51 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Shh.L	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Myc.S	Myc_N domain-containing protein. (176 aa)
	nfatc1	RHD domain-containing protein. (955 aa)
	Hoxa13.S	Homeobox domain-containing protein. (295 aa)
	prom1	Uncharacterized protein. (796 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	ctbp2	Uncharacterized protein. (973 aa)
	A0A1L8FJ10	Uncharacterized protein. (987 aa)
	fzd2	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
	Nfatc2.S	RHD domain-containing protein. (884 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	A0A1L8ES96	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (554 aa)
	nfatc2	RHD domain-containing protein. (896 aa)
	axin1	Uncharacterized protein. (841 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	notch1	Uncharacterized protein. (2521 aa)
	c-Jun	C-Jun protein; Belongs to the bZIP family. (312 aa)
	lef1-2	Lymphoid enhancer factor XLEF-1. (372 aa)
	snai2-2	Zinc finger transcription factor slug beta. (266 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	Xporc-d	Xporc-d protein; Belongs to the membrane-bound acyltransferase family. (450 aa)
	soat1-2	O-acyltransferase. (550 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	LOC494997	LOC494997 protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (430 aa)
	cdh11-2	Cadherin; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)
	PIK3R1	Phosphoinositide-3-kinase. (722 aa)
	xfz8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	hoxa13	Homeobox domain-containing protein. (295 aa)
	Proml-1	Uncharacterized protein. (890 aa)
	ctbp1	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (441 aa)
	lef1	HMG box domain-containing protein. (372 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	Soat2.S	O-acyltransferase. (532 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	wnt16-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
	wif1	Uncharacterized protein. (374 aa)
	ctbp2l-2	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (437 aa)
	ctbp2l	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (480 aa)
	wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
	A0A1L8GQT6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	soat1	O-acyltransferase. (553 aa)
	Jun.L	BZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
	dgat1	O-acyltransferase. (472 aa)
	snai2	Uncharacterized protein. (266 aa)
	nfatc1-2	RHD domain-containing protein. (933 aa)
	Abcb1.L	Uncharacterized protein. (1286 aa)
	Zeb1.S	Uncharacterized protein. (919 aa)
	Fzd8.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ES96	A0A1L8GQT6	A0A1L8ES96	A0A1L8GQT6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.889
A0A1L8ES96	Axin1.S	A0A1L8ES96	A0A1L8ER48	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.528
A0A1L8ES96	ctnnb1	A0A1L8ES96	Q63ZT4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Beta-catenin protein.	0.702
A0A1L8ES96	wnt10b	A0A1L8ES96	A0A1L8HHS0	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.795
A0A1L8ES96	wnt11	A0A1L8ES96	A0A1L8HJX1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.880
A0A1L8ES96	wnt11b	A0A1L8ES96	A0A1L8F6W4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.878
A0A1L8ES96	wnt16	A0A1L8ES96	A0A1L8GU45	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.801
A0A1L8ES96	wnt16-2	A0A1L8ES96	A0A1L8GZ22	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.801
A0A1L8ES96	wnt3a	A0A1L8ES96	A0A1L8FUX8	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.883
A0A1L8FJ10	Zeb1.S	A0A1L8FJ10	A0A1L8FVG1	Uncharacterized protein.	Uncharacterized protein.	0.596
A0A1L8FJ10	ctnnb1	A0A1L8FJ10	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.753
A0A1L8FJ10	lef1	A0A1L8FJ10	A0A1L8HM07	Uncharacterized protein.	HMG box domain-containing protein.	0.880
A0A1L8FJ10	lef1-2	A0A1L8FJ10	Q90ZB8	Uncharacterized protein.	Lymphoid enhancer factor XLEF-1.	0.880
A0A1L8GQT6	A0A1L8ES96	A0A1L8GQT6	A0A1L8ES96	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.889
A0A1L8GQT6	A0A1L8H5Q6	A0A1L8GQT6	A0A1L8H5Q6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.853
A0A1L8GQT6	Axin1.S	A0A1L8GQT6	A0A1L8ER48	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Uncharacterized protein.	0.968
A0A1L8GQT6	Fzd8.L	A0A1L8GQT6	A0A1L8FVD0	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.958
A0A1L8GQT6	Myc.S	A0A1L8GQT6	A0A1L8FTW7	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Myc_N domain-containing protein.	0.428
A0A1L8GQT6	Xporc-d	A0A1L8GQT6	Q6DFF3	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Xporc-d protein; Belongs to the membrane-bound acyltransferase family.	0.427
A0A1L8GQT6	axin1	A0A1L8GQT6	A0A1L8EYQ2	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Uncharacterized protein.	0.795