(70 nodes) (2022) Vangl as a Master Scaffold for WntPlanar Cell Polarity Signaling in Development and Disease. network (Xenopus laevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Arfrp1.S	Uncharacterized protein. (243 aa)
	rab5c	Uncharacterized protein. (215 aa)
	Dact1.S	Uncharacterized protein. (818 aa)
	prickle3-b	Prickle planar cell polarity protein 3-B; Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules. Proteins of the core module include the proteins Frizzled (Fz), Disheveled (Dsh), Van Gogh (Vang), Prickle (Pk), Flamingo (Fmi, Celsr) and Diego (Dgo). The core module proteins develop subcellular asymmetry, accumulating in two groups on opposite sides of epithelial cells. D [...] (536 aa)
	gucy2f	Guanylate cyclase. (1112 aa)
	rack1	WD_REPEATS_REGION domain-containing protein. (276 aa)
	vangl2	Vang-like protein. (521 aa)
	A0A1L8F533	Guanylate cyclase. (1018 aa)
	snx27	Uncharacterized protein. (547 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	Gucy2f.L	Guanylate cyclase. (1052 aa)
	dact1	Uncharacterized protein. (824 aa)
	vangl2-2	Vang-like protein. (521 aa)
	Npr1.L	Guanylate cyclase. (1056 aa)
	A0A1L8FI39	Guanylate cyclase. (1122 aa)
	Arhgap21.S	Uncharacterized protein. (1925 aa)
	Bmi1.S	RING-type domain-containing protein. (367 aa)
	tfap2a	TF_AP-2 domain-containing protein. (470 aa)
	Rab5a.L	Uncharacterized protein. (216 aa)
	cdh2	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (947 aa)
	Fzd6.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
	Scrib.S	Uncharacterized protein. (1826 aa)
	Arhgap21.L	Uncharacterized protein. (1786 aa)
	Bmi1.L	RING-type domain-containing protein. (323 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	rhoa	MGC64296 protein. (193 aa)
	mink1	Misshapen/Nck interacting Kinase. (1270 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	mmp14	Membrane type-1 matrix metalloproteinase 14. (575 aa)
	rac1	MGC114731 protein. (192 aa)
	snx27-2	LOC414692 protein. (547 aa)
	gucy2c	Guanylate cyclase. (1065 aa)
	cdh11-2	Cadherin; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)
	fz3	Fz3 protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
	ift20-2	Intraflagellar transport protein 20. (132 aa)
	A0A310TP95	Guanylate cyclase. (1051 aa)
	A0A1L8HXS4	Guanylate cyclase. (805 aa)
	sec24b-2	Uncharacterized protein. (1098 aa)
	ror2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	sec24b	Uncharacterized protein. (1094 aa)
	A0A1L8HJY9	Guanylate cyclase. (1105 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	kbtbd7-2	BTB domain-containing protein. (645 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	kbtbd7	BTB domain-containing protein. (646 aa)
	ift20	Uncharacterized protein. (132 aa)
	rnf43	RING-type domain-containing protein. (664 aa)
	gucy2d	Guanylate cyclase. (1078 aa)
	Prickle1.L	Uncharacterized protein. (832 aa)
	prickle1	Uncharacterized protein. (835 aa)
	prickle2-2	Uncharacterized protein. (833 aa)
	Prkcd.S	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (806 aa)
	Jun.L	BZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
	A0A1L8GLK4	Guanylate cyclase. (693 aa)
	prickle2	Uncharacterized protein. (833 aa)
	A0A1L8GGS3	Guanylate cyclase. (1065 aa)
	Mmp2.S	Uncharacterized protein. (656 aa)
	ryk	Uncharacterized protein. (596 aa)
	cul3-2	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	ankrd6-2	ANK_REP_REGION domain-containing protein. (776 aa)
	fzd3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
	cul3	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	ankrd6	ANK_REP_REGION domain-containing protein. (776 aa)
	fzd6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (724 aa)
	c-Jun	C-Jun protein; Belongs to the bZIP family. (312 aa)
	csnk1e	Casein kinase I epsilon; Belongs to the protein kinase superfamily. (416 aa)
	nup62	Nuclear pore complex glycoprotein p62. (547 aa)
	rack1-2	Gnb2l1-prov protein. (317 aa)
	ror2-2	Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	Tfap2a.L	TF_AP-2 domain-containing protein. (472 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Arfrp1.S	vangl2	A0A1L8ELY5	A0A1L8F4R0	Uncharacterized protein.	Vang-like protein.	0.447
Arfrp1.S	vangl2-2	A0A1L8ELY5	A0A1L8FCL1	Uncharacterized protein.	Vang-like protein.	0.447
Arhgap21.L	prickle1	A0A1L8FVK0	A0A1L8GUA2	Uncharacterized protein.	Uncharacterized protein.	0.532
Arhgap21.L	prickle3-b	A0A1L8FVK0	A0A1L8F1M4	Uncharacterized protein.	Prickle planar cell polarity protein 3-B; Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules. Proteins of the core module include the proteins Frizzled (Fz), Disheveled (Dsh), Van Gogh (Vang), Prickle (Pk), Flamingo (Fmi, Celsr) and Diego (Dgo). The core module proteins develop subcellular asymmetry, accumulating in two groups on opposite sides of epithelial cells. D [...]	0.446
Arhgap21.L	rac1	A0A1L8FVK0	Q58E25	Uncharacterized protein.	MGC114731 protein.	0.502
Arhgap21.L	rhoa	A0A1L8FVK0	Q7SZA9	Uncharacterized protein.	MGC64296 protein.	0.611
Arhgap21.S	prickle1	A0A1L8FQS3	A0A1L8GUA2	Uncharacterized protein.	Uncharacterized protein.	0.534
Arhgap21.S	prickle3-b	A0A1L8FQS3	A0A1L8F1M4	Uncharacterized protein.	Prickle planar cell polarity protein 3-B; Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules. Proteins of the core module include the proteins Frizzled (Fz), Disheveled (Dsh), Van Gogh (Vang), Prickle (Pk), Flamingo (Fmi, Celsr) and Diego (Dgo). The core module proteins develop subcellular asymmetry, accumulating in two groups on opposite sides of epithelial cells. D [...]	0.449
Arhgap21.S	rac1	A0A1L8FQS3	Q58E25	Uncharacterized protein.	MGC114731 protein.	0.503
Arhgap21.S	rhoa	A0A1L8FQS3	Q7SZA9	Uncharacterized protein.	MGC64296 protein.	0.612
Bmi1.L	ctnnb1	A0A1L8FVK1	Q63ZT4	RING-type domain-containing protein.	Beta-catenin protein.	0.409
Bmi1.S	ctnnb1	A0A1L8FQV8	Q63ZT4	RING-type domain-containing protein.	Beta-catenin protein.	0.409
Dact1.S	csnk1e	A0A1L8EZZ3	Q9PUI2	Uncharacterized protein.	Casein kinase I epsilon; Belongs to the protein kinase superfamily.	0.606
Dact1.S	ctnnb1	A0A1L8EZZ3	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.615
Dact1.S	prickle1	A0A1L8EZZ3	A0A1L8GUA2	Uncharacterized protein.	Uncharacterized protein.	0.551
Dact1.S	prickle2	A0A1L8EZZ3	A0A1L8GI20	Uncharacterized protein.	Uncharacterized protein.	0.410
Dact1.S	prickle2-2	A0A1L8EZZ3	A0A1L8GQ36	Uncharacterized protein.	Uncharacterized protein.	0.410
Dact1.S	vangl2	A0A1L8EZZ3	A0A1L8F4R0	Uncharacterized protein.	Vang-like protein.	0.788
Dact1.S	vangl2-2	A0A1L8EZZ3	A0A1L8FCL1	Uncharacterized protein.	Vang-like protein.	0.788
Fzd4.S	Fzd6.S	A0A1L8HB90	A0A1L8FTP5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.586