41 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Kremen2.S	Uncharacterized protein. (421 aa)
	rac3	RAC1 protein. (192 aa)
	dkk2-2	Dickkopf homolog 2. (255 aa)
	tcea1	TFIIS elongation factor. (303 aa)
	kras-3	LOC397771 protein. (186 aa)
	bmp4-2	Bone morphogenetic protein 4. (400 aa)
	hras	Small G-protein H-Ras. (189 aa)
	stat5b	Signal transducer and activator of transcription. (781 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	kras-2	Uncharacterized protein. (187 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	krasl	Uncharacterized protein. (187 aa)
	rac1	MGC114731 protein. (192 aa)
	src	Tyrosine-protein kinase. (532 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	kremen1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
	Kremen1.S	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (452 aa)
	A0A1L8HPP8	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (256 aa)
	dkk2	Dickkopf_N domain-containing protein. (255 aa)
	Yap1.L	Uncharacterized protein. (459 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	Lgr5.L	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	ifng	Uncharacterized protein. (182 aa)
	A0A1L8GUI6	Uncharacterized protein. (183 aa)
	lgr5	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	A0A1L8GQT6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	Dkk3.S	Dickkopf_N domain-containing protein. (257 aa)
	rag2	RAG2_PHD domain-containing protein. (520 aa)
	sfrp4	Uncharacterized protein. (353 aa)
	A0A1L8FW11	Uncharacterized protein. (139 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Myc.S	Myc_N domain-containing protein. (176 aa)
	Eomes.S	T-box_assoc domain-containing protein. (668 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	kras	Uncharacterized protein. (186 aa)
	taz	Tafazzin family protein; Belongs to the taffazin family. (262 aa)
	kremen2	Uncharacterized protein. (420 aa)
	cd40	TNFR-Cys domain-containing protein. (280 aa)
	stat3.1	Signal transducer and activator of transcription. (769 aa)
	Axin1.S	Uncharacterized protein. (839 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FW11	A0A1L8GUI6	A0A1L8FW11	A0A1L8GUI6	Uncharacterized protein.	Uncharacterized protein.	0.823
A0A1L8FW11	Tp53.L	A0A1L8FW11	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.481
A0A1L8FW11	cd40	A0A1L8FW11	A0A1L8ETV2	Uncharacterized protein.	TNFR-Cys domain-containing protein.	0.511
A0A1L8FW11	ctnnb1	A0A1L8FW11	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.475
A0A1L8FW11	ifng	A0A1L8FW11	A0A1L8GYI9	Uncharacterized protein.	Uncharacterized protein.	0.822
A0A1L8FW11	src	A0A1L8FW11	Q2TAR1	Uncharacterized protein.	Tyrosine-protein kinase.	0.456
A0A1L8FW11	stat3.1	A0A1L8FW11	A0A1L8ERT1	Uncharacterized protein.	Signal transducer and activator of transcription.	0.883
A0A1L8FW11	stat5b	A0A1L8FW11	Q6NU32	Uncharacterized protein.	Signal transducer and activator of transcription.	0.597
A0A1L8GQT6	Axin1.S	A0A1L8GQT6	A0A1L8ER48	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Uncharacterized protein.	0.968
A0A1L8GQT6	Dkk3.S	A0A1L8GQT6	A0A1L8GDZ7	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Dickkopf_N domain-containing protein.	0.551
A0A1L8GQT6	Kremen1.S	A0A1L8GQT6	A0A1L8HQW5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.882
A0A1L8GQT6	Kremen2.S	A0A1L8GQT6	A0A1L8ER80	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Uncharacterized protein.	0.876
A0A1L8GQT6	Lgr5.L	A0A1L8GQT6	A0A1L8GYN0	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.551
A0A1L8GQT6	Lrp5.L	A0A1L8GQT6	A0A1L8GJX4	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Uncharacterized protein.	0.984
A0A1L8GQT6	Myc.S	A0A1L8GQT6	A0A1L8FTW7	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Myc_N domain-containing protein.	0.428
A0A1L8GQT6	ctnnb1	A0A1L8GQT6	Q63ZT4	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Beta-catenin protein.	0.945
A0A1L8GQT6	dkk1	A0A1L8GQT6	A0A1L8FIS6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Dickkopf_N domain-containing protein.	0.999
A0A1L8GQT6	dkk1-2	A0A1L8GQT6	O57464	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Dickkopf homolog 1.	0.999
A0A1L8GQT6	dkk2	A0A1L8GQT6	A0A1L8HM80	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Dickkopf_N domain-containing protein.	0.988
A0A1L8GQT6	dkk2-2	A0A1L8GQT6	Q9DDA4	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Dickkopf homolog 2.	0.988