. (707 aa)
	Rock1.S	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1367 aa)
	Myc.S	Myc_N domain-containing protein. (176 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Fzd8.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	fzd1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
	sfrp4	Uncharacterized protein. (353 aa)
	Rock1.L	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1360 aa)
	Rad21.L	Uncharacterized protein. (629 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	rock2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1399 aa)
	abcc5	Uncharacterized protein. (1437 aa)
	ryk	Uncharacterized protein. (596 aa)
	Rock2.L	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1373 aa)
	Cdh3.S	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	nfatc3	RHD domain-containing protein. (885 aa)
	nkd1	EF-hand domain-containing protein. (453 aa)
	cdh1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
	cdh3	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	Jun.L	BZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
	Rho.L	Rhodopsin. (459 aa)
	Wnt5b.S	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
	Met.S	Uncharacterized protein. (1354 aa)
	wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
	lgr5	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	ppp2r2b	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
	wif1	Uncharacterized protein. (374 aa)
	Lgr5.L	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	Met.L	Uncharacterized protein. (1355 aa)
	wnt16-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
	A0A1L8H4P9	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (469 aa)
	A0A1L8H5Z7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (534 aa)
	A0A1L8H7Y4	Runt-related transcription factor. (395 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	Mmp13.S	ZnMc domain-containing protein. (258 aa)
	Aldh3a2.L	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (483 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	Yap1.L	Uncharacterized protein. (459 aa)
	Mmp7.L	ZnMc domain-containing protein. (259 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	tnks	Poly [ADP-ribose] polymerase. (1298 aa)
	ror2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	sfrp2	Uncharacterized protein. (295 aa)
	aldh3b1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (502 aa)
	fos	BZIP domain-containing protein. (369 aa)
	wnt6-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	nf-at	Nuclear factor of activated T-cell. (884 aa)
	Xwnt-8b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (428 aa)
	wnt10a-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	xfz8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	PIK3R1	Phosphoinositide-3-kinase. (722 aa)
	nlk	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (533 aa)
	runx3	Runt-related transcription factor. (393 aa)
	wnt7b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	rac1	MGC114731 protein. (192 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	axin2-2	MGC81576 protein. (707 aa)
	fos-2	MGC80305 protein. (368 aa)
	rad21	LOC503676 protein. (629 aa)
	Xporc-d	Xporc-d protein; Belongs to the membrane-bound acyltransferase family. (450 aa)
	aldh3a2	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (506 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	rhoa	MGC64296 protein. (193 aa)
	sfrp2-2	Sfrp2-prov protein. (298 aa)
	ror2-2	Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	ccnd1	Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
	sfrp5	Secreted frizzled-related protein 5. (315 aa)
	c-Jun	C-Jun protein; Belongs to the bZIP family. (312 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENI4	A0A1L8H5Z7	A0A1L8ENI4	A0A1L8H5Z7	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.504
A0A1L8ENI4	Cdh3.S	A0A1L8ENI4	A0A1L8GET9	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.538
A0A1L8ENI4	Fzd8.L	A0A1L8ENI4	A0A1L8FVD0	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.635
A0A1L8ENI4	Jun.L	A0A1L8ENI4	A0A1L8GLZ4	Uncharacterized protein.	BZIP domain-containing protein; Belongs to the bZIP family.	0.535
A0A1L8ENI4	Lgr5.L	A0A1L8ENI4	A0A1L8GYN0	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.817
A0A1L8ENI4	Lrp5.L	A0A1L8ENI4	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.928
A0A1L8ENI4	Mmp13.S	A0A1L8ENI4	A0A1L8HAT6	Uncharacterized protein.	ZnMc domain-containing protein.	0.417
A0A1L8ENI4	Myc.S	A0A1L8ENI4	A0A1L8FTW7	Uncharacterized protein.	Myc_N domain-containing protein.	0.692
A0A1L8ENI4	Notch1.S	A0A1L8ENI4	A0A1L8F124	Uncharacterized protein.	Uncharacterized protein.	0.558
A0A1L8ENI4	Sfrp5.S	A0A1L8ENI4	A0A1L8FEX3	Uncharacterized protein.	Uncharacterized protein.	0.543
A0A1L8ENI4	Sox2.S	A0A1L8ENI4	A0A1L8EK54	Uncharacterized protein.	HMG box domain-containing protein.	0.445
A0A1L8ENI4	Wnt1.L	A0A1L8ENI4	A0A1L8HHR8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.872
A0A1L8ENI4	Wnt5b.S	A0A1L8ENI4	A0A1L8GQS0	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.601
A0A1L8ENI4	Xporc-d	A0A1L8ENI4	Q6DFF3	Uncharacterized protein.	Xporc-d protein; Belongs to the membrane-bound acyltransferase family.	0.460
A0A1L8ENI4	Xwnt-8b	A0A1L8ENI4	B7ZQM6	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.719
A0A1L8ENI4	c-Jun	A0A1L8ENI4	Q9PVZ1	Uncharacterized protein.	C-Jun protein; Belongs to the bZIP family.	0.535
A0A1L8ENI4	ccnd1	A0A1L8ENI4	Q8AVQ4	Uncharacterized protein.	Ccnd1-prov protein; Belongs to the cyclin family.	0.853
A0A1L8ENI4	cdh1	A0A1L8ENI4	A0A1L8GKV4	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.562
A0A1L8ENI4	cdh3	A0A1L8ENI4	A0A1L8GKW6	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.562
A0A1L8ENI4	ctnnb1	A0A1L8ENI4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.998