27 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	vav1	Vav1-prov protein. (845 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1280 aa)
	Cd3g.S	Ig-like domain-containing protein. (217 aa)
	cbl	Uncharacterized protein. (887 aa)
	inpp5d	SH2 domain-containing protein. (1099 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	pxdn	Uncharacterized protein. (1461 aa)
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	Inpp5d.L	SH2 domain-containing protein. (1111 aa)
	pxdn-2	Uncharacterized protein. (1464 aa)
	rag1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1045 aa)
	rag1-2	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1045 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
	Cd247.L	Uncharacterized protein. (217 aa)
	lck	Tyrosine-protein kinase. (503 aa)
	Lck.L	Tyrosine-protein kinase. (502 aa)
	Vcp.S	Uncharacterized protein; Belongs to the AAA ATPase family. (805 aa)
	pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
	Plcg1.S	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1260 aa)
	src	Tyrosine-protein kinase. (532 aa)
	zap70	Tyrosine-protein kinase. (617 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	Gapdh.S	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cd247.L	Cd3g.S	A0A1L8H5J4	A0A1L8FFZ8	Uncharacterized protein.	Ig-like domain-containing protein.	0.998
Cd247.L	Lck.L	A0A1L8H5J4	A0A1L8HFJ7	Uncharacterized protein.	Tyrosine-protein kinase.	0.917
Cd247.L	Plcg1.S	A0A1L8H5J4	A0A310TNX3	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.619
Cd247.L	Ptpn11.S	A0A1L8H5J4	Q92124	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.651
Cd247.L	lck	A0A1L8H5J4	A0A1L8H7S2	Uncharacterized protein.	Tyrosine-protein kinase.	0.917
Cd247.L	pik3cb	A0A1L8H5J4	A0A1L8G4U9	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.402
Cd247.L	pik3cb-2	A0A1L8H5J4	A0A1L8GB27	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.402
Cd247.L	plcg1	A0A1L8H5J4	A0A1L8EU11	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.618
Cd247.L	ptpn11b	A0A1L8H5J4	Q6GP31	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.654
Cd247.L	src	A0A1L8H5J4	Q2TAR1	Uncharacterized protein.	Tyrosine-protein kinase.	0.667
Cd247.L	vav1	A0A1L8H5J4	Q6DCX0	Uncharacterized protein.	Vav1-prov protein.	0.534
Cd247.L	zap70	A0A1L8H5J4	Q6DCV6	Uncharacterized protein.	Tyrosine-protein kinase.	0.997
Cd3g.S	Cd247.L	A0A1L8FFZ8	A0A1L8H5J4	Ig-like domain-containing protein.	Uncharacterized protein.	0.998
Cd3g.S	Lck.L	A0A1L8FFZ8	A0A1L8HFJ7	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.713
Cd3g.S	Ptpn11.S	A0A1L8FFZ8	Q92124	Ig-like domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.456
Cd3g.S	lck	A0A1L8FFZ8	A0A1L8H7S2	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.713
Cd3g.S	ptpn11b	A0A1L8FFZ8	Q6GP31	Ig-like domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.456
Cd3g.S	src	A0A1L8FFZ8	Q2TAR1	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.569
Cd3g.S	zap70	A0A1L8FFZ8	Q6DCV6	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.892
Gapdh.S	Vcp.S	Q7ZY52	A0A1L8HSA2	Glyceraldehyde-3-phosphate dehydrogenase.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.441