(22 nodes) (2022) Rad53 arrests leading and lagging strand DNA synthesis via distinct mechanisms in response to DNA replication stress. network (Xenopus laevis)

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Predicted Interactions

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Your Input:
	mcm6.2	DNA helicase; Belongs to the MCM family. (825 aa)
	Dbf4b.L	DBF4-type domain-containing protein. (784 aa)
	Dna2.S	Uncharacterized protein. (1053 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	Pold1.L	DNA polymerase. (1109 aa)
	dbf4	Uncharacterized protein. (661 aa)
	mcm6	DNA helicase; Belongs to the MCM family. (821 aa)
	fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa)
	mcm2	DNA helicase; Belongs to the MCM family. (885 aa)
	fen1-2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa)
	Mcm2.L	DNA helicase; Belongs to the MCM family. (886 aa)
	A0A1L8GS29	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (268 aa)
	Mrc1.L	C-type lectin domain-containing protein. (220 aa)
	Rfc2.L	AAA domain-containing protein. (359 aa)
	rfc1	Replication factor C subunit 1. (1147 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	cdc45	Uncharacterized protein. (567 aa)
	Clspn.S	Claspin. (1286 aa)
	rfc4	Replication factor C p37 subunit. (363 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8GS29	Chek2.L	A0A1L8GS29	A0A1L8I0A0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.491
A0A1L8GS29	Dna2.S	A0A1L8GS29	A0A1L8FF41	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.794
A0A1L8GS29	Mcm2.L	A0A1L8GS29	A0A1L8GPN4	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA helicase; Belongs to the MCM family.	0.864
A0A1L8GS29	Pold1.L	A0A1L8GS29	A0A1L8FNR6	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA polymerase.	0.995
A0A1L8GS29	Rfc2.L	A0A1L8GS29	A0A1L8HGA4	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	AAA domain-containing protein.	0.996
A0A1L8GS29	cdc45	A0A1L8GS29	A0A1L8I0M4	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.510
A0A1L8GS29	chek1	A0A1L8GS29	A0A1L8FFS1	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.635
A0A1L8GS29	chek1-2	A0A1L8GS29	A0A1L8FL95	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Protein kinase domain-containing protein.	0.635
A0A1L8GS29	fen1	A0A1L8GS29	A0A1L8GDJ8	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.986
A0A1L8GS29	fen1-2	A0A1L8GS29	A0A1L8GJ67	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.986
A0A1L8GS29	mcm2	A0A1L8GS29	A0A1L8GHP1	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA helicase; Belongs to the MCM family.	0.864
A0A1L8GS29	mcm6	A0A1L8GS29	A0A1L8FWS1	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA helicase; Belongs to the MCM family.	0.744
A0A1L8GS29	mcm6.2	A0A1L8GS29	A0A090B468	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA helicase; Belongs to the MCM family.	0.744
A0A1L8GS29	rfc1	A0A1L8GS29	A0A1L8HTJ6	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Replication factor C subunit 1.	0.994
A0A1L8GS29	rfc4	A0A1L8GS29	Q76LD2	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Replication factor C p37 subunit.	0.999
Chek2.L	A0A1L8GS29	A0A1L8I0A0	A0A1L8GS29	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.491
Chek2.L	Clspn.S	A0A1L8I0A0	F8WKR8	Uncharacterized protein.	Claspin.	0.891
Chek2.L	Dbf4b.L	A0A1L8I0A0	A0A1L8ESD2	Uncharacterized protein.	DBF4-type domain-containing protein.	0.971
Chek2.L	Dna2.S	A0A1L8I0A0	A0A1L8FF41	Uncharacterized protein.	Uncharacterized protein.	0.910
Chek2.L	Mcm2.L	A0A1L8I0A0	A0A1L8GPN4	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.779