(13 nodes) (2022) Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs. network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	PIK3R1	Phosphoinositide-3-kinase. (722 aa)
	sos1	Uncharacterized protein. (1325 aa)
	cul3	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	sos1-2	Uncharacterized protein. (1325 aa)
	cul3-2	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	map2k1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
	nras	Uncharacterized protein. (189 aa)
	spry2	Uncharacterized protein. (307 aa)
	tbp	LOC503680 protein. (296 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	spry2-2	LOC398313 protein. (314 aa)
	dusp6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (378 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PIK3R1	Ptpn11.S	B7ZRD8	Q92124	Phosphoinositide-3-kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.639
PIK3R1	nras	B7ZRD8	A0A1L8HE10	Phosphoinositide-3-kinase.	Uncharacterized protein.	0.810
PIK3R1	ptpn11b	B7ZRD8	Q6GP31	Phosphoinositide-3-kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.639
PIK3R1	sos1	B7ZRD8	A0A1L8G1Z8	Phosphoinositide-3-kinase.	Uncharacterized protein.	0.560
PIK3R1	sos1-2	B7ZRD8	A0A1L8G7X8	Phosphoinositide-3-kinase.	Uncharacterized protein.	0.560
Ptpn11.S	PIK3R1	Q92124	B7ZRD8	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Phosphoinositide-3-kinase.	0.639
Ptpn11.S	map2k1	Q92124	A0A1L8GSC6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.711
Ptpn11.S	nras	Q92124	A0A1L8HE10	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Uncharacterized protein.	0.671
Ptpn11.S	sos1	Q92124	A0A1L8G1Z8	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Uncharacterized protein.	0.985
Ptpn11.S	sos1-2	Q92124	A0A1L8G7X8	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Uncharacterized protein.	0.985
Ptpn11.S	spry2	Q92124	A0A1L8HHC9	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Uncharacterized protein.	0.563
Ptpn11.S	spry2-2	Q92124	Q90ZT6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	LOC398313 protein.	0.563
cul3	cul3-2	A0A1L8G4G3	A0A1L8GAJ9	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.900
cul3-2	cul3	A0A1L8GAJ9	A0A1L8G4G3	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.900
dusp6	map2k1	Q91663	A0A1L8GSC6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.510
dusp6	spry2	Q91663	A0A1L8HHC9	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein.	0.768
dusp6	spry2-2	Q91663	Q90ZT6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	LOC398313 protein.	0.779
map2k1	Ptpn11.S	A0A1L8GSC6	Q92124	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.711
map2k1	dusp6	A0A1L8GSC6	Q91663	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.510
map2k1	nras	A0A1L8GSC6	A0A1L8HE10	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.764