57 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	vsx2	Uncharacterized protein. (325 aa)
	neurod1	Neurogenic differentiation factor. (352 aa)
	otx2	Homeobox domain-containing protein. (288 aa)
	Crx.L	Homeobox domain-containing protein. (290 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	crx	Homeobox domain-containing protein. (290 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	ttll5	Uncharacterized protein. (1129 aa)
	otx2-2	Homeobox domain-containing protein. (289 aa)
	Vax1.S	Homeobox domain-containing protein. (295 aa)
	Vax1.L	Homeobox domain-containing protein. (287 aa)
	Egr2.L	Uncharacterized protein. (418 aa)
	Cdhr1.L	Uncharacterized protein. (872 aa)
	ttll10	Uncharacterized protein. (709 aa)
	A0A1L8FND1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	vsx1	Uncharacterized protein. (340 aa)
	Esr1.S	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	prdm1	Uncharacterized protein. (780 aa)
	prdm1-2	Uncharacterized protein. (780 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	maf	BZIP domain-containing protein; Belongs to the bZIP family. (344 aa)
	ttll7	Uncharacterized protein. (910 aa)
	A0A1L8GHL0	Rhodopsin. (354 aa)
	rom1	Uncharacterized protein. (345 aa)
	maf-2	BZIP domain-containing protein; Belongs to the bZIP family. (351 aa)
	Abca4.L	Uncharacterized protein. (1776 aa)
	Rho.L	Rhodopsin. (459 aa)
	Opsin	Rhodopsin. (403 aa)
	nr2e3	Uncharacterized protein. (404 aa)
	Wwc1.S	Uncharacterized protein. (1610 aa)
	egr1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (497 aa)
	gucy2d	Guanylate cyclase. (1078 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	znf385a	Uncharacterized protein. (403 aa)
	znf385a-2	Uncharacterized protein. (406 aa)
	vax2	Homeobox domain-containing protein. (294 aa)
	wwc2	Uncharacterized protein. (1171 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	wwc2-2	Uncharacterized protein. (1152 aa)
	fgf2-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ins-2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	vax2-2	Vax2 protein. (302 aa)
	l-maf-A	BZIP transcription factor L-Maf. (267 aa)
	rax2	Retina and anterior neural fold homeobox 2b. (228 aa)
	cdh11-2	Cadherin; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)
	rax2-2	Retinal homeobox-like transcription factor. (228 aa)
	guca1a	MGC84396 protein. (203 aa)
	guca1a-2	MGC84227 protein. (202 aa)
	guca1al	MGC84170 protein. (188 aa)
	neurod1-2	Neurogenic differentiation factor. (357 aa)
	ttll7-2	MGC80161 protein. (910 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	prph2	MGC64379 protein. (350 aa)
	six6	Six6-A protein. (244 aa)
	prph-2	Peripherin-2. (346 aa)
	six6-2	Homeobox protein Optx2. (244 aa)
	mecp2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (467 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FND1	A0A1L8GHL0	A0A1L8FND1	A0A1L8GHL0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Rhodopsin.	0.485
A0A1L8FND1	Esr1.S	A0A1L8FND1	A0A1L8G265	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.724
A0A1L8FND1	Opsin	A0A1L8FND1	A0A1L8GPM0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Rhodopsin.	0.488
A0A1L8FND1	Rho.L	A0A1L8FND1	A0A1L8GPJ9	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Rhodopsin.	0.547
A0A1L8FND1	Tp53.L	A0A1L8FND1	A0A1L8H4M6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	P53 domain-containing protein.	0.703
A0A1L8FND1	esr1	A0A1L8FND1	Q6W5G7	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.724
A0A1L8FND1	fgf2	A0A1L8FND1	A0A1L8HLX5	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.784
A0A1L8FND1	fgf2-2	A0A1L8FND1	B7ZPK6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.656
A0A1L8FND1	ins	A0A1L8FND1	A0A1L8GD41	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.907
A0A1L8FND1	ins-2	A0A1L8FND1	B7ZQP1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.905
A0A1L8FND1	maf	A0A1L8FND1	A0A1L8GEH4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	BZIP domain-containing protein; Belongs to the bZIP family.	0.418
A0A1L8FND1	maf-2	A0A1L8FND1	A0A1L8GKN9	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	BZIP domain-containing protein; Belongs to the bZIP family.	0.418
A0A1L8FND1	neurod1	A0A1L8FND1	A0A1L8EWE3	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Neurogenic differentiation factor.	0.642
A0A1L8FND1	neurod1-2	A0A1L8FND1	Q6GPW1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Neurogenic differentiation factor.	0.642
A0A1L8FND1	tgfb1	A0A1L8FND1	A0A1L8F3Y7	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.683
A0A1L8FND1	tgfb1-2	A0A1L8FND1	A0A1L8F936	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.683
A0A1L8GHL0	A0A1L8FND1	A0A1L8GHL0	A0A1L8FND1	Rhodopsin.	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.485
A0A1L8GHL0	Abca4.L	A0A1L8GHL0	A0A1L8GMV0	Rhodopsin.	Uncharacterized protein.	0.632
A0A1L8GHL0	Crx.L	A0A1L8GHL0	A0A1L8F3X7	Rhodopsin.	Homeobox domain-containing protein.	0.808
A0A1L8GHL0	Opsin	A0A1L8GHL0	A0A1L8GPM0	Rhodopsin.	Rhodopsin.	0.900