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| | Tdp2.S | Endo/exonuclease/phosphatase domain-containing protein. (382 aa) |
| | mcm6.2 | DNA helicase; Belongs to the MCM family. (825 aa) |
| | sumo2 | Small ubiquitin-related modifier. (95 aa) |
| | h3f3b | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | A0A1L8ENU1 | Uncharacterized protein; Belongs to the histone H2B family. (98 aa) |
| | Sumo1.S | Ubiquitin-like domain-containing protein. (141 aa) |
| | usp7 | Uncharacterized protein; Belongs to the peptidase C19 family. (1123 aa) |
| | rtel1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1275 aa) |
| | top1.1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (821 aa) |
| | Sumo1.L | Ubiquitin-like domain-containing protein. (148 aa) |
| | usp7-2 | Usp7; Belongs to the peptidase C19 family. (1124 aa) |
| | A0A1L8EY07 | Histone H3; Belongs to the histone H3 family. (120 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1022 aa) |
| | Endog.L | Endonuclease. (290 aa) |
| | Alkbh1.L | Fe2OG dioxygenase domain-containing protein. (397 aa) |
| | Tdp1.L | Uncharacterized protein. (597 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa) |
| | cdk1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa) |
| | chek1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa) |
| | Cdk1.L | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (333 aa) |
| | chek1-2 | Protein kinase domain-containing protein. (510 aa) |
| | A0A1L8FQ56 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | Cdc25a.S | Rhodanese domain-containing protein. (172 aa) |
| | A0A1L8FQA5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | Vim.S | IF rod domain-containing protein; Belongs to the intermediate filament family. (463 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (858 aa) |
| | vcpip1 | OTU domain-containing protein. (1186 aa) |
| | Vim.L | IF rod domain-containing protein; Belongs to the intermediate filament family. (458 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | Mcm4.S | DNA helicase; Belongs to the MCM family. (863 aa) |
| | vcpip1-2 | OTU domain-containing protein. (1191 aa) |
| | hist2h3c | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | H2B-2 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (233 aa) |
| | sprtn | Uncharacterized protein. (565 aa) |
| | Znf451.L | Uncharacterized protein. (1207 aa) |
| | A0A1L8G6R5 | Histone H2B; Belongs to the histone H2B family. (347 aa) |
| | A0A1L8G6S1 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (238 aa) |
| | A0A1L8G795 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | hltf | Uncharacterized protein. (1000 aa) |
| | top1.2 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (770 aa) |
| | ccs | HMA domain-containing protein. (274 aa) |
| | Hmces.L | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (365 aa) |
| | Cdc25c1 | Rhodanese domain-containing protein. (550 aa) |
| | rad50 | Zinc-hook domain-containing protein. (1311 aa) |
| | rad50-2 | Zinc-hook domain-containing protein. (1312 aa) |
| | Dnmt1.L | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1488 aa) |
| | rev1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1230 aa) |
| | rev1-2 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1237 aa) |
| | Vcp.S | Uncharacterized protein; Belongs to the AAA ATPase family. (805 aa) |
| | Rnf4-a | RING-type domain-containing protein. (190 aa) |
| | Pias4.L | Uncharacterized protein. (544 aa) |
| | Chek2.L | Uncharacterized protein. (392 aa) |
| | Top3b.L | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (824 aa) |
| | cdc45 | Uncharacterized protein. (567 aa) |
| | A0A310TM08 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | A0A310TTQ1 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | A0A310U368 | Histone H2B; Belongs to the histone H2B family. (94 aa) |
| | parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa) |
| | rnf4 | LOC495944 protein. (190 aa) |
| | top2a | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1579 aa) |
| | H2B | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
