(38 nodes) (2022) Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope. network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Esr1.S	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	lef1-2	Lymphoid enhancer factor XLEF-1. (372 aa)
	snca	Alpha-synuclein; Belongs to the synuclein family. (141 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	hif1a	Hif1a-prov protein. (802 aa)
	tbxt-2	MGC81453 protein. (432 aa)
	MGC80089	Beta-synuclein; Belongs to the synuclein family. (133 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	sncb	Beta-synuclein; Belongs to the synuclein family. (134 aa)
	src	Tyrosine-protein kinase. (532 aa)
	metap2	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (481 aa)
	lin28a	RNA-binding protein LIN-28A. (195 aa)
	LOC496290	LOC496290 protein. (461 aa)
	e2f1-2	LOC100036852 protein. (426 aa)
	gne	Epimerase_2 domain-containing protein. (796 aa)
	A0A1L8HMD5	Alpha-synuclein; Belongs to the synuclein family. (212 aa)
	lef1	HMG box domain-containing protein. (372 aa)
	erbb3-2	Protein kinase domain-containing protein. (1347 aa)
	erbb3	Protein kinase domain-containing protein. (1331 aa)
	rnf43	RING-type domain-containing protein. (664 aa)
	brd4-2	Uncharacterized protein. (1366 aa)
	frs2	IRS-type PTB domain-containing protein. (518 aa)
	METAP2	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (483 aa)
	skp1-2	Uncharacterized protein; Belongs to the SKP1 family. (221 aa)
	Frs2.S	IRS-type PTB domain-containing protein. (509 aa)
	brd4	Uncharacterized protein. (1351 aa)
	skp1	Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
	crbn-2	Uncharacterized protein. (447 aa)
	crbn	Uncharacterized protein. (447 aa)
	cul3-2	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	cul3	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	lin28b	CCHC-type domain-containing protein. (253 aa)
	tbxt	Uncharacterized protein. (432 aa)
	akt2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (486 aa)
	Fkbp1a.L	Peptidylprolyl isomerase. (111 aa)
	Tm7	Uncharacterized protein; Belongs to the tropomyosin family. (284 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	e2f1	E2F_TDP domain-containing protein. (427 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8HMD5	LOC496290	A0A1L8HMD5	A1L2I1	Alpha-synuclein; Belongs to the synuclein family.	LOC496290 protein.	0.518
A0A1L8HMD5	MGC80089	A0A1L8HMD5	Q6GQG2	Alpha-synuclein; Belongs to the synuclein family.	Beta-synuclein; Belongs to the synuclein family.	0.453
A0A1L8HMD5	sncb	A0A1L8HMD5	Q5U4S4	Alpha-synuclein; Belongs to the synuclein family.	Beta-synuclein; Belongs to the synuclein family.	0.453
Axin1.S	ctnnb1	A0A1L8ER48	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.999
Axin1.S	cul3	A0A1L8ER48	A0A1L8G4G3	Uncharacterized protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.542
Axin1.S	cul3-2	A0A1L8ER48	A0A1L8GAJ9	Uncharacterized protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.542
Axin1.S	lef1	A0A1L8ER48	A0A1L8HM07	Uncharacterized protein.	HMG box domain-containing protein.	0.918
Axin1.S	lef1-2	A0A1L8ER48	Q90ZB8	Uncharacterized protein.	Lymphoid enhancer factor XLEF-1.	0.920
Axin1.S	rnf43	A0A1L8ER48	A0A1L8H5W0	Uncharacterized protein.	RING-type domain-containing protein.	0.731
Axin1.S	skp1	A0A1L8ER48	A0A1L8GR29	Uncharacterized protein.	Uncharacterized protein; Belongs to the SKP1 family.	0.819
Axin1.S	skp1-2	A0A1L8ER48	A0A1L8GWN2	Uncharacterized protein.	Uncharacterized protein; Belongs to the SKP1 family.	0.819
Axin1.S	src	A0A1L8ER48	Q2TAR1	Uncharacterized protein.	Tyrosine-protein kinase.	0.576
Axin1.S	tbxt	A0A1L8ER48	A0A1L8G2B1	Uncharacterized protein.	Uncharacterized protein.	0.447
Axin1.S	tbxt-2	A0A1L8ER48	Q6INQ0	Uncharacterized protein.	MGC81453 protein.	0.446
Esr1.S	METAP2	A0A1L8G265	A0A1L8GYF2	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.	0.602
Esr1.S	brd4	A0A1L8G265	A0A1L8GRJ4	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein.	0.471
Esr1.S	brd4-2	A0A1L8G265	A0A1L8H2F1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein.	0.470
Esr1.S	ctnnb1	A0A1L8G265	Q63ZT4	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Beta-catenin protein.	0.759
Esr1.S	e2f1	A0A1L8G265	A0A1L8EMM8	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	E2F_TDP domain-containing protein.	0.513
Esr1.S	e2f1-2	A0A1L8G265	A1L2H8	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	LOC100036852 protein.	0.513