101 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	en1	Homeobox protein engrailed-like. (228 aa)
	A0A1L8ENI4	Uncharacterized protein. (815 aa)
	wnt10a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	ihh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
	Frzb.S	Uncharacterized protein. (319 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	Kremen2.S	Uncharacterized protein. (421 aa)
	A0A1L8EUY4	Uncharacterized protein. (818 aa)
	ihh-2	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	Frzb-1	Uncharacterized protein. (319 aa)
	kremen2	Uncharacterized protein. (420 aa)
	tsc1	Uncharacterized protein. (1104 aa)
	tnf	TNF_2 domain-containing protein. (227 aa)
	tsc1-2	Uncharacterized protein. (1102 aa)
	esr2	Uncharacterized protein. (548 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (722 aa)
	Sfrp5.S	Uncharacterized protein. (315 aa)
	A0A1L8FG40	Uncharacterized protein. (2091 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	Sirt1.L	Deacetylase sirtuin-type domain-containing protein. (722 aa)
	A0A1L8FLY9	Uncharacterized protein. (1971 aa)
	wnt4-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	zbtb40	Uncharacterized protein. (1344 aa)
	axin2	Uncharacterized protein. (707 aa)
	dlx5	Homeobox domain-containing protein. (297 aa)
	Wnt9a.S	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (528 aa)
	Dlx5.L	Homeobox domain-containing protein. (298 aa)
	sostdc1	CTCK domain-containing protein. (213 aa)
	sfrp4	Uncharacterized protein. (353 aa)
	bmp2	TGF_BETA_2 domain-containing protein. (398 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	Bmp2.L	TGF_BETA_2 domain-containing protein. (398 aa)
	calm1	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	ryk	Uncharacterized protein. (596 aa)
	Runx2.L	Runt-related transcription factor. (455 aa)
	lrp4	Uncharacterized protein. (1906 aa)
	Lgr4.S	G_PROTEIN_RECEP_F1_2 domain-containing protein. (956 aa)
	Dkk3.S	Dickkopf_N domain-containing protein. (257 aa)
	Traf6.S	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (556 aa)
	wls	Uncharacterized protein. (541 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (396 aa)
	Traf6.L	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (556 aa)
	lrp4-2	Uncharacterized protein. (1908 aa)
	lgr4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (953 aa)
	Prkacb.S	Uncharacterized protein; Belongs to the protein kinase superfamily. (338 aa)
	Wls.L	Uncharacterized protein. (541 aa)
	Jun.L	BZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
	Prkcd.S	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (806 aa)
	Rho.L	Rhodopsin. (459 aa)
	Wnt5b.S	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
	A0A1L8GQT6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	sfrp1	Uncharacterized protein. (311 aa)
	calml4	Uncharacterized protein. (153 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
	wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
	lgr5	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	wif1	Uncharacterized protein. (374 aa)
	Lgr5.L	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	wnt16-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
	mesd	Uncharacterized protein. (214 aa)
	calml4-2	Uncharacterized protein. (152 aa)
	Sfrp1.L	Uncharacterized protein. (311 aa)
	rnf43	RING-type domain-containing protein. (664 aa)
	tnfsf11	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (290 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	Sp7.S	Uncharacterized protein. (409 aa)
	sp1	Uncharacterized protein. (732 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	Tnfsf11.L	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (290 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	sp1-2	Uncharacterized protein. (722 aa)
	dkk2	Dickkopf_N domain-containing protein. (255 aa)
	Musk.S	Uncharacterized protein. (942 aa)
	Kremen1.S	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (452 aa)
	sfrp2	Uncharacterized protein. (295 aa)
	Egf.L	Uncharacterized protein. (1031 aa)
	kremen1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
	tnf-2	Tumor necrosis factor alpha. (225 aa)
	wnt6-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	wnt10a-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	wnt7b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	en1-2	Homeobox protein engrailed-like. (229 aa)
	rac1	MGC114731 protein. (192 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	axin2-2	MGC81576 protein. (707 aa)
	Xporc-d	Xporc-d protein; Belongs to the membrane-bound acyltransferase family. (450 aa)
	sostdc1-2	Wise-A. (213 aa)
	rhoa	MGC64296 protein. (193 aa)
	sfrp2-2	Sfrp2-prov protein. (298 aa)
	sfrp5	Secreted frizzled-related protein 5. (315 aa)
	prkaca	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	dkk2-2	Dickkopf homolog 2. (255 aa)
	c-Jun	C-Jun protein; Belongs to the bZIP family. (312 aa)
	rac3	RAC1 protein. (192 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENI4	A0A1L8GQT6	A0A1L8ENI4	A0A1L8GQT6	Uncharacterized protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.849
A0A1L8ENI4	Bmp2.L	A0A1L8ENI4	A0A1L8G5P4	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.432
A0A1L8ENI4	Dkk3.S	A0A1L8ENI4	A0A1L8GDZ7	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.527
A0A1L8ENI4	Frzb-1	A0A1L8ENI4	A0A1L8EWF4	Uncharacterized protein.	Uncharacterized protein.	0.459
A0A1L8ENI4	Frzb.S	A0A1L8ENI4	A0A1L8EPI8	Uncharacterized protein.	Uncharacterized protein.	0.459
A0A1L8ENI4	Fzd4.S	A0A1L8ENI4	A0A1L8HB90	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.665
A0A1L8ENI4	Jun.L	A0A1L8ENI4	A0A1L8GLZ4	Uncharacterized protein.	BZIP domain-containing protein; Belongs to the bZIP family.	0.535
A0A1L8ENI4	Lgr4.S	A0A1L8ENI4	A0A1L8GDQ5	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.599
A0A1L8ENI4	Lgr5.L	A0A1L8ENI4	A0A1L8GYN0	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.817
A0A1L8ENI4	Runx2.L	A0A1L8ENI4	A0A1L8GBU1	Uncharacterized protein.	Runt-related transcription factor.	0.492
A0A1L8ENI4	Sfrp1.L	A0A1L8ENI4	A0A1L8H1S5	Uncharacterized protein.	Uncharacterized protein.	0.753
A0A1L8ENI4	Sfrp5.S	A0A1L8ENI4	A0A1L8FEX3	Uncharacterized protein.	Uncharacterized protein.	0.543
A0A1L8ENI4	Wls.L	A0A1L8ENI4	A0A1L8GLU8	Uncharacterized protein.	Uncharacterized protein.	0.674
A0A1L8ENI4	Wnt1.L	A0A1L8ENI4	A0A1L8HHR8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.872
A0A1L8ENI4	Wnt5b.S	A0A1L8ENI4	A0A1L8GQS0	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.601
A0A1L8ENI4	Wnt9a.S	A0A1L8ENI4	A0A1L8FUX2	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.571
A0A1L8ENI4	Xporc-d	A0A1L8ENI4	Q6DFF3	Uncharacterized protein.	Xporc-d protein; Belongs to the membrane-bound acyltransferase family.	0.460
A0A1L8ENI4	bmp2	A0A1L8ENI4	A0A1L8G1N2	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.432
A0A1L8ENI4	c-Jun	A0A1L8ENI4	Q9PVZ1	Uncharacterized protein.	C-Jun protein; Belongs to the bZIP family.	0.535
A0A1L8ENI4	ctnnb1	A0A1L8ENI4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.998