(30 nodes) (2021) The human GID complex engages two independent modules for substrate recruitment. network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	A0A1L8F712	Serine protease; Belongs to the peptidase S1B family. (349 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	Gapdh.S	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	ypel5	Protein yippee-like; Belongs to the yippee family. (121 aa)
	mkln1-2	Mkln1-prov protein. (727 aa)
	emd	Xemd1 protein. (180 aa)
	Cbl.S	Uncharacterized protein. (945 aa)
	Rmnd5a.L	Uncharacterized protein. (391 aa)
	Nedd4l.S	Uncharacterized protein. (979 aa)
	A0A1L8HPJ8	Ubiquitin-like domain-containing protein. (125 aa)
	Fbp1	FBPase domain-containing protein; Belongs to the FBPase class 1 family. (338 aa)
	rmnd5a	Uncharacterized protein. (391 aa)
	htra2	PDZ domain-containing protein. (407 aa)
	A0A1L8HH08	CULLIN_2 domain-containing protein; Belongs to the cullin family. (753 aa)
	cul4a	CULLIN_2 domain-containing protein; Belongs to the cullin family. (753 aa)
	Cand1.L	TIP120 domain-containing protein. (1309 aa)
	mdm2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
	mkln1	LisH domain-containing protein. (726 aa)
	ube2h	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	dcaf1	LisH domain-containing protein. (1485 aa)
	cul3-2	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	WDR26	Uncharacterized protein. (606 aa)
	cul3	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	cbl	Uncharacterized protein. (887 aa)
	spop	Uncharacterized protein. (374 aa)
	spop-2	Uncharacterized protein. (374 aa)
	Gid8.L	Uncharacterized protein. (278 aa)
	Hgs.L	Uncharacterized protein. (749 aa)
	Uba1.S	UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. (1044 aa)
	Cul4b.S	CULLIN_2 domain-containing protein; Belongs to the cullin family. (866 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8F712	htra2	A0A1L8F712	A0A1L8HK51	Serine protease; Belongs to the peptidase S1B family.	PDZ domain-containing protein.	0.628
A0A1L8HH08	A0A1L8HPJ8	A0A1L8HH08	A0A1L8HPJ8	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Ubiquitin-like domain-containing protein.	0.860
A0A1L8HH08	Cand1.L	A0A1L8HH08	A0A1L8GYM8	CULLIN_2 domain-containing protein; Belongs to the cullin family.	TIP120 domain-containing protein.	0.829
A0A1L8HH08	Cul4b.S	A0A1L8HH08	A0A1L8F2P4	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.900
A0A1L8HH08	Gid8.L	A0A1L8HH08	A0A1L8ET73	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein.	0.478
A0A1L8HH08	Uba1.S	A0A1L8HH08	A0A1L8EZK6	CULLIN_2 domain-containing protein; Belongs to the cullin family.	UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family.	0.503
A0A1L8HH08	WDR26	A0A1L8HH08	A0A1L8G6N6	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein.	0.508
A0A1L8HH08	cul4a	A0A1L8HH08	A0A1L8H8X2	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.900
A0A1L8HH08	dcaf1	A0A1L8HH08	A0A1L8GHG5	CULLIN_2 domain-containing protein; Belongs to the cullin family.	LisH domain-containing protein.	0.922
A0A1L8HH08	mdm2	A0A1L8HH08	A0A1L8GYI7	CULLIN_2 domain-containing protein; Belongs to the cullin family.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.495
A0A1L8HH08	mkln1	A0A1L8HH08	A0A1L8GTL7	CULLIN_2 domain-containing protein; Belongs to the cullin family.	LisH domain-containing protein.	0.437
A0A1L8HH08	mkln1-2	A0A1L8HH08	Q6DCM2	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Mkln1-prov protein.	0.437
A0A1L8HH08	ypel5	A0A1L8HH08	Q6DEA6	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Protein yippee-like; Belongs to the yippee family.	0.679
A0A1L8HPJ8	A0A1L8HH08	A0A1L8HPJ8	A0A1L8HH08	Ubiquitin-like domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.860
A0A1L8HPJ8	Cand1.L	A0A1L8HPJ8	A0A1L8GYM8	Ubiquitin-like domain-containing protein.	TIP120 domain-containing protein.	0.950
A0A1L8HPJ8	Cbl.S	A0A1L8HPJ8	A0A310TNL8	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.672
A0A1L8HPJ8	Cul4b.S	A0A1L8HPJ8	A0A1L8F2P4	Ubiquitin-like domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.944
A0A1L8HPJ8	Hgs.L	A0A1L8HPJ8	A0A1L8ETK7	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.537
A0A1L8HPJ8	Nedd4l.S	A0A1L8HPJ8	A0A1L8HRV4	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.604
A0A1L8HPJ8	Uba1.S	A0A1L8HPJ8	A0A1L8EZK6	Ubiquitin-like domain-containing protein.	UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family.	0.922