STRINGSTRING
Nbn.L Nbn.L sumo2 sumo2 Sumo1.S Sumo1.S top1.1 top1.1 Sumo1.L Sumo1.L A0A1L8F712 A0A1L8F712 Tdp1.L Tdp1.L rad51 rad51 pnkp pnkp Nsmce2.L Nsmce2.L sprtn sprtn top1.2 top1.2 uba2 uba2 rad50 rad50 rad50-2 rad50-2 Dnmt1.L Dnmt1.L Rnf4-a Rnf4-a Paics.2.L Paics.2.L wrn wrn Chek2.L Chek2.L parp1 parp1 paics.1 paics.1 top2a top2a pcna pcna
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Nbn.LNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa)
sumo2Small ubiquitin-related modifier. (95 aa)
Sumo1.SUbiquitin-like domain-containing protein. (141 aa)
top1.1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (821 aa)
Sumo1.LUbiquitin-like domain-containing protein. (148 aa)
A0A1L8F712Serine protease; Belongs to the peptidase S1B family. (349 aa)
Tdp1.LUncharacterized protein. (597 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
pnkpFHA_2 domain-containing protein. (594 aa)
Nsmce2.LSP-RING-type domain-containing protein. (238 aa)
sprtnUncharacterized protein. (565 aa)
top1.2DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (770 aa)
uba2SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (641 aa)
rad50Zinc-hook domain-containing protein. (1311 aa)
rad50-2Zinc-hook domain-containing protein. (1312 aa)
Dnmt1.LDNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1488 aa)
Rnf4-aRING-type domain-containing protein. (190 aa)
Paics.2.LAIRC domain-containing protein. (958 aa)
wrnUncharacterized protein. (1434 aa)
Chek2.LUncharacterized protein. (392 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
paics.1MGC84289 protein. (425 aa)
top2aDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1579 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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