24 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8F390	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (467 aa)
	notum	Uncharacterized protein. (488 aa)
	Frzb.S	Uncharacterized protein. (319 aa)
	Kremen2.S	Uncharacterized protein. (421 aa)
	Notum.L	Uncharacterized protein. (386 aa)
	Frzb-1	Uncharacterized protein. (319 aa)
	kremen2	Uncharacterized protein. (420 aa)
	gpc4	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (549 aa)
	gpc3	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	egfr	Receptor protein-tyrosine kinase. (1208 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	egfr-2	Receptor protein-tyrosine kinase. (1210 aa)
	tfrc	Uncharacterized protein. (775 aa)
	tfrc-2	Uncharacterized protein. (775 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	A0A1L8GQT6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	gpc6	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (563 aa)
	A0A1L8HH89	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (235 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	gpc4-2	Xgly4 protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	cav1a	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8F390	Lrp5.L	A0A1L8F390	A0A1L8GJX4	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Uncharacterized protein.	0.473
A0A1L8F390	Notum.L	A0A1L8F390	A0A1L8ETE8	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Uncharacterized protein.	0.795
A0A1L8F390	gpc4	A0A1L8F390	A0A1L8F395	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.410
A0A1L8F390	gpc4-2	A0A1L8F390	Q5EAV3	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Xgly4 protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.410
A0A1L8F390	notum	A0A1L8F390	A0A1L8EM91	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Uncharacterized protein.	0.795
A0A1L8F390	wnt3a	A0A1L8F390	A0A1L8FUX8	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.558
A0A1L8GQT6	Kremen2.S	A0A1L8GQT6	A0A1L8ER80	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Uncharacterized protein.	0.876
A0A1L8GQT6	Lrp5.L	A0A1L8GQT6	A0A1L8GJX4	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Uncharacterized protein.	0.984
A0A1L8GQT6	cav1a	A0A1L8GQT6	Q6IRP8	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.800
A0A1L8GQT6	ctnnb1	A0A1L8GQT6	Q63ZT4	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Beta-catenin protein.	0.945
A0A1L8GQT6	dkk1	A0A1L8GQT6	A0A1L8FIS6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Dickkopf_N domain-containing protein.	0.999
A0A1L8GQT6	dkk1-2	A0A1L8GQT6	O57464	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Dickkopf homolog 1.	0.999
A0A1L8GQT6	egfr	A0A1L8GQT6	A0A1L8FRS8	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Receptor protein-tyrosine kinase.	0.472
A0A1L8GQT6	egfr-2	A0A1L8GQT6	A0A1L8FWP8	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Receptor protein-tyrosine kinase.	0.472
A0A1L8GQT6	kremen2	A0A1L8GQT6	A0A1L8EYY0	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Uncharacterized protein.	0.876
A0A1L8GQT6	tfrc	A0A1L8GQT6	A0A1L8G3V8	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Uncharacterized protein.	0.415
A0A1L8GQT6	tfrc-2	A0A1L8GQT6	A0A1L8G9X7	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Uncharacterized protein.	0.415
A0A1L8GQT6	wnt3a	A0A1L8GQT6	A0A1L8FUX8	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.988
A0A1L8HH89	Notum.L	A0A1L8HH89	A0A1L8ETE8	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Uncharacterized protein.	0.677
A0A1L8HH89	notum	A0A1L8HH89	A0A1L8EM91	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Uncharacterized protein.	0.677