(35 nodes) (2022) The Less Well-Known Little Brothers: The SLC9BNHA Sodium Proton Exchanger Subfamily-Structure, Function, Regulation and Potential Drug-Target Approaches. network (Xenopus laevis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	Tnfsf11.L	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (290 aa)
	Nfatc2.S	RHD domain-containing protein. (884 aa)
	wnk4	Protein kinase domain-containing protein. (1573 aa)
	A0A1L8ENI2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1194 aa)
	nfatc2	RHD domain-containing protein. (896 aa)
	wnk4-2	Protein kinase domain-containing protein. (1575 aa)
	A0A1L8EUA6	Uncharacterized protein. (3827 aa)
	A0A1L8EVB6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1194 aa)
	pkd1	Uncharacterized protein. (4353 aa)
	adcy8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa)
	adcy1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1116 aa)
	A0A1L8G048	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa)
	tfrc	Uncharacterized protein. (775 aa)
	adipoq	C1q domain-containing protein. (233 aa)
	A0A1L8G5C7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	osr1	Uncharacterized protein. (259 aa)
	tfrc-2	Uncharacterized protein. (775 aa)
	osr1-2	Uncharacterized protein. (259 aa)
	adcy3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	nfatc3	RHD domain-containing protein. (885 aa)
	Cpa1.L	Uncharacterized protein. (424 aa)
	lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	tnfsf11	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (290 aa)
	slc9b2	Na_H_Exchanger domain-containing protein. (540 aa)
	A0A1L8HPT0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1025 aa)
	Slc9b2.L	Na_H_Exchanger domain-containing protein. (540 aa)
	pkd2	EF-hand domain-containing protein. (947 aa)
	adcy4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
	oxsr1	Stk39 protein. (528 aa)
	nf-at	Nuclear factor of activated T-cell. (884 aa)
	ins-2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	lep-2	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	adipoq-2	MGC84292 protein. (235 aa)
	cpa1	MGC64526 protein. (416 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENI2	A0A1L8G048	A0A1L8ENI2	A0A1L8G048	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.462
A0A1L8ENI2	A0A1L8G5C7	A0A1L8ENI2	A0A1L8G5C7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.424
A0A1L8ENI2	A0A1L8HPT0	A0A1L8ENI2	A0A1L8HPT0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.569
A0A1L8ENI2	adcy1	A0A1L8ENI2	A0A1L8FWP0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.461
A0A1L8ENI2	adcy3	A0A1L8ENI2	A0A1L8GC45	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.424
A0A1L8ENI2	adcy4	A0A1L8ENI2	A0A1L8HZJ5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.568
A0A1L8ENI2	adcy8	A0A1L8ENI2	A0A1L8FTY2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.462
A0A1L8ENI2	ins	A0A1L8ENI2	A0A1L8GD41	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.420
A0A1L8ENI2	ins-2	A0A1L8ENI2	B7ZQP1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.420
A0A1L8EUA6	pkd2	A0A1L8EUA6	A0A1L8HVJ9	Uncharacterized protein.	EF-hand domain-containing protein.	0.999
A0A1L8EVB6	A0A1L8G048	A0A1L8EVB6	A0A1L8G048	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.462
A0A1L8EVB6	A0A1L8G5C7	A0A1L8EVB6	A0A1L8G5C7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.424
A0A1L8EVB6	A0A1L8HPT0	A0A1L8EVB6	A0A1L8HPT0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.568
A0A1L8EVB6	adcy1	A0A1L8EVB6	A0A1L8FWP0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.460
A0A1L8EVB6	adcy3	A0A1L8EVB6	A0A1L8GC45	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.423
A0A1L8EVB6	adcy4	A0A1L8EVB6	A0A1L8HZJ5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.567
A0A1L8EVB6	adcy8	A0A1L8EVB6	A0A1L8FTY2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.462
A0A1L8EVB6	ins	A0A1L8EVB6	A0A1L8GD41	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.420
A0A1L8EVB6	ins-2	A0A1L8EVB6	B7ZQP1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.420
A0A1L8G048	A0A1L8ENI2	A0A1L8G048	A0A1L8ENI2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.462