(36 nodes) (2021) Membrane Melatonin Receptors Activated Cell Signaling in Physiology and Disease. network (Xenopus laevis)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

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Your Input:
	Mtnr1b	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (420 aa)
	Cyct.L	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (136 aa)
	rora-2	Uncharacterized protein. (464 aa)
	Tpm1.L	Uncharacterized protein; Belongs to the tropomyosin family. (326 aa)
	Tm7	Uncharacterized protein; Belongs to the tropomyosin family. (284 aa)
	rora	Uncharacterized protein. (461 aa)
	calml4	Uncharacterized protein. (153 aa)
	map2k1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
	Opsin	Rhodopsin. (403 aa)
	Rho.L	Rhodopsin. (459 aa)
	Prkacb.S	Uncharacterized protein; Belongs to the protein kinase superfamily. (338 aa)
	A0A1L8GHL0	Rhodopsin. (354 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (396 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	ptk2b-2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1014 aa)
	Sst.2	Somatostatin domain-containing protein. (157 aa)
	calm1	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	ptk2b	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1013 aa)
	Esr1.S	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	A0A1L8FW52	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	cycs	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	A0A1L8FND1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	prkcz	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (590 aa)
	cyct	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	prkaca	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	creb1	Creb1-prov protein. (324 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	sst	Preprosomatostatin 1a. (115 aa)
	rhoa	MGC64296 protein. (193 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	cyp19a1	p450arom-A protein; Belongs to the cytochrome P450 family. (500 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	ins-2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	il10-2	Uncharacterized protein. (170 aa)
	il10	Uncharacterized protein. (172 aa)
	calml4-2	Uncharacterized protein. (152 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FND1	A0A1L8FW52	A0A1L8FND1	A0A1L8FW52	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.583
A0A1L8FND1	A0A1L8GHL0	A0A1L8FND1	A0A1L8GHL0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Rhodopsin.	0.485
A0A1L8FND1	Cyct.L	A0A1L8FND1	A0A1L8EP92	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.582
A0A1L8FND1	Esr1.S	A0A1L8FND1	A0A1L8G265	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.724
A0A1L8FND1	Opsin	A0A1L8FND1	A0A1L8GPM0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Rhodopsin.	0.488
A0A1L8FND1	Prkacb.S	A0A1L8FND1	A0A1L8GLU4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.724
A0A1L8FND1	Rho.L	A0A1L8FND1	A0A1L8GPJ9	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Rhodopsin.	0.547
A0A1L8FND1	Sst.2	A0A1L8FND1	A0A1L8G9W6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Somatostatin domain-containing protein.	0.954
A0A1L8FND1	actl6a	A0A1L8FND1	Q7ZYI5	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Baf53a-pending-prov protein; Belongs to the actin family.	0.733
A0A1L8FND1	calm1	A0A1L8FND1	A0A1L8G5X8	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein; Belongs to the calmodulin family.	0.689
A0A1L8FND1	calml4	A0A1L8FND1	A0A1L8GSE0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.693
A0A1L8FND1	calml4-2	A0A1L8FND1	A0A1L8H184	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.693
A0A1L8FND1	creb1	A0A1L8FND1	Q8AVY5	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Creb1-prov protein.	0.586
A0A1L8FND1	ctnnb1	A0A1L8FND1	Q63ZT4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Beta-catenin protein.	0.706
A0A1L8FND1	cycs	A0A1L8FND1	A0A1L8FR74	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.583
A0A1L8FND1	cyct	A0A1L8FND1	A0A1L8EWA6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.582
A0A1L8FND1	cyp19a1	A0A1L8FND1	Q68FK0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	p450arom-A protein; Belongs to the cytochrome P450 family.	0.471
A0A1L8FND1	esr1	A0A1L8FND1	Q6W5G7	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.724
A0A1L8FND1	il10	A0A1L8FND1	A0A1L8H745	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.608
A0A1L8FND1	il10-2	A0A1L8FND1	A0A1L8HER6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.608