STRINGSTRING
ctnnb1 ctnnb1 DDX5 DDX5 krasl krasl neurog2-2 neurog2-2 neurog2 neurog2 dkk1-2 dkk1-2 vegfa vegfa wnt7b wnt7b pitx3 pitx3 xfz8 xfz8 fz3 fz3 rspo2 rspo2 wif1-2 wif1-2 spry1-2 spry1-2 wnt6-2 wnt6-2 pten pten znrf3 znrf3 kremen1 kremen1 spry1 spry1 sfrp2 sfrp2 fbxw7 fbxw7 Proml-1 Proml-1 Znrf3.S Znrf3.S Kremen1.S Kremen1.S dkk2 dkk2 lef1 lef1 Fut4.L Fut4.L Sp7.L Sp7.L wnt10b wnt10b Wnt1.L Wnt1.L Tnfsf11.L Tnfsf11.L sod1-2 sod1-2 Fzd4.S Fzd4.S yap1 yap1 Flt1.S Flt1.S wnt1 wnt1 tnfsf11 tnfsf11 Ren.S Ren.S rnf43 rnf43 A0A1L8H5Q6 A0A1L8H5Q6 sod1 sod1 Tp53.L Tp53.L Sfrp1.L Sfrp1.L Adgra2.L Adgra2.L hgf-2 hgf-2 wnt16-2 wnt16-2 wif1 wif1 wnt16 wnt16 hgf hgf pik3cg pik3cg sfrp1 sfrp1 Tmem59.L Tmem59.L cdh5-2 cdh5-2 Lrp5.L Lrp5.L lgr4 lgr4 Nell1.S Nell1.S Dhcr7.L Dhcr7.L cdh5 cdh5 nell1 nell1 ctcf ctcf Dkk3.S Dkk3.S dhcr7 dhcr7 Lgr4.S Lgr4.S Runx2.L Runx2.L ryk ryk pik3cb-2 pik3cb-2 gpc1-2 gpc1-2 Ghsr.L Ghsr.L Foxo3.L Foxo3.L Jag1.L Jag1.L fzd3 fzd3 pik3cb pik3cb gpc1 gpc1 Ghsr.S Ghsr.S tnik tnik foxo3 foxo3 Myb.S Myb.S Egln1.S Egln1.S jag1 jag1 Ranbp9.L Ranbp9.L foxc1-2 foxc1-2 sfrp4 sfrp4 ezh2 ezh2 fzd1 fzd1 Fzd8.L Fzd8.L Shh.L Shh.L insig1 insig1 wnt3a wnt3a Wnt9a.S Wnt9a.S Myc.S Myc.S wnt4-2 wnt4-2 thy1 thy1 cxcl12 cxcl12 Sirt1.L Sirt1.L prom1 prom1 dkk1 dkk1 Tcf7l2.L Tcf7l2.L kras kras gsk3a gsk3a axin2 axin2 wnt4 wnt4 Pitx3 Pitx3 sirt1 sirt1 dact1 dact1 tgfb1-2 tgfb1-2 gpc3 gpc3 A0A1L8F7V6 A0A1L8F7V6 muc1 muc1 tgfb1 tgfb1 A0A1L8F390 A0A1L8F390 Dact1.S Dact1.S glis2 glis2 Frzb-1 Frzb-1 neurod1 neurod1 foxc1 foxc1 Col1a1.S Col1a1.S fzd2 fzd2 Gnas.S Gnas.S notum notum A0A1L8ENI4 A0A1L8ENI4 nr4a2 nr4a2 Frzb.S Frzb.S Glis2.S Glis2.S Flcn.S Flcn.S stat3.1 stat3.1 col1a1 col1a1 Notum.L Notum.L foxk2 foxk2 A0A1L8EUY4 A0A1L8EUY4 wnt6 wnt6 nr4a2-2 nr4a2-2 dkk2-2 dkk2-2 kras-3 kras-3 lef1-2 lef1-2 hras hras ackr3-2 ackr3-2 ccnd1 ccnd1 sfrp2-2 sfrp2-2 flt1 flt1 ctcf-2 ctcf-2 myc myc neurod1-2 neurod1-2 Xporc-d Xporc-d kras-2 kras-2 axin2-2 axin2-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ctnnb1Beta-catenin protein. (781 aa)
DDX5DDX5 protein; Belongs to the DEAD box helicase family. (608 aa)
kraslUncharacterized protein. (187 aa)
neurog2-2Neurogenin-related 1b. (215 aa)
neurog2Neurogenin-related 1a. (214 aa)
dkk1-2Dickkopf homolog 1. (259 aa)
vegfaVascular endothelial growth factor 196; Belongs to the PDGF/VEGF growth factor family. (194 aa)
wnt7bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
pitx3Homeobox protein. (292 aa)
xfz8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
fz3Fz3 protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
rspo2R-spondin 2. (243 aa)
wif1-2Wnt inhibitory factor-1. (374 aa)
spry1-2Sprouty 1. (319 aa)
wnt6-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ptenPhosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
znrf3RING-type domain-containing protein. (854 aa)
kremen1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
spry1Uncharacterized protein. (342 aa)
sfrp2Uncharacterized protein. (295 aa)
fbxw7Uncharacterized protein. (706 aa)
Proml-1Uncharacterized protein. (890 aa)
Znrf3.SRING-type domain-containing protein. (848 aa)
Kremen1.SKremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (452 aa)
dkk2Dickkopf_N domain-containing protein. (255 aa)
lef1HMG box domain-containing protein. (372 aa)
Fut4.LGlyco_tran_10_N domain-containing protein. (363 aa)
Sp7.LUncharacterized protein. (427 aa)
wnt10bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
Wnt1.LProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
Tnfsf11.LTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (290 aa)
sod1-2Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (151 aa)
Fzd4.SUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
yap1Uncharacterized protein. (457 aa)
Flt1.SUncharacterized protein. (683 aa)
wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
tnfsf11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (290 aa)
Ren.SPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (366 aa)
rnf43RING-type domain-containing protein. (664 aa)
A0A1L8H5Q6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
sod1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (151 aa)
Tp53.LP53 domain-containing protein. (137 aa)
Sfrp1.LUncharacterized protein. (311 aa)
Adgra2.LUncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1306 aa)
hgf-2Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
wnt16-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
wif1Uncharacterized protein. (374 aa)
wnt16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
hgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
pik3cgUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
sfrp1Uncharacterized protein. (311 aa)
Tmem59.LUncharacterized protein. (342 aa)
cdh5-2Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (775 aa)
Lrp5.LUncharacterized protein. (1517 aa)
lgr4G_PROTEIN_RECEP_F1_2 domain-containing protein. (953 aa)
Nell1.SUncharacterized protein. (541 aa)
Dhcr7.LUncharacterized protein. (473 aa)
cdh5Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (774 aa)
nell1Uncharacterized protein. (808 aa)
ctcfUncharacterized protein. (746 aa)
Dkk3.SDickkopf_N domain-containing protein. (257 aa)
dhcr7Uncharacterized protein. (473 aa)
Lgr4.SG_PROTEIN_RECEP_F1_2 domain-containing protein. (956 aa)
Runx2.LRunt-related transcription factor. (455 aa)
rykUncharacterized protein. (596 aa)
pik3cb-2Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
gpc1-2Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (552 aa)
Ghsr.LG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (348 aa)
Foxo3.LFork-head domain-containing protein. (661 aa)
Jag1.LDelta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
fzd3Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
pik3cbUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
gpc1Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (552 aa)
Ghsr.SG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (348 aa)
tnikUncharacterized protein. (1326 aa)
foxo3Fork-head domain-containing protein. (656 aa)
Myb.SUncharacterized protein. (626 aa)
Egln1.SUncharacterized protein. (454 aa)
jag1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1206 aa)
Ranbp9.LUncharacterized protein. (533 aa)
foxc1-2Fork-head domain-containing protein. (495 aa)
sfrp4Uncharacterized protein. (353 aa)
ezh2Uncharacterized protein. (748 aa)
fzd1Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
Fzd8.LUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
Shh.LHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
insig1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (251 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
Wnt9a.SProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (528 aa)
Myc.SMyc_N domain-containing protein. (176 aa)
wnt4-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
thy1Ig-like domain-containing protein. (165 aa)
cxcl12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (89 aa)
Sirt1.LDeacetylase sirtuin-type domain-containing protein. (722 aa)
prom1Uncharacterized protein. (796 aa)
dkk1Dickkopf_N domain-containing protein. (263 aa)
Tcf7l2.LHMG box domain-containing protein. (482 aa)
krasUncharacterized protein. (186 aa)
gsk3aProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (424 aa)
axin2Uncharacterized protein. (707 aa)
wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
Pitx3Homeobox protein. (292 aa)
sirt1Deacetylase sirtuin-type domain-containing protein. (722 aa)
dact1Uncharacterized protein. (824 aa)
tgfb1-2Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
gpc3Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
A0A1L8F7V6G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
muc1SEA domain-containing protein. (692 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
A0A1L8F390Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (467 aa)
Dact1.SUncharacterized protein. (818 aa)
glis2Uncharacterized protein. (493 aa)
Frzb-1Uncharacterized protein. (319 aa)
neurod1Neurogenic differentiation factor. (352 aa)
foxc1Fork-head domain-containing protein. (492 aa)
Col1a1.SUncharacterized protein. (1449 aa)
fzd2Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
Gnas.SUncharacterized protein. (217 aa)
notumUncharacterized protein. (488 aa)
A0A1L8ENI4Uncharacterized protein. (815 aa)
nr4a2Uncharacterized protein. (591 aa)
Frzb.SUncharacterized protein. (319 aa)
Glis2.SUncharacterized protein. (481 aa)
Flcn.SUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
stat3.1Signal transducer and activator of transcription. (769 aa)
col1a1Uncharacterized protein. (1449 aa)
Notum.LUncharacterized protein. (386 aa)
foxk2Uncharacterized protein. (683 aa)
A0A1L8EUY4Uncharacterized protein. (818 aa)
wnt6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
nr4a2-2Uncharacterized protein. (591 aa)
dkk2-2Dickkopf homolog 2. (255 aa)
kras-3LOC397771 protein. (186 aa)
lef1-2Lymphoid enhancer factor XLEF-1. (372 aa)
hrasSmall G-protein H-Ras. (189 aa)
ackr3-2RDC1 like protein; Belongs to the G-protein coupled receptor 1 family. (370 aa)
ccnd1Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
sfrp2-2Sfrp2-prov protein. (298 aa)
flt1Vegf-B-prov protein. (687 aa)
ctcf-2Ctcf protein. (735 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
neurod1-2Neurogenic differentiation factor. (357 aa)
Xporc-dXporc-d protein; Belongs to the membrane-bound acyltransferase family. (450 aa)
kras-2Uncharacterized protein. (187 aa)
axin2-2MGC81576 protein. (707 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
Server load: low (22%) [HD]