(15 nodes) (2021) Melatonin modulates nitric oxide-regulated WNK-SPAKOSR1-NKCC1 signaling in dorsal raphe nucleus of rats. network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

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protein homology

Your Input:
	slc12a2	Uncharacterized protein. (1142 aa)
	wnk4	Protein kinase domain-containing protein. (1573 aa)
	wnk4-2	Protein kinase domain-containing protein. (1575 aa)
	slc12a5	Uncharacterized protein. (1100 aa)
	Wnk3.S	Protein kinase domain-containing protein. (2749 aa)
	Wnk1.S	Uncharacterized protein. (265 aa)
	stk24	Protein kinase domain-containing protein. (425 aa)
	Mtnr1a.S	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (307 aa)
	Nos1.S	Nitric oxide synthase; Produces nitric oxide (NO). (1391 aa)
	stk24-2	MGC80614 protein. (424 aa)
	oxsr1	Stk39 protein. (528 aa)
	slc12a2-2	Uncharacterized protein. (1158 aa)
	Nos1.L	Nitric oxide synthase; Produces nitric oxide (NO). (1419 aa)
	slc12a4	Uncharacterized protein. (1133 aa)
	Mtnr1a.L	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (395 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Nos1.L	Nos1.S	A0A1L8I1A8	A0A1L8HQU3	Nitric oxide synthase; Produces nitric oxide (NO).	Nitric oxide synthase; Produces nitric oxide (NO).	0.900
Nos1.S	Nos1.L	A0A1L8HQU3	A0A1L8I1A8	Nitric oxide synthase; Produces nitric oxide (NO).	Nitric oxide synthase; Produces nitric oxide (NO).	0.900
Wnk1.S	Wnk3.S	A0A1L8GQQ4	A0A1L8F1U7	Uncharacterized protein.	Protein kinase domain-containing protein.	0.693
Wnk1.S	oxsr1	A0A1L8GQQ4	A0JPG0	Uncharacterized protein.	Stk39 protein.	0.978
Wnk1.S	slc12a2	A0A1L8GQQ4	A0A1L8HQZ9	Uncharacterized protein.	Uncharacterized protein.	0.915
Wnk1.S	slc12a2-2	A0A1L8GQQ4	A0A1L8I1I1	Uncharacterized protein.	Uncharacterized protein.	0.915
Wnk1.S	slc12a4	A0A1L8GQQ4	A0A1L8HZL0	Uncharacterized protein.	Uncharacterized protein.	0.901
Wnk1.S	slc12a5	A0A1L8GQQ4	A0A1L8ETT5	Uncharacterized protein.	Uncharacterized protein.	0.854
Wnk1.S	stk24	A0A1L8GQQ4	A0A1L8H969	Uncharacterized protein.	Protein kinase domain-containing protein.	0.931
Wnk1.S	stk24-2	A0A1L8GQQ4	Q6GP83	Uncharacterized protein.	MGC80614 protein.	0.931
Wnk3.S	Wnk1.S	A0A1L8F1U7	A0A1L8GQQ4	Protein kinase domain-containing protein.	Uncharacterized protein.	0.693
Wnk3.S	oxsr1	A0A1L8F1U7	A0JPG0	Protein kinase domain-containing protein.	Stk39 protein.	0.712
Wnk3.S	slc12a2	A0A1L8F1U7	A0A1L8HQZ9	Protein kinase domain-containing protein.	Uncharacterized protein.	0.947
Wnk3.S	slc12a2-2	A0A1L8F1U7	A0A1L8I1I1	Protein kinase domain-containing protein.	Uncharacterized protein.	0.947
Wnk3.S	slc12a4	A0A1L8F1U7	A0A1L8HZL0	Protein kinase domain-containing protein.	Uncharacterized protein.	0.909
Wnk3.S	slc12a5	A0A1L8F1U7	A0A1L8ETT5	Protein kinase domain-containing protein.	Uncharacterized protein.	0.907
Wnk3.S	wnk4	A0A1L8F1U7	A0A1L8EMC7	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.642
Wnk3.S	wnk4-2	A0A1L8F1U7	A0A1L8ETQ6	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.639
oxsr1	Wnk1.S	A0JPG0	A0A1L8GQQ4	Stk39 protein.	Uncharacterized protein.	0.978
oxsr1	Wnk3.S	A0JPG0	A0A1L8F1U7	Stk39 protein.	Protein kinase domain-containing protein.	0.712