STRINGSTRING
Sumo1.L Sumo1.L A0A1L8EY07 A0A1L8EY07 sae1 sae1 Tdp1.L Tdp1.L Tdp2.S Tdp2.S Nsmce2.L Nsmce2.L hist2h3c hist2h3c sprtn sprtn Znf451.L Znf451.L top1.2 top1.2 uba2 uba2 pias1 pias1 Pias1.L Pias1.L Srsf1.L Srsf1.L Pias4.S Pias4.S plaa plaa smc5 smc5 Rnf4-a Rnf4-a Pias4.L Pias4.L A0A310TTQ1 A0A310TTQ1 Clspn.S Clspn.S plaa-2 plaa-2 parp1 parp1 rnf4 rnf4 pias3 pias3 ufd1 ufd1 ufd1-2 ufd1-2 top2a top2a sumo2 sumo2 h3f3b h3f3b Sumo1.S Sumo1.S top1.1 top1.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sumo1.LUbiquitin-like domain-containing protein. (148 aa)
A0A1L8EY07Histone H3; Belongs to the histone H3 family. (120 aa)
sae1ThiF domain-containing protein. (344 aa)
Tdp1.LUncharacterized protein. (597 aa)
Tdp2.SEndo/exonuclease/phosphatase domain-containing protein. (382 aa)
Nsmce2.LSP-RING-type domain-containing protein. (238 aa)
hist2h3cHistone H3; Belongs to the histone H3 family. (136 aa)
sprtnUncharacterized protein. (565 aa)
Znf451.LUncharacterized protein. (1207 aa)
top1.2DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (770 aa)
uba2SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (641 aa)
pias1Uncharacterized protein. (640 aa)
Pias1.LUncharacterized protein. (649 aa)
Srsf1.LUncharacterized protein. (298 aa)
Pias4.SUncharacterized protein. (543 aa)
plaaUncharacterized protein. (799 aa)
smc5AAA_15 domain-containing protein. (1063 aa)
Rnf4-aRING-type domain-containing protein. (190 aa)
Pias4.LUncharacterized protein. (544 aa)
A0A310TTQ1Histone H3; Belongs to the histone H3 family. (136 aa)
Clspn.SClaspin. (1286 aa)
plaa-2LOC100158335 protein. (799 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
rnf4LOC495944 protein. (190 aa)
pias3MGC81944 protein. (633 aa)
ufd1Uncharacterized protein. (307 aa)
ufd1-2MGC68571 protein. (307 aa)
top2aDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1579 aa)
sumo2Small ubiquitin-related modifier. (95 aa)
h3f3bHistone H3; Belongs to the histone H3 family. (136 aa)
Sumo1.SUbiquitin-like domain-containing protein. (141 aa)
top1.1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (821 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.