STRINGSTRING
hpgd hpgd Nodal.L Nodal.L sorl1 sorl1 ybx1 ybx1 Sox17a.S Sox17a.S sox17b.1 sox17b.1 AGO2 AGO2 Bmper.L Bmper.L sox17b.1-2 sox17b.1-2 AGO2-2 AGO2-2 tgfb2 tgfb2 tbxt tbxt Chrd.1.S Chrd.1.S xrn1 xrn1 tgfb2-2 tgfb2-2 Foxa2.L Foxa2.L xrn1-2 xrn1-2 pax6 pax6 cnot1 cnot1 pax6-2 pax6-2 Lsm14a.L Lsm14a.L cnot1-2 cnot1-2 ro60 ro60 A0A1L8GRI1 A0A1L8GRI1 Xnr2 Xnr2 Smad3 Smad3 rbpms2 rbpms2 edc3 edc3 dpysl2 dpysl2 nodal5 nodal5 Xnr5-6 Xnr5-6 A0A1L8H2D1 A0A1L8H2D1 A0A1L8H2D6 A0A1L8H2D6 Nodal3.2.L Nodal3.2.L nodal1 nodal1 A0A1L8H2G3 A0A1L8H2G3 lgals9 lgals9 dhh dhh Eif4e1b.S Eif4e1b.S fgf5 fgf5 Cer1.S Cer1.S A0A1L8HPW4 A0A1L8HPW4 eif4enif1 eif4enif1 fgf5-2 fgf5-2 Klf4 Klf4 lif lif eif4enif1-2 eif4enif1-2 Ddx6.S Ddx6.S LOC398065 LOC398065 lhx1 lhx1 nodal2 nodal2 bmp4 bmp4 grem1 grem1 crim1 crim1 nodal6 nodal6 Xnr5-3 Xnr5-3 eif4e eif4e rbpms2-2 rbpms2-2 tob2 tob2 Inhbb Inhbb hpgd-2 hpgd-2 tbxt-2 tbxt-2 klf17 klf17 Gapdh.S Gapdh.S gapdh gapdh tob2-2 tob2-2 smad3 smad3 bmp4-2 bmp4-2 nodal6-2 nodal6-2 nodal5.2 nodal5.2 Sox2.S Sox2.S inhbb inhbb asic4 asic4 Acvr1.L Acvr1.L otx2 otx2 Zic3.S Zic3.S tgfb1 tgfb1 nudt16 nudt16 Endog.L Endog.L Zic3 Zic3 tgfb1-2 tgfb1-2 otx2-2 otx2-2 rad51 rad51 prkg1 prkg1 nodal nodal
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hpgdUncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (264 aa)
Nodal.LTGF_BETA_2 domain-containing protein. (402 aa)
sorl1Uncharacterized protein. (2199 aa)
ybx1CSD_1 domain-containing protein. (303 aa)
Sox17a.SUncharacterized protein. (377 aa)
sox17b.1Uncharacterized protein. (373 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (855 aa)
Bmper.LUncharacterized protein. (687 aa)
sox17b.1-2Uncharacterized protein. (373 aa)
AGO2-2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (818 aa)
tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
tbxtUncharacterized protein. (432 aa)
Chrd.1.SChordin; Belongs to the chordin family. (941 aa)
xrn1Uncharacterized protein. (1727 aa)
tgfb2-2Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
Foxa2.LFork-head domain-containing protein. (434 aa)
xrn1-25'-3' exoribonuclease 1. (1700 aa)
pax6Uncharacterized protein. (467 aa)
cnot1Uncharacterized protein. (2387 aa)
pax6-2Uncharacterized protein. (467 aa)
Lsm14a.LUncharacterized protein. (472 aa)
cnot1-2Uncharacterized protein. (2405 aa)
ro60TROVE domain-containing protein. (538 aa)
A0A1L8GRI1TGF_BETA_2 domain-containing protein. (406 aa)
Xnr2TGF_BETA_2 domain-containing protein. (405 aa)
Smad3Mothers against decapentaplegic homolog. (425 aa)
rbpms2RRM domain-containing protein. (196 aa)
edc3Uncharacterized protein. (500 aa)
dpysl2Amidohydro-rel domain-containing protein. (657 aa)
nodal5TGF_BETA_2 domain-containing protein. (384 aa)
Xnr5-6TGF_BETA_2 domain-containing protein. (386 aa)
A0A1L8H2D1TGF_BETA_2 domain-containing protein. (401 aa)
A0A1L8H2D6TGF_BETA_2 domain-containing protein. (348 aa)
Nodal3.2.LTGF_BETA_2 domain-containing protein. (401 aa)
nodal1TGF_BETA_2 domain-containing protein. (406 aa)
A0A1L8H2G3TGF_BETA_2 domain-containing protein. (401 aa)
lgals9Galectin. (446 aa)
dhhHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (398 aa)
Eif4e1b.SUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (280 aa)
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
Cer1.SCTCK domain-containing protein. (338 aa)
A0A1L8HPW4Uncharacterized protein. (216 aa)
eif4enif1Uncharacterized protein. (953 aa)
fgf5-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
Klf4Uncharacterized protein. (454 aa)
lifUncharacterized protein. (216 aa)
eif4enif1-2Uncharacterized protein. (956 aa)
Ddx6.SUncharacterized protein; Belongs to the DEAD box helicase family. (481 aa)
LOC398065LOC398065 protein. (666 aa)
lhx1Homeobox protein. (403 aa)
nodal2Xnr-2. (405 aa)
bmp4Bone morphogenetic protein 4. (401 aa)
grem1Gremlin. (182 aa)
crim1Cysteine-rich motor neuron 1. (1029 aa)
nodal6Xnr6b protein. (379 aa)
Xnr5-3Xnr5-3. (386 aa)
eif4eMGC85107 protein; Belongs to the eukaryotic initiation factor 4E family. (213 aa)
rbpms2-2MGC84222 protein. (197 aa)
tob2MGC85389 protein. (298 aa)
InhbbInhbb protein. (370 aa)
hpgd-2Hpgd-prov protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (264 aa)
tbxt-2MGC81453 protein. (432 aa)
klf17Biklf-A protein. (413 aa)
Gapdh.SGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
tob2-2TOB2 protein. (298 aa)
smad3Mothers against decapentaplegic homolog. (425 aa)
bmp4-2Bone morphogenetic protein 4. (400 aa)
nodal6-2Xnr6. (378 aa)
nodal5.2Xnr5-10. (384 aa)
Sox2.SHMG box domain-containing protein. (194 aa)
inhbbTGF_BETA_2 domain-containing protein. (370 aa)
asic4Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (535 aa)
Acvr1.LReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (624 aa)
otx2Homeobox domain-containing protein. (288 aa)
Zic3.SUncharacterized protein. (441 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
nudt16Nudix hydrolase domain-containing protein. (212 aa)
Endog.LEndonuclease. (290 aa)
Zic3Uncharacterized protein. (441 aa)
tgfb1-2Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
otx2-2Homeobox domain-containing protein. (289 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
prkg1cGMP-dependent protein kinase. (673 aa)
nodalTGF_BETA_2 domain-containing protein. (402 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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