STRINGSTRING
hdac7 hdac7 tnfsf11 tnfsf11 sin3a sin3a Hdac3.S Hdac3.S Prkacb.S Prkacb.S prkacb prkacb bdnf bdnf tbl1xr1-2 tbl1xr1-2 A0A1L8G8Y0 A0A1L8G8Y0 echdc1 echdc1 tbl1xr1 tbl1xr1 A0A1L8G2V6 A0A1L8G2V6 hist2h3c hist2h3c Dlx5.L Dlx5.L Drosha.S Drosha.S dlx5 dlx5 ybx1 ybx1 Sirt1.L Sirt1.L sirt1 sirt1 nemf nemf atrx atrx Hdac6.L Hdac6.L Hif-1a Hif-1a foxg1 foxg1 A0A1L8EY07 A0A1L8EY07 Hdac4.L Hdac4.L slc12a5 slc12a5 hdac5 hdac5 hdac4 hdac4 Hdac5.S Hdac5.S h3f3b h3f3b klf9 klf9 prkaca prkaca hdac1-2 hdac1-2 hif1a hif1a bdnf-2 bdnf-2 cdk10 cdk10 A0A310TTQ1 A0A310TTQ1 hdac7-2 hdac7-2 Tnfsf11.L Tnfsf11.L hdac1 hdac1 Ncor1.L Ncor1.L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hdac7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (972 aa)
tnfsf11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (290 aa)
sin3aHDAC_interact domain-containing protein. (1273 aa)
Hdac3.SHistone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (405 aa)
Prkacb.SUncharacterized protein; Belongs to the protein kinase superfamily. (338 aa)
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (396 aa)
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (247 aa)
tbl1xr1-2Uncharacterized protein. (513 aa)
A0A1L8G8Y0Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
echdc1Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (299 aa)
tbl1xr1Uncharacterized protein. (522 aa)
A0A1L8G2V6Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (467 aa)
hist2h3cHistone H3; Belongs to the histone H3 family. (136 aa)
Dlx5.LHomeobox domain-containing protein. (298 aa)
Drosha.SUncharacterized protein. (1308 aa)
dlx5Homeobox domain-containing protein. (297 aa)
ybx1CSD_1 domain-containing protein. (303 aa)
Sirt1.LDeacetylase sirtuin-type domain-containing protein. (722 aa)
sirt1Deacetylase sirtuin-type domain-containing protein. (722 aa)
nemfUncharacterized protein. (1070 aa)
atrxUncharacterized protein. (2276 aa)
Hdac6.LHist_deacetyl domain-containing protein. (564 aa)
Hif-1aUncharacterized protein. (800 aa)
foxg1Fork-head domain-containing protein. (418 aa)
A0A1L8EY07Histone H3; Belongs to the histone H3 family. (120 aa)
Hdac4.LHistone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1171 aa)
slc12a5Uncharacterized protein. (1100 aa)
hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1016 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
Hdac5.SHistone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1048 aa)
h3f3bHistone H3; Belongs to the histone H3 family. (136 aa)
klf9Basic transcription element binding protein 1. (292 aa)
prkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
hdac1-2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
hif1aHif1a-prov protein. (802 aa)
bdnf-2Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (247 aa)
cdk10LOC100036925 protein; Belongs to the protein kinase superfamily. (350 aa)
A0A310TTQ1Histone H3; Belongs to the histone H3 family. (136 aa)
hdac7-2Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (957 aa)
Tnfsf11.LTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (290 aa)
hdac1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
Ncor1.LUncharacterized protein. (2518 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.