STRINGSTRING
calml4 calml4 A0A1L8EUY4 A0A1L8EUY4 wnt6 wnt6 fzd7 fzd7 A0A1L8EX52 A0A1L8EX52 nppb nppb A0A1L8F3F7 A0A1L8F3F7 tgfb1 tgfb1 wnt11b wnt11b tgfb1-2 tgfb1-2 ckb ckb crp.4 crp.4 rac3 rac3 c-Jun c-Jun lef1-2 lef1-2 ccnd1 ccnd1 ror2-2 ror2-2 ckm ckm sfrp2-2 sfrp2-2 pck1 pck1 g6pc-3 g6pc-3 g6pc.3-2 g6pc.3-2 g6pc-2 g6pc-2 stat5b stat5b myc myc slc2a2-2 slc2a2-2 adipoq-2 adipoq-2 g6pc g6pc axin2-2 axin2-2 ctnnb1 ctnnb1 nppb-2 nppb-2 sult2a1 sult2a1 fabp4 fabp4 rac1 rac1 lep-2 lep-2 vegfa vegfa il1b-A il1b-A Bmp1 Bmp1 LOC397803 LOC397803 Stat5a Stat5a ins-2 ins-2 nf-at nf-at Tfam.L Tfam.L wnt6-2 wnt6-2 tnf-2 tnf-2 art1 art1 pik3c3 pik3c3 sfrp2 sfrp2 Casp3.L Casp3.L ror2 ror2 lef1 lef1 casp3.2 casp3.2 wnt11 wnt11 foxo1-2 foxo1-2 Stat6.L Stat6.L stat2-2 stat2-2 Wnt1.L Wnt1.L A0A1L8HBU4 A0A1L8HBU4 A0A1L8HBK9 A0A1L8HBK9 A0A1L8HBJ3 A0A1L8HBJ3 Fzd4.S Fzd4.S foxo1 foxo1 wnt1 wnt1 A0A1L8H9R9 A0A1L8H9R9 stat2 stat2 Ren.S Ren.S A0A1L8H5Q6 A0A1L8H5Q6 Serpine1.L Serpine1.L bmp1 bmp1 Sfrp1.L Sfrp1.L Adam28.L Adam28.L A0A1L8H1M9 A0A1L8H1M9 Il1b.L Il1b.L calml4-2 calml4-2 lep lep nrf1 nrf1 Nrf1.S Nrf1.S Ckmt1b.L Ckmt1b.L Adam28.S Adam28.S sfrp1 sfrp1 Rho.L Rho.L Jun.L Jun.L nfatc3 nfatc3 Mmp2.S Mmp2.S ins ins Irs1.S Irs1.S tgfb2-2 tgfb2-2 calm1 calm1 adipoq adipoq agtr1 agtr1 slc2a2 slc2a2 sfrp4 sfrp4 wnt3a wnt3a Myc.S Myc.S Bcl2.S Bcl2.S axin2 axin2 A0A1L8FND1 A0A1L8FND1 Bax.L Bax.L A0A1L8EKE2 A0A1L8EKE2 acly acly Pck1.S Pck1.S g6pc.3 g6pc.3 G6pc.S G6pc.S A0A1L8ENI4 A0A1L8ENI4 A0A1L8EPW6 A0A1L8EPW6 fzd5 fzd5 srebf1 srebf1 Axin1.S Axin1.S Stat3.2.L Stat3.2.L stat3.1 stat3.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
calml4Uncharacterized protein. (153 aa)
A0A1L8EUY4Uncharacterized protein. (818 aa)
wnt6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
fzd7Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
A0A1L8EX52Signal transducer and activator of transcription. (1111 aa)
nppbUncharacterized protein. (137 aa)
A0A1L8F3F7Uncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
wnt11bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
tgfb1-2Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
ckbUncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
crp.4Pentaxin. (242 aa)
rac3RAC1 protein. (192 aa)
c-JunC-Jun protein; Belongs to the bZIP family. (312 aa)
lef1-2Lymphoid enhancer factor XLEF-1. (372 aa)
ccnd1Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
ror2-2Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
ckmCkm-prov protein; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
sfrp2-2Sfrp2-prov protein. (298 aa)
pck1Pck1-prov protein. (622 aa)
g6pc-3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
g6pc.3-2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
g6pc-2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
stat5bSignal transducer and activator of transcription. (781 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
slc2a2-2Slc2a2 protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (499 aa)
adipoq-2MGC84292 protein. (235 aa)
g6pcGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
axin2-2MGC81576 protein. (707 aa)
ctnnb1Beta-catenin protein. (781 aa)
nppb-2Natriuretic peptide type B. (137 aa)
sult2a1Sulfotransferase; Belongs to the sulfotransferase 1 family. (287 aa)
fabp4MGC84940 protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
rac1MGC114731 protein. (192 aa)
lep-2Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
vegfaVascular endothelial growth factor 196; Belongs to the PDGF/VEGF growth factor family. (194 aa)
il1b-AInterleukin-1; Belongs to the IL-1 family. (283 aa)
Bmp1Metalloendopeptidase. (977 aa)
LOC397803Cardiac troponin I. (244 aa)
Stat5aSignal transducer and activator of transcription. (781 aa)
ins-2Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
nf-atNuclear factor of activated T-cell. (884 aa)
Tfam.LUncharacterized protein. (283 aa)
wnt6-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
tnf-2Tumor necrosis factor alpha. (225 aa)
art1NAD(P)(+)--arginine ADP-ribosyltransferase. (317 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
sfrp2Uncharacterized protein. (295 aa)
Casp3.LUncharacterized protein; Belongs to the peptidase C14A family. (253 aa)
ror2Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
lef1HMG box domain-containing protein. (372 aa)
casp3.2Uncharacterized protein; Belongs to the peptidase C14A family. (288 aa)
wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
foxo1-2Fork-head domain-containing protein. (631 aa)
Stat6.LSignal transducer and activator of transcription. (791 aa)
stat2-2Signal transducer and activator of transcription. (770 aa)
Wnt1.LProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
A0A1L8HBU4NAD(P)(+)--arginine ADP-ribosyltransferase. (302 aa)
A0A1L8HBK9NAD(P)(+)--arginine ADP-ribosyltransferase. (317 aa)
A0A1L8HBJ3NAD(P)(+)--arginine ADP-ribosyltransferase. (296 aa)
Fzd4.SUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
foxo1Fork-head domain-containing protein. (626 aa)
wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
A0A1L8H9R9Signal transducer and activator of transcription. (743 aa)
stat2Signal transducer and activator of transcription. (753 aa)
Ren.SPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (366 aa)
A0A1L8H5Q6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
Serpine1.LSERPIN domain-containing protein; Belongs to the serpin family. (403 aa)
bmp1Metalloendopeptidase. (976 aa)
Sfrp1.LUncharacterized protein. (311 aa)
Adam28.LUncharacterized protein. (658 aa)
A0A1L8H1M9Interleukin-1. (282 aa)
Il1b.LInterleukin-1. (145 aa)
calml4-2Uncharacterized protein. (152 aa)
lepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
nrf1Nrf1_DNA-bind domain-containing protein. (523 aa)
Nrf1.SNrf1_DNA-bind domain-containing protein. (523 aa)
Ckmt1b.LUncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (447 aa)
Adam28.SUncharacterized protein. (769 aa)
sfrp1Uncharacterized protein. (311 aa)
Rho.LRhodopsin. (459 aa)
Jun.LBZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
nfatc3RHD domain-containing protein. (885 aa)
Mmp2.SUncharacterized protein. (656 aa)
insInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
Irs1.SUncharacterized protein. (1227 aa)
tgfb2-2Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
calm1Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
adipoqC1q domain-containing protein. (233 aa)
agtr1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
slc2a2MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (499 aa)
sfrp4Uncharacterized protein. (353 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
Myc.SMyc_N domain-containing protein. (176 aa)
Bcl2.SBH4_2 domain-containing protein. (253 aa)
axin2Uncharacterized protein. (707 aa)
A0A1L8FND1IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
Bax.LUncharacterized protein. (221 aa)
A0A1L8EKE2Signal transducer and activator of transcription. (760 aa)
aclyATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1101 aa)
Pck1.SUncharacterized protein. (622 aa)
g6pc.3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
G6pc.SGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
A0A1L8ENI4Uncharacterized protein. (815 aa)
A0A1L8EPW6Signal transducer and activator of transcription. (750 aa)
fzd5Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
srebf1BHLH domain-containing protein. (1159 aa)
Axin1.SUncharacterized protein. (839 aa)
Stat3.2.LSignal transducer and activator of transcription. (760 aa)
stat3.1Signal transducer and activator of transcription. (769 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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